Optimized antimicrobial and antiproliferative activities of titanate nanofibers containing silver

Yong Hua Su*, Zi Fei Yin*, Hai Liang Xin, Hui Qing Zhang, Jia Yu Sheng, Yan Long Yang, Juan Du, Chang Quan LingDepartment of Traditional Chinese Medicine, Changhai Hospital, The Second Military Medical University, Shanghai, People&rsquo;s Republic of China*These authors contributed equallyAb...

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Autores principales:	Su YH, Yin ZF, Xin HL, Zhang HQ, Sheng JY, Yang YL, Du J, Ling CQ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/47dd2475b9764aa98a1bcdd3ff7f95cc
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spelling	oai:doaj.org-article:47dd2475b9764aa98a1bcdd3ff7f95cc2021-12-02T02:42:32ZOptimized antimicrobial and antiproliferative activities of titanate nanofibers containing silver1176-91141178-2013https://doaj.org/article/47dd2475b9764aa98a1bcdd3ff7f95cc2011-08-01T00:00:00Zhttp://www.dovepress.com/optimized-antimicrobial-and-antiproliferative-activities-of-titanate-n-a7998https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Yong Hua Su, Zi Fei Yin, Hai Liang Xin, Hui Qing Zhang, Jia Yu Sheng, Yan Long Yang, Juan Du, Chang Quan LingDepartment of Traditional Chinese Medicine, Changhai Hospital, The Second Military Medical University, Shanghai, People&rsquo;s Republic of China*These authors contributed equallyAbstract: Titanate nanofibers containing silver have been demonstrated through the experiments reported herein to have effective antifungal and antiproliferative activities in the presence of UV light. The titanate nanofibers containing silver can be fabricated by means of ion exchange followed by a topochemical process in an environment suitable for reductive reactions. Excellent antibacterial, antifungal, and antiproliferative activities could be demonstrated by both Ag2Ti5O11&nbsp;&middot; xH2O and Ag/titanate (UV light irradiation) due to their unique structures and compositions, which have photocatalytic activities to generate reactive oxygen species and capabilities to continuously release the silver ions. Therefore these materials have the potential to produce a membrane for the treatment of superficial malignant tumor, esophageal cancer, or cervical carcinoma. They may also hold utility if incorporated into a coating on stents in moderate and advanced stage esophageal carcinoma or for endoscopic retrograde biliary drainage. These approaches may significantly reduce infections, inhibit tumor growth, and importantly, improve quality of life and prolong survival time for patients with tumors.Keywords: silver, titanate, photocatalytic, antiproliferative, antimicrobialSu YHYin ZFXin HLZhang HQSheng JYYang YLDu JLing CQDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2011, Iss default, Pp 1579-1586 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Su YH Yin ZF Xin HL Zhang HQ Sheng JY Yang YL Du J Ling CQ Optimized antimicrobial and antiproliferative activities of titanate nanofibers containing silver
description	Yong Hua Su, Zi Fei Yin, Hai Liang Xin, Hui Qing Zhang, Jia Yu Sheng, Yan Long Yang, Juan Du, Chang Quan LingDepartment of Traditional Chinese Medicine, Changhai Hospital, The Second Military Medical University, Shanghai, People&rsquo;s Republic of China*These authors contributed equallyAbstract: Titanate nanofibers containing silver have been demonstrated through the experiments reported herein to have effective antifungal and antiproliferative activities in the presence of UV light. The titanate nanofibers containing silver can be fabricated by means of ion exchange followed by a topochemical process in an environment suitable for reductive reactions. Excellent antibacterial, antifungal, and antiproliferative activities could be demonstrated by both Ag2Ti5O11&nbsp;&middot; xH2O and Ag/titanate (UV light irradiation) due to their unique structures and compositions, which have photocatalytic activities to generate reactive oxygen species and capabilities to continuously release the silver ions. Therefore these materials have the potential to produce a membrane for the treatment of superficial malignant tumor, esophageal cancer, or cervical carcinoma. They may also hold utility if incorporated into a coating on stents in moderate and advanced stage esophageal carcinoma or for endoscopic retrograde biliary drainage. These approaches may significantly reduce infections, inhibit tumor growth, and importantly, improve quality of life and prolong survival time for patients with tumors.Keywords: silver, titanate, photocatalytic, antiproliferative, antimicrobial
format	article
author	Su YH Yin ZF Xin HL Zhang HQ Sheng JY Yang YL Du J Ling CQ
author_facet	Su YH Yin ZF Xin HL Zhang HQ Sheng JY Yang YL Du J Ling CQ
author_sort	Su YH
title	Optimized antimicrobial and antiproliferative activities of titanate nanofibers containing silver
title_short	Optimized antimicrobial and antiproliferative activities of titanate nanofibers containing silver
title_full	Optimized antimicrobial and antiproliferative activities of titanate nanofibers containing silver
title_fullStr	Optimized antimicrobial and antiproliferative activities of titanate nanofibers containing silver
title_full_unstemmed	Optimized antimicrobial and antiproliferative activities of titanate nanofibers containing silver
title_sort	optimized antimicrobial and antiproliferative activities of titanate nanofibers containing silver
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/47dd2475b9764aa98a1bcdd3ff7f95cc
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Optimized antimicrobial and antiproliferative activities of titanate nanofibers containing silver

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