The genomic ancestry of individuals from different geographical regions of Brazil is more uniform than expected.

Based on pre-DNA racial/color methodology, clinical and pharmacological trials have traditionally considered the different geographical regions of Brazil as being very heterogeneous. We wished to ascertain how such diversity of regional color categories correlated with ancestry. Using a panel of 40...

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Autores principales:	Sérgio D J Pena, Giuliano Di Pietro, Mateus Fuchshuber-Moraes, Julia Pasqualini Genro, Mara H Hutz, Fernanda de Souza Gomes Kehdy, Fabiana Kohlrausch, Luiz Alexandre Viana Magno, Raquel Carvalho Montenegro, Manoel Odorico Moraes, Maria Elisabete Amaral de Moraes, Milene Raiol de Moraes, Elida B Ojopi, Jamila A Perini, Clarice Racciopi, Andrea Kely Campos Ribeiro-Dos-Santos, Fabrício Rios-Santos, Marco A Romano-Silva, Vinicius A Sortica, Guilherme Suarez-Kurtz
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/47d5071fbd074d108b6a70080571e9a6
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spelling	oai:doaj.org-article:47d5071fbd074d108b6a70080571e9a62021-11-18T06:58:40ZThe genomic ancestry of individuals from different geographical regions of Brazil is more uniform than expected.1932-620310.1371/journal.pone.0017063https://doaj.org/article/47d5071fbd074d108b6a70080571e9a62011-02-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21359226/?tool=EBIhttps://doaj.org/toc/1932-6203Based on pre-DNA racial/color methodology, clinical and pharmacological trials have traditionally considered the different geographical regions of Brazil as being very heterogeneous. We wished to ascertain how such diversity of regional color categories correlated with ancestry. Using a panel of 40 validated ancestry-informative insertion-deletion DNA polymorphisms we estimated individually the European, African and Amerindian ancestry components of 934 self-categorized White, Brown or Black Brazilians from the four most populous regions of the Country. We unraveled great ancestral diversity between and within the different regions. Especially, color categories in the northern part of Brazil diverged significantly in their ancestry proportions from their counterparts in the southern part of the Country, indicating that diverse regional semantics were being used in the self-classification as White, Brown or Black. To circumvent these regional subjective differences in color perception, we estimated the general ancestry proportions of each of the four regions in a form independent of color considerations. For that, we multiplied the proportions of a given ancestry in a given color category by the official census information about the proportion of that color category in the specific region, to arrive at a "total ancestry" estimate. Once such a calculation was performed, there emerged a much higher level of uniformity than previously expected. In all regions studied, the European ancestry was predominant, with proportions ranging from 60.6% in the Northeast to 77.7% in the South. We propose that the immigration of six million Europeans to Brazil in the 19th and 20th centuries--a phenomenon described and intended as the "whitening of Brazil"--is in large part responsible for dissipating previous ancestry dissimilarities that reflected region-specific population histories. These findings, of both clinical and sociological importance for Brazil, should also be relevant to other countries with ancestrally admixed populations.Sérgio D J PenaGiuliano Di PietroMateus Fuchshuber-MoraesJulia Pasqualini GenroMara H HutzFernanda de Souza Gomes KehdyFabiana KohlrauschLuiz Alexandre Viana MagnoRaquel Carvalho MontenegroManoel Odorico MoraesMaria Elisabete Amaral de MoraesMilene Raiol de MoraesElida B OjopiJamila A PeriniClarice RacciopiAndrea Kely Campos Ribeiro-Dos-SantosFabrício Rios-SantosMarco A Romano-SilvaVinicius A SorticaGuilherme Suarez-KurtzPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 2, p e17063 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sérgio D J Pena Giuliano Di Pietro Mateus Fuchshuber-Moraes Julia Pasqualini Genro Mara H Hutz Fernanda de Souza Gomes Kehdy Fabiana Kohlrausch Luiz Alexandre Viana Magno Raquel Carvalho Montenegro Manoel Odorico Moraes Maria Elisabete Amaral de Moraes Milene Raiol de Moraes Elida B Ojopi Jamila A Perini Clarice Racciopi Andrea Kely Campos Ribeiro-Dos-Santos Fabrício Rios-Santos Marco A Romano-Silva Vinicius A Sortica Guilherme Suarez-Kurtz The genomic ancestry of individuals from different geographical regions of Brazil is more uniform than expected.
description	Based on pre-DNA racial/color methodology, clinical and pharmacological trials have traditionally considered the different geographical regions of Brazil as being very heterogeneous. We wished to ascertain how such diversity of regional color categories correlated with ancestry. Using a panel of 40 validated ancestry-informative insertion-deletion DNA polymorphisms we estimated individually the European, African and Amerindian ancestry components of 934 self-categorized White, Brown or Black Brazilians from the four most populous regions of the Country. We unraveled great ancestral diversity between and within the different regions. Especially, color categories in the northern part of Brazil diverged significantly in their ancestry proportions from their counterparts in the southern part of the Country, indicating that diverse regional semantics were being used in the self-classification as White, Brown or Black. To circumvent these regional subjective differences in color perception, we estimated the general ancestry proportions of each of the four regions in a form independent of color considerations. For that, we multiplied the proportions of a given ancestry in a given color category by the official census information about the proportion of that color category in the specific region, to arrive at a "total ancestry" estimate. Once such a calculation was performed, there emerged a much higher level of uniformity than previously expected. In all regions studied, the European ancestry was predominant, with proportions ranging from 60.6% in the Northeast to 77.7% in the South. We propose that the immigration of six million Europeans to Brazil in the 19th and 20th centuries--a phenomenon described and intended as the "whitening of Brazil"--is in large part responsible for dissipating previous ancestry dissimilarities that reflected region-specific population histories. These findings, of both clinical and sociological importance for Brazil, should also be relevant to other countries with ancestrally admixed populations.
format	article
author	Sérgio D J Pena Giuliano Di Pietro Mateus Fuchshuber-Moraes Julia Pasqualini Genro Mara H Hutz Fernanda de Souza Gomes Kehdy Fabiana Kohlrausch Luiz Alexandre Viana Magno Raquel Carvalho Montenegro Manoel Odorico Moraes Maria Elisabete Amaral de Moraes Milene Raiol de Moraes Elida B Ojopi Jamila A Perini Clarice Racciopi Andrea Kely Campos Ribeiro-Dos-Santos Fabrício Rios-Santos Marco A Romano-Silva Vinicius A Sortica Guilherme Suarez-Kurtz
author_facet	Sérgio D J Pena Giuliano Di Pietro Mateus Fuchshuber-Moraes Julia Pasqualini Genro Mara H Hutz Fernanda de Souza Gomes Kehdy Fabiana Kohlrausch Luiz Alexandre Viana Magno Raquel Carvalho Montenegro Manoel Odorico Moraes Maria Elisabete Amaral de Moraes Milene Raiol de Moraes Elida B Ojopi Jamila A Perini Clarice Racciopi Andrea Kely Campos Ribeiro-Dos-Santos Fabrício Rios-Santos Marco A Romano-Silva Vinicius A Sortica Guilherme Suarez-Kurtz
author_sort	Sérgio D J Pena
title	The genomic ancestry of individuals from different geographical regions of Brazil is more uniform than expected.
title_short	The genomic ancestry of individuals from different geographical regions of Brazil is more uniform than expected.
title_full	The genomic ancestry of individuals from different geographical regions of Brazil is more uniform than expected.
title_fullStr	The genomic ancestry of individuals from different geographical regions of Brazil is more uniform than expected.
title_full_unstemmed	The genomic ancestry of individuals from different geographical regions of Brazil is more uniform than expected.
title_sort	genomic ancestry of individuals from different geographical regions of brazil is more uniform than expected.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/47d5071fbd074d108b6a70080571e9a6
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The genomic ancestry of individuals from different geographical regions of Brazil is more uniform than expected.

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