Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5 −/− mice

RNF5 is a ubiquitin ligase regulating ER stress response. Here the authors show that Rnf5 deficiency potentiates immune response against melanoma via altered microbiota, and isolate bacterial strains that confer the same phenotype to wild type mice.

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Autores principales:	Yan Li, Roberto Tinoco, Lisa Elmén, Igor Segota, Yibo Xian, Yu Fujita, Avinash Sahu, Raphy Zarecki, Kerrie Marie, Yongmei Feng, Ali Khateb, Dennie T. Frederick, Shiri K. Ashkenazi, Hyungsoo Kim, Eva Guijarro Perez, Chi-Ping Day, Rafael S. Segura Muñoz, Robert Schmaltz, Shibu Yooseph, Miguel A. Tam, Tongwu Zhang, Emily Avitan-Hersh, Lihi Tzur, Shoshana Roizman, Ilanit Boyango, Gil Bar-Sela, Amir Orian, Randal J. Kaufman, Marcus Bosenberg, Colin R. Goding, Bas Baaten, Mitchell P. Levesque, Reinhard Dummer, Kevin Brown, Glenn Merlino, Eytan Ruppin, Keith Flaherty, Amanda Ramer-Tait, Tao Long, Scott N. Peterson, Linda M. Bradley, Ze’ev A. Ronai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/47e63127b17f4776963dab1e5a8faa8f
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spelling	oai:doaj.org-article:47e63127b17f4776963dab1e5a8faa8f2021-12-02T17:02:12ZGut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5 −/− mice10.1038/s41467-019-09525-y2041-1723https://doaj.org/article/47e63127b17f4776963dab1e5a8faa8f2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09525-yhttps://doaj.org/toc/2041-1723RNF5 is a ubiquitin ligase regulating ER stress response. Here the authors show that Rnf5 deficiency potentiates immune response against melanoma via altered microbiota, and isolate bacterial strains that confer the same phenotype to wild type mice.Yan LiRoberto TinocoLisa ElménIgor SegotaYibo XianYu FujitaAvinash SahuRaphy ZareckiKerrie MarieYongmei FengAli KhatebDennie T. FrederickShiri K. AshkenaziHyungsoo KimEva Guijarro PerezChi-Ping DayRafael S. Segura MuñozRobert SchmaltzShibu YoosephMiguel A. TamTongwu ZhangEmily Avitan-HershLihi TzurShoshana RoizmanIlanit BoyangoGil Bar-SelaAmir OrianRandal J. KaufmanMarcus BosenbergColin R. GodingBas BaatenMitchell P. LevesqueReinhard DummerKevin BrownGlenn MerlinoEytan RuppinKeith FlahertyAmanda Ramer-TaitTao LongScott N. PetersonLinda M. BradleyZe’ev A. RonaiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yan Li Roberto Tinoco Lisa Elmén Igor Segota Yibo Xian Yu Fujita Avinash Sahu Raphy Zarecki Kerrie Marie Yongmei Feng Ali Khateb Dennie T. Frederick Shiri K. Ashkenazi Hyungsoo Kim Eva Guijarro Perez Chi-Ping Day Rafael S. Segura Muñoz Robert Schmaltz Shibu Yooseph Miguel A. Tam Tongwu Zhang Emily Avitan-Hersh Lihi Tzur Shoshana Roizman Ilanit Boyango Gil Bar-Sela Amir Orian Randal J. Kaufman Marcus Bosenberg Colin R. Goding Bas Baaten Mitchell P. Levesque Reinhard Dummer Kevin Brown Glenn Merlino Eytan Ruppin Keith Flaherty Amanda Ramer-Tait Tao Long Scott N. Peterson Linda M. Bradley Ze’ev A. Ronai Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5 −/− mice
description	RNF5 is a ubiquitin ligase regulating ER stress response. Here the authors show that Rnf5 deficiency potentiates immune response against melanoma via altered microbiota, and isolate bacterial strains that confer the same phenotype to wild type mice.
format	article
author	Yan Li Roberto Tinoco Lisa Elmén Igor Segota Yibo Xian Yu Fujita Avinash Sahu Raphy Zarecki Kerrie Marie Yongmei Feng Ali Khateb Dennie T. Frederick Shiri K. Ashkenazi Hyungsoo Kim Eva Guijarro Perez Chi-Ping Day Rafael S. Segura Muñoz Robert Schmaltz Shibu Yooseph Miguel A. Tam Tongwu Zhang Emily Avitan-Hersh Lihi Tzur Shoshana Roizman Ilanit Boyango Gil Bar-Sela Amir Orian Randal J. Kaufman Marcus Bosenberg Colin R. Goding Bas Baaten Mitchell P. Levesque Reinhard Dummer Kevin Brown Glenn Merlino Eytan Ruppin Keith Flaherty Amanda Ramer-Tait Tao Long Scott N. Peterson Linda M. Bradley Ze’ev A. Ronai
author_facet	Yan Li Roberto Tinoco Lisa Elmén Igor Segota Yibo Xian Yu Fujita Avinash Sahu Raphy Zarecki Kerrie Marie Yongmei Feng Ali Khateb Dennie T. Frederick Shiri K. Ashkenazi Hyungsoo Kim Eva Guijarro Perez Chi-Ping Day Rafael S. Segura Muñoz Robert Schmaltz Shibu Yooseph Miguel A. Tam Tongwu Zhang Emily Avitan-Hersh Lihi Tzur Shoshana Roizman Ilanit Boyango Gil Bar-Sela Amir Orian Randal J. Kaufman Marcus Bosenberg Colin R. Goding Bas Baaten Mitchell P. Levesque Reinhard Dummer Kevin Brown Glenn Merlino Eytan Ruppin Keith Flaherty Amanda Ramer-Tait Tao Long Scott N. Peterson Linda M. Bradley Ze’ev A. Ronai
author_sort	Yan Li
title	Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5 −/− mice
title_short	Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5 −/− mice
title_full	Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5 −/− mice
title_fullStr	Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5 −/− mice
title_full_unstemmed	Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5 −/− mice
title_sort	gut microbiota dependent anti-tumor immunity restricts melanoma growth in rnf5 −/− mice
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/47e63127b17f4776963dab1e5a8faa8f
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Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5 −/− mice

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