Cardiomyocyte gene programs encoding morphological and functional signatures in cardiac hypertrophy and failure

Cardiomyocyte gene programs encoding morphological and functional signatures in cardiac hypertrophy and failure

The mechanisms underlying the transition from cardiac hypertrophy to heart failure following pressure overload are incompletely understood. Here the authors identify the gene programs encoding the morphological and functional characteristics of cardiomyocytes during the transition from early hypertr...

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Autores principales: Seitaro Nomura, Masahiro Satoh, Takanori Fujita, Tomoaki Higo, Tomokazu Sumida, Toshiyuki Ko, Toshihiro Yamaguchi, Takashige Tobita, Atsuhiko T. Naito, Masamichi Ito, Kanna Fujita, Mutsuo Harada, Haruhiro Toko, Yoshio Kobayashi, Kaoru Ito, Eiki Takimoto, Hiroshi Akazawa, Hiroyuki Morita, Hiroyuki Aburatani, Issei Komuro
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/47e9d418c4d04451afef93ddfe9403d2
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Sumario:The mechanisms underlying the transition from cardiac hypertrophy to heart failure following pressure overload are incompletely understood. Here the authors identify the gene programs encoding the morphological and functional characteristics of cardiomyocytes during the transition from early hypertrophy to heart failure via single-cell transcriptomics, establishing a key role for p53 signalling.

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