Association of heart-type fatty acid-binding protein with cardiovascular risk factors and all-cause mortality in the general population: the Takahata study.
<h4>Background</h4>Despite many recent advances in medicine, preventing the development of cardiovascular diseases remains a challenge. Heart-type fatty acid-binding protein (H-FABP) is a marker of ongoing myocardial damage and has been reported to be a useful indicator for future cardio...
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2014
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oai:doaj.org-article:47e30bdce71c4c8cb6fcae623e6e5b502021-11-18T08:18:31ZAssociation of heart-type fatty acid-binding protein with cardiovascular risk factors and all-cause mortality in the general population: the Takahata study.1932-620310.1371/journal.pone.0094834https://doaj.org/article/47e30bdce71c4c8cb6fcae623e6e5b502014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24847804/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Despite many recent advances in medicine, preventing the development of cardiovascular diseases remains a challenge. Heart-type fatty acid-binding protein (H-FABP) is a marker of ongoing myocardial damage and has been reported to be a useful indicator for future cardiovascular events. However, it remains to be determined whether H-FABP can predict all-cause and cardiovascular deaths in the general population.<h4>Methods and results</h4>This longitudinal cohort study included 3,503 subjects who participated in a community-based health checkup with a 7-year follow-up. Serum H-FABP was measured in registered subjects. The results demonstrated that higher H-FABP levels were associated with increasing numbers of cardiovascular risk factors, including hypertension, diabetes mellitus, obesity, and metabolic syndrome. There were 158 deaths during the follow-up period, including 50 cardiovascular deaths. Deceased subjects had higher H-FABP levels compared to surviving subjects. Multivariate Cox proportional hazard regression analysis revealed that H-FABP is an independent predictor of all-cause and cardiovascular deaths after adjustments for confounding factors. Subjects were divided into four quartiles according to H-FABP level, and Kaplan-Meier analysis demonstrated that the highest H-FABP quartile was associated with the greatest risks for all-cause and cardiovascular deaths. Net reclassification index and integrated discrimination index were significantly increased by addition of H-FABP to cardiovascular risk factors.<h4>Conclusions</h4>H-FABP level was increased in association with greater numbers of cardiovascular risk factors and was an independent risk factor for all-cause and cardiovascular deaths. H-FABP could be a useful indicator for the early identification of high-risk subjects in the general population.Yoichiro OtakiTetsu WatanabeHiroki TakahashiAtushi HirayamaTaro NarumiShinpei KadowakiYuki HondaTakanori ArimotoTetsuro ShishidoTakuya MiyamotoTsuneo KontaYoko ShibataAkira FukaoMakoto DaimonYoshiyuki UenoTakeo KatoTakamasa KayamaIsao KubotaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 5, p e94834 (2014) |
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Medicine R Science Q Yoichiro Otaki Tetsu Watanabe Hiroki Takahashi Atushi Hirayama Taro Narumi Shinpei Kadowaki Yuki Honda Takanori Arimoto Tetsuro Shishido Takuya Miyamoto Tsuneo Konta Yoko Shibata Akira Fukao Makoto Daimon Yoshiyuki Ueno Takeo Kato Takamasa Kayama Isao Kubota Association of heart-type fatty acid-binding protein with cardiovascular risk factors and all-cause mortality in the general population: the Takahata study. |
| description |
<h4>Background</h4>Despite many recent advances in medicine, preventing the development of cardiovascular diseases remains a challenge. Heart-type fatty acid-binding protein (H-FABP) is a marker of ongoing myocardial damage and has been reported to be a useful indicator for future cardiovascular events. However, it remains to be determined whether H-FABP can predict all-cause and cardiovascular deaths in the general population.<h4>Methods and results</h4>This longitudinal cohort study included 3,503 subjects who participated in a community-based health checkup with a 7-year follow-up. Serum H-FABP was measured in registered subjects. The results demonstrated that higher H-FABP levels were associated with increasing numbers of cardiovascular risk factors, including hypertension, diabetes mellitus, obesity, and metabolic syndrome. There were 158 deaths during the follow-up period, including 50 cardiovascular deaths. Deceased subjects had higher H-FABP levels compared to surviving subjects. Multivariate Cox proportional hazard regression analysis revealed that H-FABP is an independent predictor of all-cause and cardiovascular deaths after adjustments for confounding factors. Subjects were divided into four quartiles according to H-FABP level, and Kaplan-Meier analysis demonstrated that the highest H-FABP quartile was associated with the greatest risks for all-cause and cardiovascular deaths. Net reclassification index and integrated discrimination index were significantly increased by addition of H-FABP to cardiovascular risk factors.<h4>Conclusions</h4>H-FABP level was increased in association with greater numbers of cardiovascular risk factors and was an independent risk factor for all-cause and cardiovascular deaths. H-FABP could be a useful indicator for the early identification of high-risk subjects in the general population. |
| format |
article |
| author |
Yoichiro Otaki Tetsu Watanabe Hiroki Takahashi Atushi Hirayama Taro Narumi Shinpei Kadowaki Yuki Honda Takanori Arimoto Tetsuro Shishido Takuya Miyamoto Tsuneo Konta Yoko Shibata Akira Fukao Makoto Daimon Yoshiyuki Ueno Takeo Kato Takamasa Kayama Isao Kubota |
| author_facet |
Yoichiro Otaki Tetsu Watanabe Hiroki Takahashi Atushi Hirayama Taro Narumi Shinpei Kadowaki Yuki Honda Takanori Arimoto Tetsuro Shishido Takuya Miyamoto Tsuneo Konta Yoko Shibata Akira Fukao Makoto Daimon Yoshiyuki Ueno Takeo Kato Takamasa Kayama Isao Kubota |
| author_sort |
Yoichiro Otaki |
| title |
Association of heart-type fatty acid-binding protein with cardiovascular risk factors and all-cause mortality in the general population: the Takahata study. |
| title_short |
Association of heart-type fatty acid-binding protein with cardiovascular risk factors and all-cause mortality in the general population: the Takahata study. |
| title_full |
Association of heart-type fatty acid-binding protein with cardiovascular risk factors and all-cause mortality in the general population: the Takahata study. |
| title_fullStr |
Association of heart-type fatty acid-binding protein with cardiovascular risk factors and all-cause mortality in the general population: the Takahata study. |
| title_full_unstemmed |
Association of heart-type fatty acid-binding protein with cardiovascular risk factors and all-cause mortality in the general population: the Takahata study. |
| title_sort |
association of heart-type fatty acid-binding protein with cardiovascular risk factors and all-cause mortality in the general population: the takahata study. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2014 |
| url |
https://doaj.org/article/47e30bdce71c4c8cb6fcae623e6e5b50 |
| work_keys_str_mv |
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