Microemulsions vs chitosan derivative-coated microemulsions for dermal delivery of 8-methoxypsoralen

Jun-Yong Wu,1–3,* Yong-Jiang Li,1–3,* Ting-Ting Liu,1–3 Ge Ou,1–3 Xiong-Bin Hu,1–3 Tian-Tian Tang,1–3 Jie-Min Wang,1–3 Xin-Yi Liu,1–3 Da-Xiong Xiang1–3 1Department of Pharmacy, Second Xiangya Hospital, Central...

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Autores principales:	Wu JY, Li YJ, Liu TT, Ou G, Hu XB, Tang TT, Wang JM, Liu XY, Xiang DX
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Vitiligo 8-methoxypsoralen microemulsion chitosan coated microemulsion ex vivo permeation microdialysis pharmacokinetics Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/47c88b189ccd48e3ba281bf36de9696b
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spelling	oai:doaj.org-article:47c88b189ccd48e3ba281bf36de9696b2021-12-02T03:15:59ZMicroemulsions vs chitosan derivative-coated microemulsions for dermal delivery of 8-methoxypsoralen1178-2013https://doaj.org/article/47c88b189ccd48e3ba281bf36de9696b2019-04-01T00:00:00Zhttps://www.dovepress.com/microemulsions-vs-chitosan-derivative-coated-microemulsions-for-dermal-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Jun-Yong Wu,1–3,* Yong-Jiang Li,1–3,* Ting-Ting Liu,1–3 Ge Ou,1–3 Xiong-Bin Hu,1–3 Tian-Tian Tang,1–3 Jie-Min Wang,1–3 Xin-Yi Liu,1–3 Da-Xiong Xiang1–3 1Department of Pharmacy, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, People’s Republic of China; 2Institute of Clinical Pharmacy, Central South University, Changsha, Hunan 410011, People’s Republic of China; 3Hunan Provincial Engineering Research Center of Translational Medicine and Innovative Drugs, Changsha, Hunan, People’s Republic of China *These authors contributed equally to this work Background: 8-methoxypsoralen (8-MOP) is one of the most commonly utilized drugs in psoralen-ultraviolet A therapy for treatment of vitiligo. However, poor skin retention and systemic side effects limit the clinical application of 8-MOP. Methods: Microemulsions (MEs) and chitosan derivative-coated 8-MOP MEs were developed and compared for dermal delivery of 8-MOP. Ex vivo skin retention/permeation study was performed to select the ME formulation with the highest retention:permeation ratio. Four different chitosan-coated MEs were prepared and compared with the ME formulation for their ability to distribute 8-MOP in the skin.Results: Among various ME formulations developed, a formulation containing 2.9% ethyl oleate, 17.2% Cromophor EL35, 8.6% ethanol and 71.3% water showed the highest ex vivo skin retention:permeation ratio (1.98). Of four chitosan-coated MEs prepared, carboxymethyl chitosan-coated MEs (CC-MEs) and hydroxypropyl chitosan-coated MEs (HC-MEs) showed higher ex vivo skin retention:permeation ratio (1.46 and 1.84). and were selected for in vivo pharmacokinetic study. AUCskin (0–12 h) for 8-MOP MEs (4578.56 h·ng·mL-1) was higher than HC-MEs (3422.47 h·ng·mL-1), CC-MEs (2808.51 h·ng·mL-1) and tincture (1500.16 h·ng·mL-1). Also, AUCplasma (0–12 h) for MEs (39.35±13.90 h·ng·mL-1) was significantly lower than HC-MEs (66.32 h·ng·mL-1), CC-MEs (59.70 h·ng·mL-1) and tincture (73.02 h·ng·mL-1).Conclusion: These combined results suggested that the MEs developed could be a promising and safe alternative for targeted skin delivery of 8-MOP. Keywords: 8-methoxypsoralen, microemulsion, chitosan-coated microemulsion, ex vivo permeation, microdialysis, pharmacokineticsWu JYLi YJLiu TTOu GHu XBTang TTWang JMLiu XYXiang DXDove Medical PressarticleVitiligo8-methoxypsoralenmicroemulsionchitosan coated microemulsionex vivo permeationmicrodialysispharmacokineticsMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 2327-2340 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Vitiligo 8-methoxypsoralen microemulsion chitosan coated microemulsion ex vivo permeation microdialysis pharmacokinetics Medicine (General) R5-920
spellingShingle	Vitiligo 8-methoxypsoralen microemulsion chitosan coated microemulsion ex vivo permeation microdialysis pharmacokinetics Medicine (General) R5-920 Wu JY Li YJ Liu TT Ou G Hu XB Tang TT Wang JM Liu XY Xiang DX Microemulsions vs chitosan derivative-coated microemulsions for dermal delivery of 8-methoxypsoralen
description	Jun-Yong Wu,1–3,* Yong-Jiang Li,1–3,* Ting-Ting Liu,1–3 Ge Ou,1–3 Xiong-Bin Hu,1–3 Tian-Tian Tang,1–3 Jie-Min Wang,1–3 Xin-Yi Liu,1–3 Da-Xiong Xiang1–3 1Department of Pharmacy, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, People’s Republic of China; 2Institute of Clinical Pharmacy, Central South University, Changsha, Hunan 410011, People’s Republic of China; 3Hunan Provincial Engineering Research Center of Translational Medicine and Innovative Drugs, Changsha, Hunan, People’s Republic of China *These authors contributed equally to this work Background: 8-methoxypsoralen (8-MOP) is one of the most commonly utilized drugs in psoralen-ultraviolet A therapy for treatment of vitiligo. However, poor skin retention and systemic side effects limit the clinical application of 8-MOP. Methods: Microemulsions (MEs) and chitosan derivative-coated 8-MOP MEs were developed and compared for dermal delivery of 8-MOP. Ex vivo skin retention/permeation study was performed to select the ME formulation with the highest retention:permeation ratio. Four different chitosan-coated MEs were prepared and compared with the ME formulation for their ability to distribute 8-MOP in the skin.Results: Among various ME formulations developed, a formulation containing 2.9% ethyl oleate, 17.2% Cromophor EL35, 8.6% ethanol and 71.3% water showed the highest ex vivo skin retention:permeation ratio (1.98). Of four chitosan-coated MEs prepared, carboxymethyl chitosan-coated MEs (CC-MEs) and hydroxypropyl chitosan-coated MEs (HC-MEs) showed higher ex vivo skin retention:permeation ratio (1.46 and 1.84). and were selected for in vivo pharmacokinetic study. AUCskin (0–12 h) for 8-MOP MEs (4578.56 h·ng·mL-1) was higher than HC-MEs (3422.47 h·ng·mL-1), CC-MEs (2808.51 h·ng·mL-1) and tincture (1500.16 h·ng·mL-1). Also, AUCplasma (0–12 h) for MEs (39.35±13.90 h·ng·mL-1) was significantly lower than HC-MEs (66.32 h·ng·mL-1), CC-MEs (59.70 h·ng·mL-1) and tincture (73.02 h·ng·mL-1).Conclusion: These combined results suggested that the MEs developed could be a promising and safe alternative for targeted skin delivery of 8-MOP. Keywords: 8-methoxypsoralen, microemulsion, chitosan-coated microemulsion, ex vivo permeation, microdialysis, pharmacokinetics
format	article
author	Wu JY Li YJ Liu TT Ou G Hu XB Tang TT Wang JM Liu XY Xiang DX
author_facet	Wu JY Li YJ Liu TT Ou G Hu XB Tang TT Wang JM Liu XY Xiang DX
author_sort	Wu JY
title	Microemulsions vs chitosan derivative-coated microemulsions for dermal delivery of 8-methoxypsoralen
title_short	Microemulsions vs chitosan derivative-coated microemulsions for dermal delivery of 8-methoxypsoralen
title_full	Microemulsions vs chitosan derivative-coated microemulsions for dermal delivery of 8-methoxypsoralen
title_fullStr	Microemulsions vs chitosan derivative-coated microemulsions for dermal delivery of 8-methoxypsoralen
title_full_unstemmed	Microemulsions vs chitosan derivative-coated microemulsions for dermal delivery of 8-methoxypsoralen
title_sort	microemulsions vs chitosan derivative-coated microemulsions for dermal delivery of 8-methoxypsoralen
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/47c88b189ccd48e3ba281bf36de9696b
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Microemulsions vs chitosan derivative-coated microemulsions for dermal delivery of 8-methoxypsoralen

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