Comparative genomics reveals contraction in olfactory receptor genes in bats

Abstract Gene loss and gain during genome evolution are thought to play important roles in adaptive phenotypic diversification. Among mammals, bats possess the smallest genomes and have evolved the unique abilities of powered flight and laryngeal echolocation. To investigate whether gene family evol...

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Autores principales:	Georgia Tsagkogeorga, Steven Müller, Christophe Dessimoz, Stephen J. Rossiter
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/47c021f2ef034c47a20df42ebcc0db20
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spelling	oai:doaj.org-article:47c021f2ef034c47a20df42ebcc0db202021-12-02T11:51:13ZComparative genomics reveals contraction in olfactory receptor genes in bats10.1038/s41598-017-00132-92045-2322https://doaj.org/article/47c021f2ef034c47a20df42ebcc0db202017-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00132-9https://doaj.org/toc/2045-2322Abstract Gene loss and gain during genome evolution are thought to play important roles in adaptive phenotypic diversification. Among mammals, bats possess the smallest genomes and have evolved the unique abilities of powered flight and laryngeal echolocation. To investigate whether gene family evolution has contributed to the genome downsizing and phenotypic diversification in this group, we performed comparative evolutionary analyses of complete proteome data for eight bat species, including echolocating and non-echolocating forms, together with the proteomes of 12 other laurasiatherian mammals. Our analyses revealed extensive gene loss in the most recent ancestor of bats, and also of carnivores (both >1,000 genes), although this gene contraction did not appear to correlate with the reduction in genome size in bats. Comparisons of highly dynamic families suggested that expansion and contraction affected genes with similar functions (immunity, response to stimulus) in all laurasiatherian lineages. However, the magnitude and direction of these changes varied greatly among groups. In particular, our results showed contraction of the Olfactory Receptor (OR) gene repertoire in the last common ancestor of all bats, as well as that of the echolocating species studied. In contrast, non-echolocating fruit bats showed evidence of expansion in ORs, supporting a “trade-off” between sensory modalities.Georgia TsagkogeorgaSteven MüllerChristophe DessimozStephen J. RossiterNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Georgia Tsagkogeorga Steven Müller Christophe Dessimoz Stephen J. Rossiter Comparative genomics reveals contraction in olfactory receptor genes in bats
description	Abstract Gene loss and gain during genome evolution are thought to play important roles in adaptive phenotypic diversification. Among mammals, bats possess the smallest genomes and have evolved the unique abilities of powered flight and laryngeal echolocation. To investigate whether gene family evolution has contributed to the genome downsizing and phenotypic diversification in this group, we performed comparative evolutionary analyses of complete proteome data for eight bat species, including echolocating and non-echolocating forms, together with the proteomes of 12 other laurasiatherian mammals. Our analyses revealed extensive gene loss in the most recent ancestor of bats, and also of carnivores (both >1,000 genes), although this gene contraction did not appear to correlate with the reduction in genome size in bats. Comparisons of highly dynamic families suggested that expansion and contraction affected genes with similar functions (immunity, response to stimulus) in all laurasiatherian lineages. However, the magnitude and direction of these changes varied greatly among groups. In particular, our results showed contraction of the Olfactory Receptor (OR) gene repertoire in the last common ancestor of all bats, as well as that of the echolocating species studied. In contrast, non-echolocating fruit bats showed evidence of expansion in ORs, supporting a “trade-off” between sensory modalities.
format	article
author	Georgia Tsagkogeorga Steven Müller Christophe Dessimoz Stephen J. Rossiter
author_facet	Georgia Tsagkogeorga Steven Müller Christophe Dessimoz Stephen J. Rossiter
author_sort	Georgia Tsagkogeorga
title	Comparative genomics reveals contraction in olfactory receptor genes in bats
title_short	Comparative genomics reveals contraction in olfactory receptor genes in bats
title_full	Comparative genomics reveals contraction in olfactory receptor genes in bats
title_fullStr	Comparative genomics reveals contraction in olfactory receptor genes in bats
title_full_unstemmed	Comparative genomics reveals contraction in olfactory receptor genes in bats
title_sort	comparative genomics reveals contraction in olfactory receptor genes in bats
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/47c021f2ef034c47a20df42ebcc0db20
work_keys_str_mv	AT georgiatsagkogeorga comparativegenomicsrevealscontractioninolfactoryreceptorgenesinbats AT stevenmuller comparativegenomicsrevealscontractioninolfactoryreceptorgenesinbats AT christophedessimoz comparativegenomicsrevealscontractioninolfactoryreceptorgenesinbats AT stephenjrossiter comparativegenomicsrevealscontractioninolfactoryreceptorgenesinbats
_version_	1718395160390270976

Comparative genomics reveals contraction in olfactory receptor genes in bats

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