Elemental spatial and temporal association formation in left temporal lobe epilepsy.

The mesial temporal lobe (MTL) is typically understood as a memory structure in clinical settings, with the sine qua non of MTL damage in epilepsy being memory impairment. Recent models, however, understand memory as one of a number of higher cognitive functions that recruit the MTL through their re...

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Autores principales:	Christopher F A Benjamin, Michael M Saling, Amanda G Wood, David C Reutens
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/47bdd9b8c401407581e2ac41d5cf1f05
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spelling	oai:doaj.org-article:47bdd9b8c401407581e2ac41d5cf1f052021-11-25T06:10:20ZElemental spatial and temporal association formation in left temporal lobe epilepsy.1932-620310.1371/journal.pone.0100891https://doaj.org/article/47bdd9b8c401407581e2ac41d5cf1f052014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24978828/?tool=EBIhttps://doaj.org/toc/1932-6203The mesial temporal lobe (MTL) is typically understood as a memory structure in clinical settings, with the sine qua non of MTL damage in epilepsy being memory impairment. Recent models, however, understand memory as one of a number of higher cognitive functions that recruit the MTL through their reliance on more fundamental processes, such as "self-projection" or "association formation". We examined how damage to the left MTL influences these fundamental processes through the encoding of elemental spatial and temporal associations. We used a novel fMRI task to image the encoding of simple visual stimuli, either rich or impoverished, in spatial or spatial plus temporal information. Participants included 14 typical adults (36.4 years, sd. 10.5 years) and 14 patients with left mesial temporal lobe damage as evidenced by a clinical diagnosis of left temporal lobe epilepsy (TLE) and left MTL impairment on imaging (34.3 years, sd. 6.6 years). In-scanner behavioral performance was equivalent across groups. In the typical group whole-brain analysis revealed highly significant bilateral parahippocampal activation (right > left) during spatial associative processing and left hippocampal/parahippocampal deactivation in joint spatial-temporal associative processing. In the left TLE group identical analyses indicated patients used MTL structures contralateral to the seizure focus differently and relied on extra-MTL regions to a greater extent. These results are consistent with the notion that epileptogenic MTL damage is followed by reorganization of networks underlying elemental associative processes. In addition, they provide further evidence that task-related fMRI deactivation can meaningfully index brain function. The implications of these findings for clinical and cognitive neuropsychological models of MTL function in TLE are discussed.Christopher F A BenjaminMichael M SalingAmanda G WoodDavid C ReutensPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 6, p e100891 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Christopher F A Benjamin Michael M Saling Amanda G Wood David C Reutens Elemental spatial and temporal association formation in left temporal lobe epilepsy.
description	The mesial temporal lobe (MTL) is typically understood as a memory structure in clinical settings, with the sine qua non of MTL damage in epilepsy being memory impairment. Recent models, however, understand memory as one of a number of higher cognitive functions that recruit the MTL through their reliance on more fundamental processes, such as "self-projection" or "association formation". We examined how damage to the left MTL influences these fundamental processes through the encoding of elemental spatial and temporal associations. We used a novel fMRI task to image the encoding of simple visual stimuli, either rich or impoverished, in spatial or spatial plus temporal information. Participants included 14 typical adults (36.4 years, sd. 10.5 years) and 14 patients with left mesial temporal lobe damage as evidenced by a clinical diagnosis of left temporal lobe epilepsy (TLE) and left MTL impairment on imaging (34.3 years, sd. 6.6 years). In-scanner behavioral performance was equivalent across groups. In the typical group whole-brain analysis revealed highly significant bilateral parahippocampal activation (right > left) during spatial associative processing and left hippocampal/parahippocampal deactivation in joint spatial-temporal associative processing. In the left TLE group identical analyses indicated patients used MTL structures contralateral to the seizure focus differently and relied on extra-MTL regions to a greater extent. These results are consistent with the notion that epileptogenic MTL damage is followed by reorganization of networks underlying elemental associative processes. In addition, they provide further evidence that task-related fMRI deactivation can meaningfully index brain function. The implications of these findings for clinical and cognitive neuropsychological models of MTL function in TLE are discussed.
format	article
author	Christopher F A Benjamin Michael M Saling Amanda G Wood David C Reutens
author_facet	Christopher F A Benjamin Michael M Saling Amanda G Wood David C Reutens
author_sort	Christopher F A Benjamin
title	Elemental spatial and temporal association formation in left temporal lobe epilepsy.
title_short	Elemental spatial and temporal association formation in left temporal lobe epilepsy.
title_full	Elemental spatial and temporal association formation in left temporal lobe epilepsy.
title_fullStr	Elemental spatial and temporal association formation in left temporal lobe epilepsy.
title_full_unstemmed	Elemental spatial and temporal association formation in left temporal lobe epilepsy.
title_sort	elemental spatial and temporal association formation in left temporal lobe epilepsy.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/47bdd9b8c401407581e2ac41d5cf1f05
work_keys_str_mv	AT christopherfabenjamin elementalspatialandtemporalassociationformationinlefttemporallobeepilepsy AT michaelmsaling elementalspatialandtemporalassociationformationinlefttemporallobeepilepsy AT amandagwood elementalspatialandtemporalassociationformationinlefttemporallobeepilepsy AT davidcreutens elementalspatialandtemporalassociationformationinlefttemporallobeepilepsy
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Elemental spatial and temporal association formation in left temporal lobe epilepsy.

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