Structural basis of myelin-associated glycoprotein adhesion and signalling

Myelin-associated glycoprotein (MAG) maintains myelin-axon spacing. Here, the authors report the crystal structures of the MAG full ectodomain in complex with oligosaccharide, and use additional assays to provide insights into the mechanism of MAG-mediated signalling.

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Autores principales:	Matti F. Pronker, Suzanne Lemstra, Joost Snijder, Albert J. R. Heck, Dominique M. E. Thies-Weesie, R. Jeroen Pasterkamp, Bert J. C. Janssen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/47da9cf46c964aaaa66b8ca1a8ddde26
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spelling	oai:doaj.org-article:47da9cf46c964aaaa66b8ca1a8ddde262021-12-02T16:57:04ZStructural basis of myelin-associated glycoprotein adhesion and signalling10.1038/ncomms135842041-1723https://doaj.org/article/47da9cf46c964aaaa66b8ca1a8ddde262016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13584https://doaj.org/toc/2041-1723Myelin-associated glycoprotein (MAG) maintains myelin-axon spacing. Here, the authors report the crystal structures of the MAG full ectodomain in complex with oligosaccharide, and use additional assays to provide insights into the mechanism of MAG-mediated signalling.Matti F. PronkerSuzanne LemstraJoost SnijderAlbert J. R. HeckDominique M. E. Thies-WeesieR. Jeroen PasterkampBert J. C. JanssenNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Matti F. Pronker Suzanne Lemstra Joost Snijder Albert J. R. Heck Dominique M. E. Thies-Weesie R. Jeroen Pasterkamp Bert J. C. Janssen Structural basis of myelin-associated glycoprotein adhesion and signalling
description	Myelin-associated glycoprotein (MAG) maintains myelin-axon spacing. Here, the authors report the crystal structures of the MAG full ectodomain in complex with oligosaccharide, and use additional assays to provide insights into the mechanism of MAG-mediated signalling.
format	article
author	Matti F. Pronker Suzanne Lemstra Joost Snijder Albert J. R. Heck Dominique M. E. Thies-Weesie R. Jeroen Pasterkamp Bert J. C. Janssen
author_facet	Matti F. Pronker Suzanne Lemstra Joost Snijder Albert J. R. Heck Dominique M. E. Thies-Weesie R. Jeroen Pasterkamp Bert J. C. Janssen
author_sort	Matti F. Pronker
title	Structural basis of myelin-associated glycoprotein adhesion and signalling
title_short	Structural basis of myelin-associated glycoprotein adhesion and signalling
title_full	Structural basis of myelin-associated glycoprotein adhesion and signalling
title_fullStr	Structural basis of myelin-associated glycoprotein adhesion and signalling
title_full_unstemmed	Structural basis of myelin-associated glycoprotein adhesion and signalling
title_sort	structural basis of myelin-associated glycoprotein adhesion and signalling
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/47da9cf46c964aaaa66b8ca1a8ddde26
work_keys_str_mv	AT mattifpronker structuralbasisofmyelinassociatedglycoproteinadhesionandsignalling AT suzannelemstra structuralbasisofmyelinassociatedglycoproteinadhesionandsignalling AT joostsnijder structuralbasisofmyelinassociatedglycoproteinadhesionandsignalling AT albertjrheck structuralbasisofmyelinassociatedglycoproteinadhesionandsignalling AT dominiquemethiesweesie structuralbasisofmyelinassociatedglycoproteinadhesionandsignalling AT rjeroenpasterkamp structuralbasisofmyelinassociatedglycoproteinadhesionandsignalling AT bertjcjanssen structuralbasisofmyelinassociatedglycoproteinadhesionandsignalling
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Structural basis of myelin-associated glycoprotein adhesion and signalling

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