Dietary intake of tocopherols and risk of incident disabling dementia

Abstract Tocopherols, strong antioxidants, may be useful in preventing dementia, but the epidemiological evidence is insufficient. We performed a community-based follow-up study of Japanese, the Circulatory Risk in Community Study, involving 3739 people aged 40–64 years at baseline (1985–1999). Inci...

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Autores principales:	Shoko Aoki, Kazumasa Yamagishi, Koutatsu Maruyama, Rie Kishida, Ai Ikeda, Mitsumasa Umesawa, Cui Renzhe, Yasuhiko Kubota, Mina Hayama-Terada, Yuji Shimizu, Isao Muraki, Hironori Imano, Tomoko Sankai, Takeo Okada, Akihiko Kitamura, Masahiko Kiyama, Hiroyasu Iso
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/47c6aecdc16348a68bdcde0974da65bb
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spelling	oai:doaj.org-article:47c6aecdc16348a68bdcde0974da65bb2021-12-02T19:06:35ZDietary intake of tocopherols and risk of incident disabling dementia10.1038/s41598-021-95671-72045-2322https://doaj.org/article/47c6aecdc16348a68bdcde0974da65bb2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95671-7https://doaj.org/toc/2045-2322Abstract Tocopherols, strong antioxidants, may be useful in preventing dementia, but the epidemiological evidence is insufficient. We performed a community-based follow-up study of Japanese, the Circulatory Risk in Community Study, involving 3739 people aged 40–64 years at baseline (1985–1999). Incident disabling dementia was followed up from 1999 through 2020. For subtype analysis, we classified disabling dementia into that with and that without a history of stroke. Dietary intake of tocopherols (total, α, β, γ, and δ) were estimated using 24-h recall surveys. During a median follow-up of 19.7 years, 670 cases of disabling dementia developed. Total tocopherol intake was inversely associated with risk of disabling dementia with multivariable hazard ratios (95% confidence intervals) of 0.79 (0.63–1.00) for the highest versus lowest quartiles of total tocopherol intake (P for trend = 0.05). However, the association was strengthened when further adjusted for α-linolenic acid intake (Spearman correlation with total tocopherol intake = 0.93), with multivariable hazard ratios of 0.50 (0.34–0.74) (P for trend = 0.001) but was weakened and nonsignificant when further adjusted for linoleic acid intake (Spearman correlation with total tocopherol intake = 0.92), with multivariable hazard ratios of 0.69 (0.47–1.01) (P for trend = 0.05). Similar but nonsignificant inverse associations were observed for α-, γ-, and δ-tocopherols but not for β-tocopherol. These results were similar regardless of the presence of a history of stroke. Dietary tocopherol intake was inversely associated with risk of disabling dementia, but its independent effect was uncertain owing to a high intercorrelation of α-linolenic linoleic acids with total tocopherol intake. Even with such confounding, a diet high in tocopherols may help prevent the onset of dementia.Shoko AokiKazumasa YamagishiKoutatsu MaruyamaRie KishidaAi IkedaMitsumasa UmesawaCui RenzheYasuhiko KubotaMina Hayama-TeradaYuji ShimizuIsao MurakiHironori ImanoTomoko SankaiTakeo OkadaAkihiko KitamuraMasahiko KiyamaHiroyasu IsoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shoko Aoki Kazumasa Yamagishi Koutatsu Maruyama Rie Kishida Ai Ikeda Mitsumasa Umesawa Cui Renzhe Yasuhiko Kubota Mina Hayama-Terada Yuji Shimizu Isao Muraki Hironori Imano Tomoko Sankai Takeo Okada Akihiko Kitamura Masahiko Kiyama Hiroyasu Iso Dietary intake of tocopherols and risk of incident disabling dementia
description	Abstract Tocopherols, strong antioxidants, may be useful in preventing dementia, but the epidemiological evidence is insufficient. We performed a community-based follow-up study of Japanese, the Circulatory Risk in Community Study, involving 3739 people aged 40–64 years at baseline (1985–1999). Incident disabling dementia was followed up from 1999 through 2020. For subtype analysis, we classified disabling dementia into that with and that without a history of stroke. Dietary intake of tocopherols (total, α, β, γ, and δ) were estimated using 24-h recall surveys. During a median follow-up of 19.7 years, 670 cases of disabling dementia developed. Total tocopherol intake was inversely associated with risk of disabling dementia with multivariable hazard ratios (95% confidence intervals) of 0.79 (0.63–1.00) for the highest versus lowest quartiles of total tocopherol intake (P for trend = 0.05). However, the association was strengthened when further adjusted for α-linolenic acid intake (Spearman correlation with total tocopherol intake = 0.93), with multivariable hazard ratios of 0.50 (0.34–0.74) (P for trend = 0.001) but was weakened and nonsignificant when further adjusted for linoleic acid intake (Spearman correlation with total tocopherol intake = 0.92), with multivariable hazard ratios of 0.69 (0.47–1.01) (P for trend = 0.05). Similar but nonsignificant inverse associations were observed for α-, γ-, and δ-tocopherols but not for β-tocopherol. These results were similar regardless of the presence of a history of stroke. Dietary tocopherol intake was inversely associated with risk of disabling dementia, but its independent effect was uncertain owing to a high intercorrelation of α-linolenic linoleic acids with total tocopherol intake. Even with such confounding, a diet high in tocopherols may help prevent the onset of dementia.
format	article
author	Shoko Aoki Kazumasa Yamagishi Koutatsu Maruyama Rie Kishida Ai Ikeda Mitsumasa Umesawa Cui Renzhe Yasuhiko Kubota Mina Hayama-Terada Yuji Shimizu Isao Muraki Hironori Imano Tomoko Sankai Takeo Okada Akihiko Kitamura Masahiko Kiyama Hiroyasu Iso
author_facet	Shoko Aoki Kazumasa Yamagishi Koutatsu Maruyama Rie Kishida Ai Ikeda Mitsumasa Umesawa Cui Renzhe Yasuhiko Kubota Mina Hayama-Terada Yuji Shimizu Isao Muraki Hironori Imano Tomoko Sankai Takeo Okada Akihiko Kitamura Masahiko Kiyama Hiroyasu Iso
author_sort	Shoko Aoki
title	Dietary intake of tocopherols and risk of incident disabling dementia
title_short	Dietary intake of tocopherols and risk of incident disabling dementia
title_full	Dietary intake of tocopherols and risk of incident disabling dementia
title_fullStr	Dietary intake of tocopherols and risk of incident disabling dementia
title_full_unstemmed	Dietary intake of tocopherols and risk of incident disabling dementia
title_sort	dietary intake of tocopherols and risk of incident disabling dementia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/47c6aecdc16348a68bdcde0974da65bb
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Dietary intake of tocopherols and risk of incident disabling dementia

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