Particle deposition in a child respiratory tract model: in vivo regional deposition of fine and ultrafine aerosols in baboons.

To relate exposure to adverse health effects, it is necessary to know where particles in the submicron range deposit in the respiratory tract. The possibly higher vulnerability of children requires specific inhalation studies. However, radio-aerosol deposition experiments involving children are rare...

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Autores principales:	Iolanda Albuquerque-Silva, Laurent Vecellio, Marc Durand, John Avet, Déborah Le Pennec, Michèle de Monte, Jérôme Montharu, Patrice Diot, Michèle Cottier, Francis Dubois, Jérémie Pourchez
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/47dd0735a78e4dfbb0605ee9e6472dcb
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spelling	oai:doaj.org-article:47dd0735a78e4dfbb0605ee9e6472dcb2021-11-18T08:21:18ZParticle deposition in a child respiratory tract model: in vivo regional deposition of fine and ultrafine aerosols in baboons.1932-620310.1371/journal.pone.0095456https://doaj.org/article/47dd0735a78e4dfbb0605ee9e6472dcb2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24787744/?tool=EBIhttps://doaj.org/toc/1932-6203To relate exposure to adverse health effects, it is necessary to know where particles in the submicron range deposit in the respiratory tract. The possibly higher vulnerability of children requires specific inhalation studies. However, radio-aerosol deposition experiments involving children are rare because of ethical restrictions related to radiation exposure. Thus, an in vivo study was conducted using three baboons as a child respiratory tract model to assess regional deposition patterns (thoracic region vs. extrathoracic region) of radioactive polydisperse aerosols ([d16-d84], equal to [0.15 µm-0.5 µm], [0.25 µm-1 µm], or [1 µm-9 µm]). Results clearly demonstrated that aerosol deposition within the thoracic region and the extrathoraic region varied substantially according to particle size. High deposition in the extrathoracic region was observed for the [1 µm-9 µm] aerosol (72% ± 17%). The [0.15 µm-0.5 µm] aerosol was associated almost exclusively with thoracic region deposition (84% ± 4%). Airborne particles in the range of [0.25 µm-1 µm] showed an intermediate deposition pattern, with 49% ± 8% in the extrathoracic region and 51% ± 8% in the thoracic region. Finally, comparison of baboon and human inhalation experiments for the [1 µm-9 µm] aerosol showed similar regional deposition, leading to the conclusion that regional deposition is species-independent for this airborne particle sizes.Iolanda Albuquerque-SilvaLaurent VecellioMarc DurandJohn AvetDéborah Le PennecMichèle de MonteJérôme MontharuPatrice DiotMichèle CottierFrancis DuboisJérémie PourchezJérémie PourchezPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 4, p e95456 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Iolanda Albuquerque-Silva Laurent Vecellio Marc Durand John Avet Déborah Le Pennec Michèle de Monte Jérôme Montharu Patrice Diot Michèle Cottier Francis Dubois Jérémie Pourchez Jérémie Pourchez Particle deposition in a child respiratory tract model: in vivo regional deposition of fine and ultrafine aerosols in baboons.
description	To relate exposure to adverse health effects, it is necessary to know where particles in the submicron range deposit in the respiratory tract. The possibly higher vulnerability of children requires specific inhalation studies. However, radio-aerosol deposition experiments involving children are rare because of ethical restrictions related to radiation exposure. Thus, an in vivo study was conducted using three baboons as a child respiratory tract model to assess regional deposition patterns (thoracic region vs. extrathoracic region) of radioactive polydisperse aerosols ([d16-d84], equal to [0.15 µm-0.5 µm], [0.25 µm-1 µm], or [1 µm-9 µm]). Results clearly demonstrated that aerosol deposition within the thoracic region and the extrathoraic region varied substantially according to particle size. High deposition in the extrathoracic region was observed for the [1 µm-9 µm] aerosol (72% ± 17%). The [0.15 µm-0.5 µm] aerosol was associated almost exclusively with thoracic region deposition (84% ± 4%). Airborne particles in the range of [0.25 µm-1 µm] showed an intermediate deposition pattern, with 49% ± 8% in the extrathoracic region and 51% ± 8% in the thoracic region. Finally, comparison of baboon and human inhalation experiments for the [1 µm-9 µm] aerosol showed similar regional deposition, leading to the conclusion that regional deposition is species-independent for this airborne particle sizes.
format	article
author	Iolanda Albuquerque-Silva Laurent Vecellio Marc Durand John Avet Déborah Le Pennec Michèle de Monte Jérôme Montharu Patrice Diot Michèle Cottier Francis Dubois Jérémie Pourchez Jérémie Pourchez
author_facet	Iolanda Albuquerque-Silva Laurent Vecellio Marc Durand John Avet Déborah Le Pennec Michèle de Monte Jérôme Montharu Patrice Diot Michèle Cottier Francis Dubois Jérémie Pourchez Jérémie Pourchez
author_sort	Iolanda Albuquerque-Silva
title	Particle deposition in a child respiratory tract model: in vivo regional deposition of fine and ultrafine aerosols in baboons.
title_short	Particle deposition in a child respiratory tract model: in vivo regional deposition of fine and ultrafine aerosols in baboons.
title_full	Particle deposition in a child respiratory tract model: in vivo regional deposition of fine and ultrafine aerosols in baboons.
title_fullStr	Particle deposition in a child respiratory tract model: in vivo regional deposition of fine and ultrafine aerosols in baboons.
title_full_unstemmed	Particle deposition in a child respiratory tract model: in vivo regional deposition of fine and ultrafine aerosols in baboons.
title_sort	particle deposition in a child respiratory tract model: in vivo regional deposition of fine and ultrafine aerosols in baboons.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/47dd0735a78e4dfbb0605ee9e6472dcb
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Particle deposition in a child respiratory tract model: in vivo regional deposition of fine and ultrafine aerosols in baboons.

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