Role of endocannabinoids in regulating drug dependence
Daniela Parolaro, Daniela Vigano’, Natalia Realini, Tiziana RubinoNeuroscience Center, DBSF, University of Insubria, Busto Arsizio, ItalyAbstract: This review will discuss the latest knowledge of how the endocannabinoid system might be involved in treating addiction to the most common...
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Dove Medical Press
2007
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oai:doaj.org-article:47d168f14dda4e23b9535c4723651f832021-12-02T02:58:28ZRole of endocannabinoids in regulating drug dependence1176-63281178-2021https://doaj.org/article/47d168f14dda4e23b9535c4723651f832007-01-01T00:00:00Zhttp://www.dovepress.com/role-of-endocannabinoids-in-regulating-drug-dependence-a950https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Daniela Parolaro, Daniela Vigano’, Natalia Realini, Tiziana RubinoNeuroscience Center, DBSF, University of Insubria, Busto Arsizio, ItalyAbstract: This review will discuss the latest knowledge of how the endocannabinoid system might be involved in treating addiction to the most common illicit drugs. Experimental models are providing increasing evidence for the pharmacological management of endocannabinoid signaling not only to block the direct reinforcing effects of cannabis, opioids, nicotine and ethanol, but also for preventing relapse to the various drugs of abuse, including opioids, cocaine, nicotine, alcohol and metamphetamine. Preclinical and clinical studies suggest that the endocannabinoid system can be manipulated by the CB1 receptor antagonist SR141716A, that might constitute a new generation of compounds for treating addiction across different classes of abused drugs.Keywords: Endocannabinoids, drug dependence, opioids, nicotine, alcohol, psychostimulants Daniela ParolaroDaniela Vigano’Natalia RealiniTiziana RubinoDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2007, Iss Issue 6, Pp 711-721 (2007) |
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DOAJ |
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EN |
| topic |
Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Daniela Parolaro Daniela Vigano’ Natalia Realini Tiziana Rubino Role of endocannabinoids in regulating drug dependence |
| description |
Daniela Parolaro, Daniela Vigano’, Natalia Realini, Tiziana RubinoNeuroscience Center, DBSF, University of Insubria, Busto Arsizio, ItalyAbstract: This review will discuss the latest knowledge of how the endocannabinoid system might be involved in treating addiction to the most common illicit drugs. Experimental models are providing increasing evidence for the pharmacological management of endocannabinoid signaling not only to block the direct reinforcing effects of cannabis, opioids, nicotine and ethanol, but also for preventing relapse to the various drugs of abuse, including opioids, cocaine, nicotine, alcohol and metamphetamine. Preclinical and clinical studies suggest that the endocannabinoid system can be manipulated by the CB1 receptor antagonist SR141716A, that might constitute a new generation of compounds for treating addiction across different classes of abused drugs.Keywords: Endocannabinoids, drug dependence, opioids, nicotine, alcohol, psychostimulants |
| format |
article |
| author |
Daniela Parolaro Daniela Vigano’ Natalia Realini Tiziana Rubino |
| author_facet |
Daniela Parolaro Daniela Vigano’ Natalia Realini Tiziana Rubino |
| author_sort |
Daniela Parolaro |
| title |
Role of endocannabinoids in regulating drug dependence |
| title_short |
Role of endocannabinoids in regulating drug dependence |
| title_full |
Role of endocannabinoids in regulating drug dependence |
| title_fullStr |
Role of endocannabinoids in regulating drug dependence |
| title_full_unstemmed |
Role of endocannabinoids in regulating drug dependence |
| title_sort |
role of endocannabinoids in regulating drug dependence |
| publisher |
Dove Medical Press |
| publishDate |
2007 |
| url |
https://doaj.org/article/47d168f14dda4e23b9535c4723651f83 |
| work_keys_str_mv |
AT danielaparolaro roleofendocannabinoidsinregulatingdrugdependence AT danielaviganoamprsquo roleofendocannabinoidsinregulatingdrugdependence AT nataliarealini roleofendocannabinoidsinregulatingdrugdependence AT tizianarubino roleofendocannabinoidsinregulatingdrugdependence |
| _version_ |
1718402039183048704 |