Cardiomyocyte gene programs encoding morphological and functional signatures in cardiac hypertrophy and failure

The mechanisms underlying the transition from cardiac hypertrophy to heart failure following pressure overload are incompletely understood. Here the authors identify the gene programs encoding the morphological and functional characteristics of cardiomyocytes during the transition from early hypertr...

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Autores principales:	Seitaro Nomura, Masahiro Satoh, Takanori Fujita, Tomoaki Higo, Tomokazu Sumida, Toshiyuki Ko, Toshihiro Yamaguchi, Takashige Tobita, Atsuhiko T. Naito, Masamichi Ito, Kanna Fujita, Mutsuo Harada, Haruhiro Toko, Yoshio Kobayashi, Kaoru Ito, Eiki Takimoto, Hiroshi Akazawa, Hiroyuki Morita, Hiroyuki Aburatani, Issei Komuro
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/47e9d418c4d04451afef93ddfe9403d2
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spelling	oai:doaj.org-article:47e9d418c4d04451afef93ddfe9403d22021-12-02T17:32:16ZCardiomyocyte gene programs encoding morphological and functional signatures in cardiac hypertrophy and failure10.1038/s41467-018-06639-72041-1723https://doaj.org/article/47e9d418c4d04451afef93ddfe9403d22018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06639-7https://doaj.org/toc/2041-1723The mechanisms underlying the transition from cardiac hypertrophy to heart failure following pressure overload are incompletely understood. Here the authors identify the gene programs encoding the morphological and functional characteristics of cardiomyocytes during the transition from early hypertrophy to heart failure via single-cell transcriptomics, establishing a key role for p53 signalling.Seitaro NomuraMasahiro SatohTakanori FujitaTomoaki HigoTomokazu SumidaToshiyuki KoToshihiro YamaguchiTakashige TobitaAtsuhiko T. NaitoMasamichi ItoKanna FujitaMutsuo HaradaHaruhiro TokoYoshio KobayashiKaoru ItoEiki TakimotoHiroshi AkazawaHiroyuki MoritaHiroyuki AburataniIssei KomuroNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Seitaro Nomura Masahiro Satoh Takanori Fujita Tomoaki Higo Tomokazu Sumida Toshiyuki Ko Toshihiro Yamaguchi Takashige Tobita Atsuhiko T. Naito Masamichi Ito Kanna Fujita Mutsuo Harada Haruhiro Toko Yoshio Kobayashi Kaoru Ito Eiki Takimoto Hiroshi Akazawa Hiroyuki Morita Hiroyuki Aburatani Issei Komuro Cardiomyocyte gene programs encoding morphological and functional signatures in cardiac hypertrophy and failure
description	The mechanisms underlying the transition from cardiac hypertrophy to heart failure following pressure overload are incompletely understood. Here the authors identify the gene programs encoding the morphological and functional characteristics of cardiomyocytes during the transition from early hypertrophy to heart failure via single-cell transcriptomics, establishing a key role for p53 signalling.
format	article
author	Seitaro Nomura Masahiro Satoh Takanori Fujita Tomoaki Higo Tomokazu Sumida Toshiyuki Ko Toshihiro Yamaguchi Takashige Tobita Atsuhiko T. Naito Masamichi Ito Kanna Fujita Mutsuo Harada Haruhiro Toko Yoshio Kobayashi Kaoru Ito Eiki Takimoto Hiroshi Akazawa Hiroyuki Morita Hiroyuki Aburatani Issei Komuro
author_facet	Seitaro Nomura Masahiro Satoh Takanori Fujita Tomoaki Higo Tomokazu Sumida Toshiyuki Ko Toshihiro Yamaguchi Takashige Tobita Atsuhiko T. Naito Masamichi Ito Kanna Fujita Mutsuo Harada Haruhiro Toko Yoshio Kobayashi Kaoru Ito Eiki Takimoto Hiroshi Akazawa Hiroyuki Morita Hiroyuki Aburatani Issei Komuro
author_sort	Seitaro Nomura
title	Cardiomyocyte gene programs encoding morphological and functional signatures in cardiac hypertrophy and failure
title_short	Cardiomyocyte gene programs encoding morphological and functional signatures in cardiac hypertrophy and failure
title_full	Cardiomyocyte gene programs encoding morphological and functional signatures in cardiac hypertrophy and failure
title_fullStr	Cardiomyocyte gene programs encoding morphological and functional signatures in cardiac hypertrophy and failure
title_full_unstemmed	Cardiomyocyte gene programs encoding morphological and functional signatures in cardiac hypertrophy and failure
title_sort	cardiomyocyte gene programs encoding morphological and functional signatures in cardiac hypertrophy and failure
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/47e9d418c4d04451afef93ddfe9403d2
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Cardiomyocyte gene programs encoding morphological and functional signatures in cardiac hypertrophy and failure

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