Patient-specific induced pluripotent stem cells in neurological disease modeling: the importance of nonhuman primate models

Zhifang Qiu,1,2 Steven L Farnsworth,2 Anuja Mishra,1,2 Peter J Hornsby1,21Geriatric Research Education and Clinical Center, South Texas Veterans Health Care System, San Antonio, TX, USA; 2Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX, U...

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Autores principales:	Qiu Z, Farnsworth SL, Mishra A, Hornsby PJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Cytology QH573-671
Acceso en línea:	https://doaj.org/article/47bb70e1c14f4cbbb21386e64e367be2
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spelling	oai:doaj.org-article:47bb70e1c14f4cbbb21386e64e367be22021-12-02T05:07:14ZPatient-specific induced pluripotent stem cells in neurological disease modeling: the importance of nonhuman primate models1178-6957https://doaj.org/article/47bb70e1c14f4cbbb21386e64e367be22013-07-01T00:00:00Zhttp://www.dovepress.com/patient-specific-induced-pluripotent-stem-cells-in-neurological-diseas-a13559https://doaj.org/toc/1178-6957Zhifang Qiu,1,2 Steven L Farnsworth,2 Anuja Mishra,1,2 Peter J Hornsby1,21Geriatric Research Education and Clinical Center, South Texas Veterans Health Care System, San Antonio, TX, USA; 2Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX, USAAbstract: The development of the technology for derivation of induced pluripotent stem (iPS) cells from human patients and animal models has opened up new pathways to the better understanding of many human diseases, and has created new opportunities for therapeutic approaches. Here, we consider one important neurological disease, Parkinson's, the development of relevant neural cell lines for studying this disease, and the animal models that are available for testing the survival and function of the cells, following transplantation into the central nervous system. Rapid progress has been made recently in the application of protocols for neuroectoderm differentiation and neural patterning of pluripotent stem cells. These developments have resulted in the ability to produce large numbers of dopaminergic neurons with midbrain characteristics for further study. These cells have been shown to be functional in both rodent and nonhuman primate (NHP) models of Parkinson's disease. Patient-specific iPS cells and derived dopaminergic neurons have been developed, in particular from patients with genetic causes of Parkinson's disease. For complete modeling of the disease, it is proposed that the introduction of genetic changes into NHP iPS cells, followed by studying the phenotype of the genetic change in cells transplanted into the NHP as host animal, will yield new insights into disease processes not possible with rodent models alone.Keywords: Parkinson's disease, pluripotent cell differentiation, neural cell lines, dopaminergic neurons, cell transplantation, animal modelsQiu ZFarnsworth SLMishra AHornsby PJDove Medical PressarticleCytologyQH573-671ENStem Cells and Cloning: Advances and Applications, Vol 2013, Iss default, Pp 19-29 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cytology QH573-671
spellingShingle	Cytology QH573-671 Qiu Z Farnsworth SL Mishra A Hornsby PJ Patient-specific induced pluripotent stem cells in neurological disease modeling: the importance of nonhuman primate models
description	Zhifang Qiu,1,2 Steven L Farnsworth,2 Anuja Mishra,1,2 Peter J Hornsby1,21Geriatric Research Education and Clinical Center, South Texas Veterans Health Care System, San Antonio, TX, USA; 2Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX, USAAbstract: The development of the technology for derivation of induced pluripotent stem (iPS) cells from human patients and animal models has opened up new pathways to the better understanding of many human diseases, and has created new opportunities for therapeutic approaches. Here, we consider one important neurological disease, Parkinson's, the development of relevant neural cell lines for studying this disease, and the animal models that are available for testing the survival and function of the cells, following transplantation into the central nervous system. Rapid progress has been made recently in the application of protocols for neuroectoderm differentiation and neural patterning of pluripotent stem cells. These developments have resulted in the ability to produce large numbers of dopaminergic neurons with midbrain characteristics for further study. These cells have been shown to be functional in both rodent and nonhuman primate (NHP) models of Parkinson's disease. Patient-specific iPS cells and derived dopaminergic neurons have been developed, in particular from patients with genetic causes of Parkinson's disease. For complete modeling of the disease, it is proposed that the introduction of genetic changes into NHP iPS cells, followed by studying the phenotype of the genetic change in cells transplanted into the NHP as host animal, will yield new insights into disease processes not possible with rodent models alone.Keywords: Parkinson's disease, pluripotent cell differentiation, neural cell lines, dopaminergic neurons, cell transplantation, animal models
format	article
author	Qiu Z Farnsworth SL Mishra A Hornsby PJ
author_facet	Qiu Z Farnsworth SL Mishra A Hornsby PJ
author_sort	Qiu Z
title	Patient-specific induced pluripotent stem cells in neurological disease modeling: the importance of nonhuman primate models
title_short	Patient-specific induced pluripotent stem cells in neurological disease modeling: the importance of nonhuman primate models
title_full	Patient-specific induced pluripotent stem cells in neurological disease modeling: the importance of nonhuman primate models
title_fullStr	Patient-specific induced pluripotent stem cells in neurological disease modeling: the importance of nonhuman primate models
title_full_unstemmed	Patient-specific induced pluripotent stem cells in neurological disease modeling: the importance of nonhuman primate models
title_sort	patient-specific induced pluripotent stem cells in neurological disease modeling: the importance of nonhuman primate models
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/47bb70e1c14f4cbbb21386e64e367be2
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Patient-specific induced pluripotent stem cells in neurological disease modeling: the importance of nonhuman primate models

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