Case Report: Dual Target Deep Brain Stimulation With Externalized Programming for Post-traumatic Complex Movement Disorder

Introduction: Movement disorders can be common, persistent, and debilitating sequelae of severe traumatic brain injury. Post-traumatic movement disorders are usually complex in nature, involving multiple phenomenological manifestations, and can be difficult to control with medical management alone....

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Autores principales: Ron Gadot, Ben Shofty, Ricardo A. Najera, Adrish Anand, Garrett Banks, Abdul Basit Khan, Melissa A. LoPresti, Nora Vanegas Arroyave, Sameer A. Sheth
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Publicado: Frontiers Media S.A. 2021
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spelling oai:doaj.org-article:47ded2afbda94caa98872ab37a5cbcc02021-11-08T07:58:38ZCase Report: Dual Target Deep Brain Stimulation With Externalized Programming for Post-traumatic Complex Movement Disorder1662-453X10.3389/fnins.2021.774073https://doaj.org/article/47ded2afbda94caa98872ab37a5cbcc02021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnins.2021.774073/fullhttps://doaj.org/toc/1662-453XIntroduction: Movement disorders can be common, persistent, and debilitating sequelae of severe traumatic brain injury. Post-traumatic movement disorders are usually complex in nature, involving multiple phenomenological manifestations, and can be difficult to control with medical management alone. Deep brain stimulation (DBS) has been used to treat these challenging cases, but distorted brain anatomy secondary to trauma can complicate effective targeting. In such cases, use of diffusion tractography imaging and inpatient testing with externalized DBS leads can be beneficial in optimizing outcomes.Case Description: We present the case of a 42-year-old man with severe, disabling post-traumatic tremor who underwent bilateral, dual target DBS to the globus pallidus internus (GPi) and a combined ventral intermediate nucleus of the thalamus (Vim)/dentato-rubro-thalamic tracts (DRTT) target. DRTT fiber tracts were reconstructed preoperatively to assist in surgical targeting given the patient’s distorted anatomy. Externalization and survey of the four leads extra-operatively with inpatient testing allowed for internalization of the leads that demonstrated benefit. Six months after surgery, the patient’s tremor and dystonic burden had decreased by 67% in the performance sub-score of The Essential Tremor Rating Scale (TETRAS).Conclusion: A patient-tailored approach including target selection guided by individualized anatomy and tractography as well as extra-operative externalized lead interrogation was shown to be effective in optimizing clinical outcome in a patient with refractory post-traumatic tremor.Ron GadotBen ShoftyRicardo A. NajeraAdrish AnandGarrett BanksAbdul Basit KhanMelissa A. LoPrestiNora Vanegas ArroyaveSameer A. ShethFrontiers Media S.A.articledeep brain stimulationtraumatremormovement disorderDRTT = dentato-rubro-thalamic tractNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Neuroscience, Vol 15 (2021)
institution DOAJ
collection DOAJ
language EN
topic deep brain stimulation
trauma
tremor
movement disorder
DRTT = dentato-rubro-thalamic tract
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
spellingShingle deep brain stimulation
trauma
tremor
movement disorder
DRTT = dentato-rubro-thalamic tract
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Ron Gadot
Ben Shofty
Ricardo A. Najera
Adrish Anand
Garrett Banks
Abdul Basit Khan
Melissa A. LoPresti
Nora Vanegas Arroyave
Sameer A. Sheth
Case Report: Dual Target Deep Brain Stimulation With Externalized Programming for Post-traumatic Complex Movement Disorder
description Introduction: Movement disorders can be common, persistent, and debilitating sequelae of severe traumatic brain injury. Post-traumatic movement disorders are usually complex in nature, involving multiple phenomenological manifestations, and can be difficult to control with medical management alone. Deep brain stimulation (DBS) has been used to treat these challenging cases, but distorted brain anatomy secondary to trauma can complicate effective targeting. In such cases, use of diffusion tractography imaging and inpatient testing with externalized DBS leads can be beneficial in optimizing outcomes.Case Description: We present the case of a 42-year-old man with severe, disabling post-traumatic tremor who underwent bilateral, dual target DBS to the globus pallidus internus (GPi) and a combined ventral intermediate nucleus of the thalamus (Vim)/dentato-rubro-thalamic tracts (DRTT) target. DRTT fiber tracts were reconstructed preoperatively to assist in surgical targeting given the patient’s distorted anatomy. Externalization and survey of the four leads extra-operatively with inpatient testing allowed for internalization of the leads that demonstrated benefit. Six months after surgery, the patient’s tremor and dystonic burden had decreased by 67% in the performance sub-score of The Essential Tremor Rating Scale (TETRAS).Conclusion: A patient-tailored approach including target selection guided by individualized anatomy and tractography as well as extra-operative externalized lead interrogation was shown to be effective in optimizing clinical outcome in a patient with refractory post-traumatic tremor.
format article
author Ron Gadot
Ben Shofty
Ricardo A. Najera
Adrish Anand
Garrett Banks
Abdul Basit Khan
Melissa A. LoPresti
Nora Vanegas Arroyave
Sameer A. Sheth
author_facet Ron Gadot
Ben Shofty
Ricardo A. Najera
Adrish Anand
Garrett Banks
Abdul Basit Khan
Melissa A. LoPresti
Nora Vanegas Arroyave
Sameer A. Sheth
author_sort Ron Gadot
title Case Report: Dual Target Deep Brain Stimulation With Externalized Programming for Post-traumatic Complex Movement Disorder
title_short Case Report: Dual Target Deep Brain Stimulation With Externalized Programming for Post-traumatic Complex Movement Disorder
title_full Case Report: Dual Target Deep Brain Stimulation With Externalized Programming for Post-traumatic Complex Movement Disorder
title_fullStr Case Report: Dual Target Deep Brain Stimulation With Externalized Programming for Post-traumatic Complex Movement Disorder
title_full_unstemmed Case Report: Dual Target Deep Brain Stimulation With Externalized Programming for Post-traumatic Complex Movement Disorder
title_sort case report: dual target deep brain stimulation with externalized programming for post-traumatic complex movement disorder
publisher Frontiers Media S.A.
publishDate 2021
url https://doaj.org/article/47ded2afbda94caa98872ab37a5cbcc0
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