Rapid endothelial cytoskeletal reorganization enables early blood–brain barrier disruption and long-term ischaemic reperfusion brain injury

Rapid endothelial cytoskeletal reorganization enables early blood–brain barrier disruption and long-term ischaemic reperfusion brain injury

Matrix metalloproteinases (MMPs) released from infiltrating immune cells are a major contributor to blood-brain barrier (BBB) breakdown following stroke. Here, the authors identify an early, MMP-independent BBB breakdown mechanism caused by rapid cytoskeletal rearrangements in endothelial cells, whi...

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Autores principales: Yejie Shi, Lili Zhang, Hongjian Pu, Leilei Mao, Xiaoming Hu, Xiaoyan Jiang, Na Xu, R. Anne Stetler, Feng Zhang, Xiangrong Liu, Rehana K. Leak, Richard F. Keep, Xunming Ji, Jun Chen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/47e5d60a78ef44e5b0ac4d3e29177a21
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spelling oai:doaj.org-article:47e5d60a78ef44e5b0ac4d3e29177a212021-12-02T15:34:50ZRapid endothelial cytoskeletal reorganization enables early blood–brain barrier disruption and long-term ischaemic reperfusion brain injury10.1038/ncomms105232041-1723https://doaj.org/article/47e5d60a78ef44e5b0ac4d3e29177a212016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10523https://doaj.org/toc/2041-1723Matrix metalloproteinases (MMPs) released from infiltrating immune cells are a major contributor to blood-brain barrier (BBB) breakdown following stroke. Here, the authors identify an early, MMP-independent BBB breakdown mechanism caused by rapid cytoskeletal rearrangements in endothelial cells, which could be inhibited by ADF.Yejie ShiLili ZhangHongjian PuLeilei MaoXiaoming HuXiaoyan JiangNa XuR. Anne StetlerFeng ZhangXiangrong LiuRehana K. LeakRichard F. KeepXunming JiJun ChenNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-18 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yejie Shi
Lili Zhang
Hongjian Pu
Leilei Mao
Xiaoming Hu
Xiaoyan Jiang
Na Xu
R. Anne Stetler
Feng Zhang
Xiangrong Liu
Rehana K. Leak
Richard F. Keep
Xunming Ji
Jun Chen
Rapid endothelial cytoskeletal reorganization enables early blood–brain barrier disruption and long-term ischaemic reperfusion brain injury
description Matrix metalloproteinases (MMPs) released from infiltrating immune cells are a major contributor to blood-brain barrier (BBB) breakdown following stroke. Here, the authors identify an early, MMP-independent BBB breakdown mechanism caused by rapid cytoskeletal rearrangements in endothelial cells, which could be inhibited by ADF.
format article
author Yejie Shi
Lili Zhang
Hongjian Pu
Leilei Mao
Xiaoming Hu
Xiaoyan Jiang
Na Xu
R. Anne Stetler
Feng Zhang
Xiangrong Liu
Rehana K. Leak
Richard F. Keep
Xunming Ji
Jun Chen
author_facet Yejie Shi
Lili Zhang
Hongjian Pu
Leilei Mao
Xiaoming Hu
Xiaoyan Jiang
Na Xu
R. Anne Stetler
Feng Zhang
Xiangrong Liu
Rehana K. Leak
Richard F. Keep
Xunming Ji
Jun Chen
author_sort Yejie Shi
title Rapid endothelial cytoskeletal reorganization enables early blood–brain barrier disruption and long-term ischaemic reperfusion brain injury
title_short Rapid endothelial cytoskeletal reorganization enables early blood–brain barrier disruption and long-term ischaemic reperfusion brain injury
title_full Rapid endothelial cytoskeletal reorganization enables early blood–brain barrier disruption and long-term ischaemic reperfusion brain injury
title_fullStr Rapid endothelial cytoskeletal reorganization enables early blood–brain barrier disruption and long-term ischaemic reperfusion brain injury
title_full_unstemmed Rapid endothelial cytoskeletal reorganization enables early blood–brain barrier disruption and long-term ischaemic reperfusion brain injury
title_sort rapid endothelial cytoskeletal reorganization enables early blood–brain barrier disruption and long-term ischaemic reperfusion brain injury
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/47e5d60a78ef44e5b0ac4d3e29177a21
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