Loss of UBE3A from TH-expressing neurons suppresses GABA co-release and enhances VTA-NAc optical self-stimulation

Loss of UBE3A from TH-expressing neurons suppresses GABA co-release and enhances VTA-NAc optical self-stimulation

Mesoaccumbal terminals within the VTA are known to co-release both GABA and dopamine, although the functional role of the former has yet to be determined. Here, the authors find that non-canonical GABA release is regulated by the E3-ubiquitin ligase, UBE3A, and enhances optogenetic self-stimulation.

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Detalles Bibliográficos
Autores principales: Janet Berrios, Alice M. Stamatakis, Pranish A. Kantak, Zoe A. McElligott, Matthew C. Judson, Megumi Aita, Marie Rougie, Garret D. Stuber, Benjamin D. Philpot
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/47c9bd33a98d49e9a2cb7661abd7a002
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