Drug therapy of epileptic seizures among adult epileptic outpatients of University of Gondar Referral and Teaching Hospital, Gondar, North West Ethiopia

Eshetie Melese Birru,1 Miftah Shafi,2 Mestayet Geta11Department of Pharmacology, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; 2Department of Pharmacy, Health Science College, Mizan-Tepi University, Mizan Aman, Ethiopia Objective: The aim of this study was to asses...

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Autores principales:	Birru EM, Shafi M, Geta M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Key words: Anti-epileptics epilepsy treatment outcomes prescription patterns Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/47c2049cdbb34bd3ab0f246358e2a2da
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spelling	oai:doaj.org-article:47c2049cdbb34bd3ab0f246358e2a2da2021-12-02T06:29:45ZDrug therapy of epileptic seizures among adult epileptic outpatients of University of Gondar Referral and Teaching Hospital, Gondar, North West Ethiopia1178-2021https://doaj.org/article/47c2049cdbb34bd3ab0f246358e2a2da2016-12-01T00:00:00Zhttps://www.dovepress.com/drug-therapy-of-epileptic-seizures-among-adult-epileptic-outpatients-o-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Eshetie Melese Birru,1 Miftah Shafi,2 Mestayet Geta11Department of Pharmacology, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; 2Department of Pharmacy, Health Science College, Mizan-Tepi University, Mizan Aman, Ethiopia Objective: The aim of this study was to assess the practice of pharmacotherapy of epilepsy and its treatment outcomes in adult epileptic outpatients at the University of Gondar Referral and Teaching Hospital, Gondar, North West Ethiopia.Methods: An institution based, retrospective cross-sectional study was conducted from the medical charts of 336 adult epileptic patients at the outpatient epileptic clinic of Neurology Department of University of Gondar Teaching Hospital from May 2014 to April 2015. Reviewing follow-up information from the medical charts was used to evaluate antiepileptic drug (AED) prescribing patterns and treatment outcome. Data were collected by using data collection format and analyzed using SPSS software version 16.Results: The most common type of seizure diagnosed was generalized tonic–clonic seizure (n=245, 72.91%). Monotherapy with an AED accounted for 80.35% of the cases, whereas dual therapy and polytherapy with three AED combinations accounted for 16.37% and 3.28%, respectively. The most frequently prescribed AED was phenobarbitone (62.47%) followed by carbamazepine (17.91%). From the total epileptic cases, 277 (82.4%) had well-controlled seizure status in the last three consecutive months.Conclusion: Most of the patients were maintained by monotherapy, and largely this was by the older antiepileptic drug, phenobarbitone. Considering the development of pharmacotherapy of epilepsy and other patient related factors, the standard treatment guideline for Ethiopia needs to be revised periodically.Keywords: antiepileptics, epilepsy, treatment outcomes, prescription patternsBirru EMShafi MGeta MDove Medical PressarticleKey words: Anti-epilepticsepilepsytreatment outcomesprescription patternsNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 12, Pp 3213-3219 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Key words: Anti-epileptics epilepsy treatment outcomes prescription patterns Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Key words: Anti-epileptics epilepsy treatment outcomes prescription patterns Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Birru EM Shafi M Geta M Drug therapy of epileptic seizures among adult epileptic outpatients of University of Gondar Referral and Teaching Hospital, Gondar, North West Ethiopia
description	Eshetie Melese Birru,1 Miftah Shafi,2 Mestayet Geta11Department of Pharmacology, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; 2Department of Pharmacy, Health Science College, Mizan-Tepi University, Mizan Aman, Ethiopia Objective: The aim of this study was to assess the practice of pharmacotherapy of epilepsy and its treatment outcomes in adult epileptic outpatients at the University of Gondar Referral and Teaching Hospital, Gondar, North West Ethiopia.Methods: An institution based, retrospective cross-sectional study was conducted from the medical charts of 336 adult epileptic patients at the outpatient epileptic clinic of Neurology Department of University of Gondar Teaching Hospital from May 2014 to April 2015. Reviewing follow-up information from the medical charts was used to evaluate antiepileptic drug (AED) prescribing patterns and treatment outcome. Data were collected by using data collection format and analyzed using SPSS software version 16.Results: The most common type of seizure diagnosed was generalized tonic–clonic seizure (n=245, 72.91%). Monotherapy with an AED accounted for 80.35% of the cases, whereas dual therapy and polytherapy with three AED combinations accounted for 16.37% and 3.28%, respectively. The most frequently prescribed AED was phenobarbitone (62.47%) followed by carbamazepine (17.91%). From the total epileptic cases, 277 (82.4%) had well-controlled seizure status in the last three consecutive months.Conclusion: Most of the patients were maintained by monotherapy, and largely this was by the older antiepileptic drug, phenobarbitone. Considering the development of pharmacotherapy of epilepsy and other patient related factors, the standard treatment guideline for Ethiopia needs to be revised periodically.Keywords: antiepileptics, epilepsy, treatment outcomes, prescription patterns
format	article
author	Birru EM Shafi M Geta M
author_facet	Birru EM Shafi M Geta M
author_sort	Birru EM
title	Drug therapy of epileptic seizures among adult epileptic outpatients of University of Gondar Referral and Teaching Hospital, Gondar, North West Ethiopia
title_short	Drug therapy of epileptic seizures among adult epileptic outpatients of University of Gondar Referral and Teaching Hospital, Gondar, North West Ethiopia
title_full	Drug therapy of epileptic seizures among adult epileptic outpatients of University of Gondar Referral and Teaching Hospital, Gondar, North West Ethiopia
title_fullStr	Drug therapy of epileptic seizures among adult epileptic outpatients of University of Gondar Referral and Teaching Hospital, Gondar, North West Ethiopia
title_full_unstemmed	Drug therapy of epileptic seizures among adult epileptic outpatients of University of Gondar Referral and Teaching Hospital, Gondar, North West Ethiopia
title_sort	drug therapy of epileptic seizures among adult epileptic outpatients of university of gondar referral and teaching hospital, gondar, north west ethiopia
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/47c2049cdbb34bd3ab0f246358e2a2da
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Drug therapy of epileptic seizures among adult epileptic outpatients of University of Gondar Referral and Teaching Hospital, Gondar, North West Ethiopia

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