Effects of Coffee Consumption on Insulin Resistance and Sensitivity: A Meta-Analysis
Coffee is widely consumed worldwide and impacts glucose metabolism. After a previous meta-analysis that evaluated the effects of coffee consumption on insulin resistance and sensitivity, additional randomized controlled trials (RCTs) were conducted. This meta-analysis aimed to evaluate the effects o...
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2021
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oai:doaj.org-article:47e81ab9ccae4c9dbe62e91f95c7c3c72021-11-25T18:35:44ZEffects of Coffee Consumption on Insulin Resistance and Sensitivity: A Meta-Analysis10.3390/nu131139762072-6643https://doaj.org/article/47e81ab9ccae4c9dbe62e91f95c7c3c72021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3976https://doaj.org/toc/2072-6643Coffee is widely consumed worldwide and impacts glucose metabolism. After a previous meta-analysis that evaluated the effects of coffee consumption on insulin resistance and sensitivity, additional randomized controlled trials (RCTs) were conducted. This meta-analysis aimed to evaluate the effects of coffee consumption on insulin resistance or sensitivity. We selected RCTs that evaluated the effects of coffee consumption for seven days or more on insulin sensitivity or resistance using surrogate indices (homeostasis model assessment for insulin resistance (HOMA-IR) and Matsuda index). The fixed-effects or random-effects model was used according to heterogeneity. Four studies with 268 participants were analyzed in this meta-analysis. Coffee consumption significantly decreased HOMA-IR compared to control (mean difference (MD) = −0.13; 95% CI = −0.24–−0.03; <i>p</i>-value = 0.01). However, the significance was not maintained in the sensitivity analysis (MD = −0.04; 95% CI = −0.18–0.10; <i>p</i>-value = 0.55) after excluding data from the healthy, young, normal-weight group. Matsuda index was not significantly different between coffee and control groups (standardized mean difference (SMD) = −0.33; 95% CI = −0.70–0.03; <i>p</i>-value = 0.08). In conclusion, long-term coffee consumption has a nonsignificant effect on insulin resistance and sensitivity. More studies evaluating the effects of coffee consumption in the healthy, young, and normal-weight individuals are needed.Su-Min MoonMin-Jin JooYoung-Seo LeeMyeong-Gyu KimMDPI AGarticlecoffeemeta-analysisinsulin resistanceinsulin sensitivityNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3976, p 3976 (2021) |
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coffee meta-analysis insulin resistance insulin sensitivity Nutrition. Foods and food supply TX341-641 |
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coffee meta-analysis insulin resistance insulin sensitivity Nutrition. Foods and food supply TX341-641 Su-Min Moon Min-Jin Joo Young-Seo Lee Myeong-Gyu Kim Effects of Coffee Consumption on Insulin Resistance and Sensitivity: A Meta-Analysis |
| description |
Coffee is widely consumed worldwide and impacts glucose metabolism. After a previous meta-analysis that evaluated the effects of coffee consumption on insulin resistance and sensitivity, additional randomized controlled trials (RCTs) were conducted. This meta-analysis aimed to evaluate the effects of coffee consumption on insulin resistance or sensitivity. We selected RCTs that evaluated the effects of coffee consumption for seven days or more on insulin sensitivity or resistance using surrogate indices (homeostasis model assessment for insulin resistance (HOMA-IR) and Matsuda index). The fixed-effects or random-effects model was used according to heterogeneity. Four studies with 268 participants were analyzed in this meta-analysis. Coffee consumption significantly decreased HOMA-IR compared to control (mean difference (MD) = −0.13; 95% CI = −0.24–−0.03; <i>p</i>-value = 0.01). However, the significance was not maintained in the sensitivity analysis (MD = −0.04; 95% CI = −0.18–0.10; <i>p</i>-value = 0.55) after excluding data from the healthy, young, normal-weight group. Matsuda index was not significantly different between coffee and control groups (standardized mean difference (SMD) = −0.33; 95% CI = −0.70–0.03; <i>p</i>-value = 0.08). In conclusion, long-term coffee consumption has a nonsignificant effect on insulin resistance and sensitivity. More studies evaluating the effects of coffee consumption in the healthy, young, and normal-weight individuals are needed. |
| format |
article |
| author |
Su-Min Moon Min-Jin Joo Young-Seo Lee Myeong-Gyu Kim |
| author_facet |
Su-Min Moon Min-Jin Joo Young-Seo Lee Myeong-Gyu Kim |
| author_sort |
Su-Min Moon |
| title |
Effects of Coffee Consumption on Insulin Resistance and Sensitivity: A Meta-Analysis |
| title_short |
Effects of Coffee Consumption on Insulin Resistance and Sensitivity: A Meta-Analysis |
| title_full |
Effects of Coffee Consumption on Insulin Resistance and Sensitivity: A Meta-Analysis |
| title_fullStr |
Effects of Coffee Consumption on Insulin Resistance and Sensitivity: A Meta-Analysis |
| title_full_unstemmed |
Effects of Coffee Consumption on Insulin Resistance and Sensitivity: A Meta-Analysis |
| title_sort |
effects of coffee consumption on insulin resistance and sensitivity: a meta-analysis |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/47e81ab9ccae4c9dbe62e91f95c7c3c7 |
| work_keys_str_mv |
AT suminmoon effectsofcoffeeconsumptiononinsulinresistanceandsensitivityametaanalysis AT minjinjoo effectsofcoffeeconsumptiononinsulinresistanceandsensitivityametaanalysis AT youngseolee effectsofcoffeeconsumptiononinsulinresistanceandsensitivityametaanalysis AT myeonggyukim effectsofcoffeeconsumptiononinsulinresistanceandsensitivityametaanalysis |
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1718410949244747776 |