Downhill hiking improves low-grade inflammation, triglycerides, body weight and glucose tolerance

Abstract Exercise is a well-established tool for cardiovascular risk reduction. Particularly eccentric exercise, which essentially means walking downwards could favour more people becoming physically active. With the present controlled study, we tested the hypothesis that eccentric exercise can impr...

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Autores principales:	Heinz Drexel, Arthur Mader, Christoph H. Saely, Gerda Tautermann, Jörn F. Dopheide, Alexander Vonbank
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/47b8753caab64ff99517d76123a1c43a
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spelling	oai:doaj.org-article:47b8753caab64ff99517d76123a1c43a2021-12-02T16:14:09ZDownhill hiking improves low-grade inflammation, triglycerides, body weight and glucose tolerance10.1038/s41598-021-93879-12045-2322https://doaj.org/article/47b8753caab64ff99517d76123a1c43a2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93879-1https://doaj.org/toc/2045-2322Abstract Exercise is a well-established tool for cardiovascular risk reduction. Particularly eccentric exercise, which essentially means walking downwards could favour more people becoming physically active. With the present controlled study, we tested the hypothesis that eccentric exercise can improve insulin sensitivity, triglyceride handling, body mass index, glucose tolerance and inflammation. We allocated 127 healthy sedentary individuals to one of two groups: (i) an active group of 102 individuals walking downwards a predefined route three to five times per week over two months, covering a difference in altitude of 540 m; for the upward route a cable car was used, for which adherence was recorded electronically and (ii) a matched control group of 25 individuals who stayed sedentary. Fasting and postprandial metabolic profiles were obtained at baseline and after two months. Compared to baseline, eccentric exercise significantly improved HOMA insulin resistance (1.94 ± 1.65 vs. 1.71 ± 1.36 (µU−1 ml) × ((mmol/l)−122.5); p = 0.038) and resulted in a decrease in fasting glucose (97 ± 15 vs. 94 ± 9 mg dl−1; p = 0.025) and glucose tolerance (238 ± 50 vs. 217 ± 47 mg dl−1 h−1; p < 0.001), whereas these parameters did not change significantly in the control group. Eccentric exercise significantly improved triglyceride tolerance (1923 ± 1295 vs. 1670 ± 1085 mg dl−1 h−1; p = 0.003), whereas triglyceride tolerance remained unchanged in the control group (p = 0.819). Furthermore, body mass index (27.7 ± 4.3 vs. 27.4 ± 4.3 kg m−2; p = 0.003) and C-reactive protein (0.27 ± 0.42 vs. 0.23 ± 0.25 mg dl−1; p = 0.031) were significantly lowered in the eccentric exercise group but not in the control group. Downhill walking, a type of exercise is a promising unusual exercise modality with favorable effects on body mass index, insulin action, on postprandial glucose and triglyceride handling and on C-reactive protein. ClinicalTrials.gov Identifier: NCT00386854.Heinz DrexelArthur MaderChristoph H. SaelyGerda TautermannJörn F. DopheideAlexander VonbankNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Heinz Drexel Arthur Mader Christoph H. Saely Gerda Tautermann Jörn F. Dopheide Alexander Vonbank Downhill hiking improves low-grade inflammation, triglycerides, body weight and glucose tolerance
description	Abstract Exercise is a well-established tool for cardiovascular risk reduction. Particularly eccentric exercise, which essentially means walking downwards could favour more people becoming physically active. With the present controlled study, we tested the hypothesis that eccentric exercise can improve insulin sensitivity, triglyceride handling, body mass index, glucose tolerance and inflammation. We allocated 127 healthy sedentary individuals to one of two groups: (i) an active group of 102 individuals walking downwards a predefined route three to five times per week over two months, covering a difference in altitude of 540 m; for the upward route a cable car was used, for which adherence was recorded electronically and (ii) a matched control group of 25 individuals who stayed sedentary. Fasting and postprandial metabolic profiles were obtained at baseline and after two months. Compared to baseline, eccentric exercise significantly improved HOMA insulin resistance (1.94 ± 1.65 vs. 1.71 ± 1.36 (µU−1 ml) × ((mmol/l)−122.5); p = 0.038) and resulted in a decrease in fasting glucose (97 ± 15 vs. 94 ± 9 mg dl−1; p = 0.025) and glucose tolerance (238 ± 50 vs. 217 ± 47 mg dl−1 h−1; p < 0.001), whereas these parameters did not change significantly in the control group. Eccentric exercise significantly improved triglyceride tolerance (1923 ± 1295 vs. 1670 ± 1085 mg dl−1 h−1; p = 0.003), whereas triglyceride tolerance remained unchanged in the control group (p = 0.819). Furthermore, body mass index (27.7 ± 4.3 vs. 27.4 ± 4.3 kg m−2; p = 0.003) and C-reactive protein (0.27 ± 0.42 vs. 0.23 ± 0.25 mg dl−1; p = 0.031) were significantly lowered in the eccentric exercise group but not in the control group. Downhill walking, a type of exercise is a promising unusual exercise modality with favorable effects on body mass index, insulin action, on postprandial glucose and triglyceride handling and on C-reactive protein. ClinicalTrials.gov Identifier: NCT00386854.
format	article
author	Heinz Drexel Arthur Mader Christoph H. Saely Gerda Tautermann Jörn F. Dopheide Alexander Vonbank
author_facet	Heinz Drexel Arthur Mader Christoph H. Saely Gerda Tautermann Jörn F. Dopheide Alexander Vonbank
author_sort	Heinz Drexel
title	Downhill hiking improves low-grade inflammation, triglycerides, body weight and glucose tolerance
title_short	Downhill hiking improves low-grade inflammation, triglycerides, body weight and glucose tolerance
title_full	Downhill hiking improves low-grade inflammation, triglycerides, body weight and glucose tolerance
title_fullStr	Downhill hiking improves low-grade inflammation, triglycerides, body weight and glucose tolerance
title_full_unstemmed	Downhill hiking improves low-grade inflammation, triglycerides, body weight and glucose tolerance
title_sort	downhill hiking improves low-grade inflammation, triglycerides, body weight and glucose tolerance
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/47b8753caab64ff99517d76123a1c43a
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Downhill hiking improves low-grade inflammation, triglycerides, body weight and glucose tolerance

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