Oxytocin-pathway polygenic scores for severe mental disorders and metabolic phenotypes in the UK Biobank

Abstract Oxytocin is a neuromodulator and hormone that is typically associated with social cognition and behavior. In light of its purported effects on social cognition and behavior, research has investigated its potential as a treatment for psychiatric illnesses characterized by social dysfunction,...

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Autores principales:	Adriano Winterton, Francesco Bettella, Ann-Marie G. de Lange, Marit Haram, Nils Eiel Steen, Lars T. Westlye, Ole A. Andreassen, Daniel S. Quintana
Formato:	article
Lenguaje:	EN
Publicado:	Nature Publishing Group 2021
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/47be3e4285fe4751b001bd60dd929fae
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spelling	oai:doaj.org-article:47be3e4285fe4751b001bd60dd929fae2021-11-28T12:09:29ZOxytocin-pathway polygenic scores for severe mental disorders and metabolic phenotypes in the UK Biobank10.1038/s41398-021-01725-92158-3188https://doaj.org/article/47be3e4285fe4751b001bd60dd929fae2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41398-021-01725-9https://doaj.org/toc/2158-3188Abstract Oxytocin is a neuromodulator and hormone that is typically associated with social cognition and behavior. In light of its purported effects on social cognition and behavior, research has investigated its potential as a treatment for psychiatric illnesses characterized by social dysfunction, such as schizophrenia and bipolar disorder. While the results of these trials have been mixed, more recent evidence suggests that the oxytocin system is also linked with cardiometabolic conditions for which individuals with severe mental disorders are at a higher risk for developing. To investigate whether the oxytocin system has a pleiotropic effect on the etiology of severe mental illness and cardiometabolic conditions, we explored oxytocin’s role in the shared genetic liability of schizophrenia, bipolar disorder, type-2 diabetes, and several phenotypes linked with cardiovascular disease and type 2 diabetes risk using a polygenic pathway-specific approach. Analysis of a large sample with about 480,000 individuals (UK Biobank) revealed statistically significant associations across the range of phenotypes analyzed. By comparing these effects to those of polygenic scores calculated from 100 random gene sets, we also demonstrated the specificity of many of these significant results. Altogether, our results suggest that the shared effect of oxytocin-system dysfunction could help partially explain the co-occurrence of social and cardiometabolic dysfunction in severe mental illnesses.Adriano WintertonFrancesco BettellaAnn-Marie G. de LangeMarit HaramNils Eiel SteenLars T. WestlyeOle A. AndreassenDaniel S. QuintanaNature Publishing GrouparticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENTranslational Psychiatry, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Adriano Winterton Francesco Bettella Ann-Marie G. de Lange Marit Haram Nils Eiel Steen Lars T. Westlye Ole A. Andreassen Daniel S. Quintana Oxytocin-pathway polygenic scores for severe mental disorders and metabolic phenotypes in the UK Biobank
description	Abstract Oxytocin is a neuromodulator and hormone that is typically associated with social cognition and behavior. In light of its purported effects on social cognition and behavior, research has investigated its potential as a treatment for psychiatric illnesses characterized by social dysfunction, such as schizophrenia and bipolar disorder. While the results of these trials have been mixed, more recent evidence suggests that the oxytocin system is also linked with cardiometabolic conditions for which individuals with severe mental disorders are at a higher risk for developing. To investigate whether the oxytocin system has a pleiotropic effect on the etiology of severe mental illness and cardiometabolic conditions, we explored oxytocin’s role in the shared genetic liability of schizophrenia, bipolar disorder, type-2 diabetes, and several phenotypes linked with cardiovascular disease and type 2 diabetes risk using a polygenic pathway-specific approach. Analysis of a large sample with about 480,000 individuals (UK Biobank) revealed statistically significant associations across the range of phenotypes analyzed. By comparing these effects to those of polygenic scores calculated from 100 random gene sets, we also demonstrated the specificity of many of these significant results. Altogether, our results suggest that the shared effect of oxytocin-system dysfunction could help partially explain the co-occurrence of social and cardiometabolic dysfunction in severe mental illnesses.
format	article
author	Adriano Winterton Francesco Bettella Ann-Marie G. de Lange Marit Haram Nils Eiel Steen Lars T. Westlye Ole A. Andreassen Daniel S. Quintana
author_facet	Adriano Winterton Francesco Bettella Ann-Marie G. de Lange Marit Haram Nils Eiel Steen Lars T. Westlye Ole A. Andreassen Daniel S. Quintana
author_sort	Adriano Winterton
title	Oxytocin-pathway polygenic scores for severe mental disorders and metabolic phenotypes in the UK Biobank
title_short	Oxytocin-pathway polygenic scores for severe mental disorders and metabolic phenotypes in the UK Biobank
title_full	Oxytocin-pathway polygenic scores for severe mental disorders and metabolic phenotypes in the UK Biobank
title_fullStr	Oxytocin-pathway polygenic scores for severe mental disorders and metabolic phenotypes in the UK Biobank
title_full_unstemmed	Oxytocin-pathway polygenic scores for severe mental disorders and metabolic phenotypes in the UK Biobank
title_sort	oxytocin-pathway polygenic scores for severe mental disorders and metabolic phenotypes in the uk biobank
publisher	Nature Publishing Group
publishDate	2021
url	https://doaj.org/article/47be3e4285fe4751b001bd60dd929fae
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Oxytocin-pathway polygenic scores for severe mental disorders and metabolic phenotypes in the UK Biobank

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