Asymmetries of the arcuate fasciculus in monozygotic twins: genetic and nongenetic influences.

We assessed cerebral asymmetry for language in 35 monozygotic twin pairs. Using DTI, we reconstructed the arcuate fasciculus in each twin. Among the male twins, right-handed pairs showed greater left-sided asymmetry of connectivity in the arcuate fasciculus than did those with discordant handedness,...

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Autores principales:	Isabelle S Häberling, Gjurgjica Badzakova-Trajkov, Michael C Corballis
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/47e9868307b34ee49490658c1bfae023
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spelling	oai:doaj.org-article:47e9868307b34ee49490658c1bfae0232021-11-18T08:02:55ZAsymmetries of the arcuate fasciculus in monozygotic twins: genetic and nongenetic influences.1932-620310.1371/journal.pone.0052315https://doaj.org/article/47e9868307b34ee49490658c1bfae0232013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23300971/?tool=EBIhttps://doaj.org/toc/1932-6203We assessed cerebral asymmetry for language in 35 monozygotic twin pairs. Using DTI, we reconstructed the arcuate fasciculus in each twin. Among the male twins, right-handed pairs showed greater left-sided asymmetry of connectivity in the arcuate fasciculus than did those with discordant handedness, and within the discordant group the right-handers had greater left-sided volume asymmetry of the arcuate fasciculus than did their left-handed co-twins. There were no such effects in the female twins. Cerebral asymmetry for language showed more consistent results, with the more left-cerebrally dominant twins also showing more leftward asymmetry of high anisotropic fibers in the arcuate fasciculus, a result applying equally to female as to male twins. Reversals of arcuate fasciculus asymmetry were restricted to pairs discordant for language dominance, with the left-cerebrally dominant twins showing leftward and the right-cerebrally dominant twins rightward asymmetry of anisotropic diffusion in the arcuate fasciculus. Because monozygotic twin pairs share the same genotype, our results indicate a strong nongenetic component in arcuate fasciculus asymmetry, particularly in those discordant for cerebral asymmetry.Isabelle S HäberlingGjurgjica Badzakova-TrajkovMichael C CorballisPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 1, p e52315 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Isabelle S Häberling Gjurgjica Badzakova-Trajkov Michael C Corballis Asymmetries of the arcuate fasciculus in monozygotic twins: genetic and nongenetic influences.
description	We assessed cerebral asymmetry for language in 35 monozygotic twin pairs. Using DTI, we reconstructed the arcuate fasciculus in each twin. Among the male twins, right-handed pairs showed greater left-sided asymmetry of connectivity in the arcuate fasciculus than did those with discordant handedness, and within the discordant group the right-handers had greater left-sided volume asymmetry of the arcuate fasciculus than did their left-handed co-twins. There were no such effects in the female twins. Cerebral asymmetry for language showed more consistent results, with the more left-cerebrally dominant twins also showing more leftward asymmetry of high anisotropic fibers in the arcuate fasciculus, a result applying equally to female as to male twins. Reversals of arcuate fasciculus asymmetry were restricted to pairs discordant for language dominance, with the left-cerebrally dominant twins showing leftward and the right-cerebrally dominant twins rightward asymmetry of anisotropic diffusion in the arcuate fasciculus. Because monozygotic twin pairs share the same genotype, our results indicate a strong nongenetic component in arcuate fasciculus asymmetry, particularly in those discordant for cerebral asymmetry.
format	article
author	Isabelle S Häberling Gjurgjica Badzakova-Trajkov Michael C Corballis
author_facet	Isabelle S Häberling Gjurgjica Badzakova-Trajkov Michael C Corballis
author_sort	Isabelle S Häberling
title	Asymmetries of the arcuate fasciculus in monozygotic twins: genetic and nongenetic influences.
title_short	Asymmetries of the arcuate fasciculus in monozygotic twins: genetic and nongenetic influences.
title_full	Asymmetries of the arcuate fasciculus in monozygotic twins: genetic and nongenetic influences.
title_fullStr	Asymmetries of the arcuate fasciculus in monozygotic twins: genetic and nongenetic influences.
title_full_unstemmed	Asymmetries of the arcuate fasciculus in monozygotic twins: genetic and nongenetic influences.
title_sort	asymmetries of the arcuate fasciculus in monozygotic twins: genetic and nongenetic influences.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/47e9868307b34ee49490658c1bfae023
work_keys_str_mv	AT isabelleshaberling asymmetriesofthearcuatefasciculusinmonozygotictwinsgeneticandnongeneticinfluences AT gjurgjicabadzakovatrajkov asymmetriesofthearcuatefasciculusinmonozygotictwinsgeneticandnongeneticinfluences AT michaelccorballis asymmetriesofthearcuatefasciculusinmonozygotictwinsgeneticandnongeneticinfluences
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Asymmetries of the arcuate fasciculus in monozygotic twins: genetic and nongenetic influences.

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