Circulating EGFL7 distinguishes between IUGR and PE: an observational case–control study

Abstract Isolated intrauterine growth restriction (IUGR) and preeclampsia (PE) share common placental pathogenesis. Differently from IUGR, PE is a systemic disorder which may also affect liver and brain. Early diagnosis of these conditions may optimize maternal and fetal management. Aim of this stud...

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Autores principales:	Micol Massimiani, Silvia Salvi, Grazia M. Tiralongo, Sascia Moresi, Heidi Stuhlmann, Herbert Valensise, Antonio Lanzone, Luisa Campagnolo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/47c5f2075dd04d439592009dedfa1d06
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spelling	oai:doaj.org-article:47c5f2075dd04d439592009dedfa1d062021-12-02T19:13:48ZCirculating EGFL7 distinguishes between IUGR and PE: an observational case–control study10.1038/s41598-021-97482-22045-2322https://doaj.org/article/47c5f2075dd04d439592009dedfa1d062021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97482-2https://doaj.org/toc/2045-2322Abstract Isolated intrauterine growth restriction (IUGR) and preeclampsia (PE) share common placental pathogenesis. Differently from IUGR, PE is a systemic disorder which may also affect liver and brain. Early diagnosis of these conditions may optimize maternal and fetal management. Aim of this study was to assess whether Epidermal Growth Factor-Like domain 7 (EGFL7) dosage in maternal blood discriminates between isolated IUGR and PE. A total of 116 women were enrolled in this case–control study: 12 non-pregnant women, 34 healthy pregnant women, 34 women presenting with isolated IUGR and 36 presenting with PE. Levels of circulating EGFL7 and other known pro- and anti-angiogenic factors were measured by ELISA at different gestational ages (GA). Between 22–25 weeks of gestation, EGFL7 levels in early-onset PE (e-PE) plasma samples were significantly higher than those measured in controls or isolated IUGR samples (69.86 ± 6.17 vs. 19.8 ± 2.5 or 18.8 ± 2.8 µg/ml, respectively). Between 26–34 weeks, EGFL7 levels remained significantly higher in e-PE compared to IUGR. At term, circulating and placental EGFL7 levels were comparable between IUGR and late-onset PE (l-PE). In contrast, circulating levels of PlGF were decreased in both IUGR- and PE- complicated pregnancies, while levels of both sFLT-1 and sENDOGLIN were increased in both conditions. In conclusion, EGFL7 significantly discriminates between isolated IUGR and PE.Micol MassimianiSilvia SalviGrazia M. TiralongoSascia MoresiHeidi StuhlmannHerbert ValensiseAntonio LanzoneLuisa CampagnoloNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Micol Massimiani Silvia Salvi Grazia M. Tiralongo Sascia Moresi Heidi Stuhlmann Herbert Valensise Antonio Lanzone Luisa Campagnolo Circulating EGFL7 distinguishes between IUGR and PE: an observational case–control study
description	Abstract Isolated intrauterine growth restriction (IUGR) and preeclampsia (PE) share common placental pathogenesis. Differently from IUGR, PE is a systemic disorder which may also affect liver and brain. Early diagnosis of these conditions may optimize maternal and fetal management. Aim of this study was to assess whether Epidermal Growth Factor-Like domain 7 (EGFL7) dosage in maternal blood discriminates between isolated IUGR and PE. A total of 116 women were enrolled in this case–control study: 12 non-pregnant women, 34 healthy pregnant women, 34 women presenting with isolated IUGR and 36 presenting with PE. Levels of circulating EGFL7 and other known pro- and anti-angiogenic factors were measured by ELISA at different gestational ages (GA). Between 22–25 weeks of gestation, EGFL7 levels in early-onset PE (e-PE) plasma samples were significantly higher than those measured in controls or isolated IUGR samples (69.86 ± 6.17 vs. 19.8 ± 2.5 or 18.8 ± 2.8 µg/ml, respectively). Between 26–34 weeks, EGFL7 levels remained significantly higher in e-PE compared to IUGR. At term, circulating and placental EGFL7 levels were comparable between IUGR and late-onset PE (l-PE). In contrast, circulating levels of PlGF were decreased in both IUGR- and PE- complicated pregnancies, while levels of both sFLT-1 and sENDOGLIN were increased in both conditions. In conclusion, EGFL7 significantly discriminates between isolated IUGR and PE.
format	article
author	Micol Massimiani Silvia Salvi Grazia M. Tiralongo Sascia Moresi Heidi Stuhlmann Herbert Valensise Antonio Lanzone Luisa Campagnolo
author_facet	Micol Massimiani Silvia Salvi Grazia M. Tiralongo Sascia Moresi Heidi Stuhlmann Herbert Valensise Antonio Lanzone Luisa Campagnolo
author_sort	Micol Massimiani
title	Circulating EGFL7 distinguishes between IUGR and PE: an observational case–control study
title_short	Circulating EGFL7 distinguishes between IUGR and PE: an observational case–control study
title_full	Circulating EGFL7 distinguishes between IUGR and PE: an observational case–control study
title_fullStr	Circulating EGFL7 distinguishes between IUGR and PE: an observational case–control study
title_full_unstemmed	Circulating EGFL7 distinguishes between IUGR and PE: an observational case–control study
title_sort	circulating egfl7 distinguishes between iugr and pe: an observational case–control study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/47c5f2075dd04d439592009dedfa1d06
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Circulating EGFL7 distinguishes between IUGR and PE: an observational case–control study

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