Loss of UBE3A from TH-expressing neurons suppresses GABA co-release and enhances VTA-NAc optical self-stimulation

Mesoaccumbal terminals within the VTA are known to co-release both GABA and dopamine, although the functional role of the former has yet to be determined. Here, the authors find that non-canonical GABA release is regulated by the E3-ubiquitin ligase, UBE3A, and enhances optogenetic self-stimulation.

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Autores principales:	Janet Berrios, Alice M. Stamatakis, Pranish A. Kantak, Zoe A. McElligott, Matthew C. Judson, Megumi Aita, Marie Rougie, Garret D. Stuber, Benjamin D. Philpot
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/47c9bd33a98d49e9a2cb7661abd7a002
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spelling	oai:doaj.org-article:47c9bd33a98d49e9a2cb7661abd7a0022021-12-02T14:39:49ZLoss of UBE3A from TH-expressing neurons suppresses GABA co-release and enhances VTA-NAc optical self-stimulation10.1038/ncomms107022041-1723https://doaj.org/article/47c9bd33a98d49e9a2cb7661abd7a0022016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10702https://doaj.org/toc/2041-1723Mesoaccumbal terminals within the VTA are known to co-release both GABA and dopamine, although the functional role of the former has yet to be determined. Here, the authors find that non-canonical GABA release is regulated by the E3-ubiquitin ligase, UBE3A, and enhances optogenetic self-stimulation.Janet BerriosAlice M. StamatakisPranish A. KantakZoe A. McElligottMatthew C. JudsonMegumi AitaMarie RougieGarret D. StuberBenjamin D. PhilpotNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Janet Berrios Alice M. Stamatakis Pranish A. Kantak Zoe A. McElligott Matthew C. Judson Megumi Aita Marie Rougie Garret D. Stuber Benjamin D. Philpot Loss of UBE3A from TH-expressing neurons suppresses GABA co-release and enhances VTA-NAc optical self-stimulation
description	Mesoaccumbal terminals within the VTA are known to co-release both GABA and dopamine, although the functional role of the former has yet to be determined. Here, the authors find that non-canonical GABA release is regulated by the E3-ubiquitin ligase, UBE3A, and enhances optogenetic self-stimulation.
format	article
author	Janet Berrios Alice M. Stamatakis Pranish A. Kantak Zoe A. McElligott Matthew C. Judson Megumi Aita Marie Rougie Garret D. Stuber Benjamin D. Philpot
author_facet	Janet Berrios Alice M. Stamatakis Pranish A. Kantak Zoe A. McElligott Matthew C. Judson Megumi Aita Marie Rougie Garret D. Stuber Benjamin D. Philpot
author_sort	Janet Berrios
title	Loss of UBE3A from TH-expressing neurons suppresses GABA co-release and enhances VTA-NAc optical self-stimulation
title_short	Loss of UBE3A from TH-expressing neurons suppresses GABA co-release and enhances VTA-NAc optical self-stimulation
title_full	Loss of UBE3A from TH-expressing neurons suppresses GABA co-release and enhances VTA-NAc optical self-stimulation
title_fullStr	Loss of UBE3A from TH-expressing neurons suppresses GABA co-release and enhances VTA-NAc optical self-stimulation
title_full_unstemmed	Loss of UBE3A from TH-expressing neurons suppresses GABA co-release and enhances VTA-NAc optical self-stimulation
title_sort	loss of ube3a from th-expressing neurons suppresses gaba co-release and enhances vta-nac optical self-stimulation
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/47c9bd33a98d49e9a2cb7661abd7a002
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Loss of UBE3A from TH-expressing neurons suppresses GABA co-release and enhances VTA-NAc optical self-stimulation

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