Reversal of stress fibre formation by Nitric Oxide mediated RhoA inhibition leads to reduction in the height of preformed thrombi
Abstract Evidence has emerged to suggest that thrombi are dynamic structures with distinct areas of differing platelet activation and inhibition. We hypothesised that Nitric oxide (NO), a platelet inhibitor, can modulate the actin cytoskeleton reversing platelet spreading, and therefore reduce the c...
Guardado en:
Autores principales: | L. Atkinson, M. Z. Yusuf, A. Aburima, Y. Ahmed, S. G. Thomas, K. M. Naseem, S. D. J. Calaminus |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2018
|
Materias: | |
Acceso en línea: | https://doaj.org/article/47b80d4fc1b24e3cb0f8f547d9aabf66 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Prostacyclin reverses platelet stress fibre formation causing platelet aggregate instability
por: M. Z. Yusuf, et al.
Publicado: (2017) -
Optogenetic control of RhoA reveals zyxin-mediated elasticity of stress fibres
por: Patrick W. Oakes, et al.
Publicado: (2017) -
Histamine-induced biphasic activation of RhoA allows for persistent RhoA signaling.
por: Jason Z Zhang, et al.
Publicado: (2020) -
The P2Y12 Receptor Antagonist Selatogrel Dissolves Preformed Platelet Thrombi In Vivo
por: Lydie Crescence, et al.
Publicado: (2021) -
RhoA phosphorylation mediated by Rho/RhoA-associated kinase pathway improves the anti-freezing potentiality of murine hatched and diapaused blastocysts
por: Meichao Gu, et al.
Publicado: (2017)