Disseminated intravascular coagulation immediately after trauma predicts a poor prognosis in severely injured patients
Abstract Trauma patients die from massive bleeding due to disseminated intravascular coagulation (DIC) with a fibrinolytic phenotype in the early phase, which transforms to DIC with a thrombotic phenotype in the late phase of trauma, contributing to the development of multiple organ dysfunction synd...
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Nature Portfolio
2021
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oai:doaj.org-article:47c70ae2ab164612893ea0c2ca46829f2021-12-02T16:53:10ZDisseminated intravascular coagulation immediately after trauma predicts a poor prognosis in severely injured patients10.1038/s41598-021-90492-02045-2322https://doaj.org/article/47c70ae2ab164612893ea0c2ca46829f2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90492-0https://doaj.org/toc/2045-2322Abstract Trauma patients die from massive bleeding due to disseminated intravascular coagulation (DIC) with a fibrinolytic phenotype in the early phase, which transforms to DIC with a thrombotic phenotype in the late phase of trauma, contributing to the development of multiple organ dysfunction syndrome (MODS) and a consequently poor outcome. This is a sub-analysis of a multicenter prospective descriptive cross-sectional study on DIC to evaluate the effect of a DIC diagnosis on the survival probability and predictive performance of DIC scores for massive transfusion, MODS, and hospital death in severely injured trauma patients. A DIC diagnosis on admission was associated with a lower survival probability (Log Rank P < 0.001), higher frequency of massive transfusion and MODS and a higher mortality rate than no such diagnosis. The DIC scores at 0 and 3 h significantly predicted massive transfusion, MODS, and hospital death. Markers of thrombin and plasmin generation and fibrinolysis inhibition also showed a good predictive ability for these three items. In conclusion, a DIC diagnosis on admission was associated with a low survival probability. DIC scores obtained immediately after trauma predicted a poor prognosis of severely injured trauma patients.Takeshi WadaAtsushi ShiraishiSatoshi GandoKazuma YamakawaSeitaro FujishimaDaizoh SaitohShigeki KushimotoHiroshi OguraToshikazu AbeToshihiko MayumiJunichi SasakiJoji KotaniNaoshi TakeyamaRyosuke TsurutaKiyotsugu TakumaNorio YamashitaShin-ichiro ShiraishiHiroto IkedaYasukazu ShiinoTakehiko TaruiTaka-aki NakadaToru HifumiKohji OkamotoYuichiro SakamotoAkiyoshi HagiwaraTomohiko MasunoMasashi UeyamaSatoshi FujimiYutaka UmemuraYasuhiro OtomoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021) |
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DOAJ |
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DOAJ |
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EN |
| topic |
Medicine R Science Q |
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Medicine R Science Q Takeshi Wada Atsushi Shiraishi Satoshi Gando Kazuma Yamakawa Seitaro Fujishima Daizoh Saitoh Shigeki Kushimoto Hiroshi Ogura Toshikazu Abe Toshihiko Mayumi Junichi Sasaki Joji Kotani Naoshi Takeyama Ryosuke Tsuruta Kiyotsugu Takuma Norio Yamashita Shin-ichiro Shiraishi Hiroto Ikeda Yasukazu Shiino Takehiko Tarui Taka-aki Nakada Toru Hifumi Kohji Okamoto Yuichiro Sakamoto Akiyoshi Hagiwara Tomohiko Masuno Masashi Ueyama Satoshi Fujimi Yutaka Umemura Yasuhiro Otomo Disseminated intravascular coagulation immediately after trauma predicts a poor prognosis in severely injured patients |
| description |
Abstract Trauma patients die from massive bleeding due to disseminated intravascular coagulation (DIC) with a fibrinolytic phenotype in the early phase, which transforms to DIC with a thrombotic phenotype in the late phase of trauma, contributing to the development of multiple organ dysfunction syndrome (MODS) and a consequently poor outcome. This is a sub-analysis of a multicenter prospective descriptive cross-sectional study on DIC to evaluate the effect of a DIC diagnosis on the survival probability and predictive performance of DIC scores for massive transfusion, MODS, and hospital death in severely injured trauma patients. A DIC diagnosis on admission was associated with a lower survival probability (Log Rank P < 0.001), higher frequency of massive transfusion and MODS and a higher mortality rate than no such diagnosis. The DIC scores at 0 and 3 h significantly predicted massive transfusion, MODS, and hospital death. Markers of thrombin and plasmin generation and fibrinolysis inhibition also showed a good predictive ability for these three items. In conclusion, a DIC diagnosis on admission was associated with a low survival probability. DIC scores obtained immediately after trauma predicted a poor prognosis of severely injured trauma patients. |
| format |
article |
| author |
Takeshi Wada Atsushi Shiraishi Satoshi Gando Kazuma Yamakawa Seitaro Fujishima Daizoh Saitoh Shigeki Kushimoto Hiroshi Ogura Toshikazu Abe Toshihiko Mayumi Junichi Sasaki Joji Kotani Naoshi Takeyama Ryosuke Tsuruta Kiyotsugu Takuma Norio Yamashita Shin-ichiro Shiraishi Hiroto Ikeda Yasukazu Shiino Takehiko Tarui Taka-aki Nakada Toru Hifumi Kohji Okamoto Yuichiro Sakamoto Akiyoshi Hagiwara Tomohiko Masuno Masashi Ueyama Satoshi Fujimi Yutaka Umemura Yasuhiro Otomo |
| author_facet |
Takeshi Wada Atsushi Shiraishi Satoshi Gando Kazuma Yamakawa Seitaro Fujishima Daizoh Saitoh Shigeki Kushimoto Hiroshi Ogura Toshikazu Abe Toshihiko Mayumi Junichi Sasaki Joji Kotani Naoshi Takeyama Ryosuke Tsuruta Kiyotsugu Takuma Norio Yamashita Shin-ichiro Shiraishi Hiroto Ikeda Yasukazu Shiino Takehiko Tarui Taka-aki Nakada Toru Hifumi Kohji Okamoto Yuichiro Sakamoto Akiyoshi Hagiwara Tomohiko Masuno Masashi Ueyama Satoshi Fujimi Yutaka Umemura Yasuhiro Otomo |
| author_sort |
Takeshi Wada |
| title |
Disseminated intravascular coagulation immediately after trauma predicts a poor prognosis in severely injured patients |
| title_short |
Disseminated intravascular coagulation immediately after trauma predicts a poor prognosis in severely injured patients |
| title_full |
Disseminated intravascular coagulation immediately after trauma predicts a poor prognosis in severely injured patients |
| title_fullStr |
Disseminated intravascular coagulation immediately after trauma predicts a poor prognosis in severely injured patients |
| title_full_unstemmed |
Disseminated intravascular coagulation immediately after trauma predicts a poor prognosis in severely injured patients |
| title_sort |
disseminated intravascular coagulation immediately after trauma predicts a poor prognosis in severely injured patients |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/47c70ae2ab164612893ea0c2ca46829f |
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