The Role Of Adiponectin, TNF-α And Glutathione In The Pathogenesis And Evolution Of Type 1 Diabetes

Csilla Enikő Szabo,1,2 Roxana Flavia Ilieș,3 Casian Simon Aioanei,3 Andreea Catana,3 Victoria Creț,2 Radu Sorin Șerban,1,2 Ioan Victor Pop3 1Department of Pediatrics I, Iuliu Hațieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania; 2Pediatric Clinic I, Pediatric Emergency Hospital, Cl...

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Autores principales:	Szabo CE, Ilieș RF, Aioanei CS, Catana A, Creț V, Șerban RS, Pop IV
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	adiponectin tnf-α glutathion pcr-rflp multiplex type 1 diabetes Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/47efec5f7ab54a439faa27d88aecf103
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spelling	oai:doaj.org-article:47efec5f7ab54a439faa27d88aecf1032021-12-02T04:58:19ZThe Role Of Adiponectin, TNF-α And Glutathione In The Pathogenesis And Evolution Of Type 1 Diabetes1178-7007https://doaj.org/article/47efec5f7ab54a439faa27d88aecf1032019-11-01T00:00:00Zhttps://www.dovepress.com/the-role-of-adiponectin-tnf-alpha-and-glutathione-in-the-pathogenesis--peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Csilla Enikő Szabo,1,2 Roxana Flavia Ilieș,3 Casian Simon Aioanei,3 Andreea Catana,3 Victoria Creț,2 Radu Sorin Șerban,1,2 Ioan Victor Pop3 1Department of Pediatrics I, Iuliu Hațieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania; 2Pediatric Clinic I, Pediatric Emergency Hospital, Cluj-Napoca, Romania; 3Department of Medical Genetics, Iuliu Hațieganu University of Medicine and Pharmacy, Cluj Napoca, RomaniaCorrespondence: Csilla Enikő SzaboDepartment of Pediatrics I, Iuliu Hațieganu University of Medicine and Pharmacy, Cluj-Napoca, RomaniaEmail szabocsillaeniko@gmail.comIntroduction: Type 1 diabetes (T1DM) is a chronic autoimmune or idiopathic condition, featuring complex and unique interactions between proteins and enzyme systems. The purpose of the present study is to investigate the role of AdipoQ +276G>T, TNF-α-308G>A, GSTT1/GSTM1 polymorphic variants in the development of T1DM.Materials and methods: The study is designed as a cross-sectional study, involving 72 diabetic cases and 90 controls. Genotyping was carried out according to specific protocols for the above-mentioned polymorphic variants.Results: The G allele of AdipoQ was associated with the development of type 1 diabetes (OR 0.577, CI95% 0.336–0.802, p=0.001), similar to the GG and GA genotypes (OR 0.405, CI95% 0.156–0.654, p=0.001 and OR 0.623, CI95% 0.401–0.855, p=0.004). The G allele of TNF-α was marginally associated with the development of type 1 diabetes (OR 0.789, CI95% 0.579–0.956, p=0.005). The presence of the T1 genotype was a strong predictor for type 1 diabetes (OR 3.4, CI95% 1.433–6.243, p<0.001).Conclusion: The results of our study suggest that G alleles of AdipoQ and TNFα act as a protective factor in T1DM, while the T1 allele for GST could be considered a risk factor for the development of Type 1 diabetes in our study group.Keywords: adiponectin, TNF-α, glutathion, pcr-rflp, multiplex, type 1 diabetesSzabo CEIlieș RFAioanei CSCatana ACreț VȘerban RSPop IVDove Medical Pressarticleadiponectintnf-αglutathionpcr-rflpmultiplextype 1 diabetesSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 12, Pp 2303-2308 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	adiponectin tnf-α glutathion pcr-rflp multiplex type 1 diabetes Specialties of internal medicine RC581-951
spellingShingle	adiponectin tnf-α glutathion pcr-rflp multiplex type 1 diabetes Specialties of internal medicine RC581-951 Szabo CE Ilieș RF Aioanei CS Catana A Creț V Șerban RS Pop IV The Role Of Adiponectin, TNF-α And Glutathione In The Pathogenesis And Evolution Of Type 1 Diabetes
description	Csilla Enikő Szabo,1,2 Roxana Flavia Ilieș,3 Casian Simon Aioanei,3 Andreea Catana,3 Victoria Creț,2 Radu Sorin Șerban,1,2 Ioan Victor Pop3 1Department of Pediatrics I, Iuliu Hațieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania; 2Pediatric Clinic I, Pediatric Emergency Hospital, Cluj-Napoca, Romania; 3Department of Medical Genetics, Iuliu Hațieganu University of Medicine and Pharmacy, Cluj Napoca, RomaniaCorrespondence: Csilla Enikő SzaboDepartment of Pediatrics I, Iuliu Hațieganu University of Medicine and Pharmacy, Cluj-Napoca, RomaniaEmail szabocsillaeniko@gmail.comIntroduction: Type 1 diabetes (T1DM) is a chronic autoimmune or idiopathic condition, featuring complex and unique interactions between proteins and enzyme systems. The purpose of the present study is to investigate the role of AdipoQ +276G>T, TNF-α-308G>A, GSTT1/GSTM1 polymorphic variants in the development of T1DM.Materials and methods: The study is designed as a cross-sectional study, involving 72 diabetic cases and 90 controls. Genotyping was carried out according to specific protocols for the above-mentioned polymorphic variants.Results: The G allele of AdipoQ was associated with the development of type 1 diabetes (OR 0.577, CI95% 0.336–0.802, p=0.001), similar to the GG and GA genotypes (OR 0.405, CI95% 0.156–0.654, p=0.001 and OR 0.623, CI95% 0.401–0.855, p=0.004). The G allele of TNF-α was marginally associated with the development of type 1 diabetes (OR 0.789, CI95% 0.579–0.956, p=0.005). The presence of the T1 genotype was a strong predictor for type 1 diabetes (OR 3.4, CI95% 1.433–6.243, p<0.001).Conclusion: The results of our study suggest that G alleles of AdipoQ and TNFα act as a protective factor in T1DM, while the T1 allele for GST could be considered a risk factor for the development of Type 1 diabetes in our study group.Keywords: adiponectin, TNF-α, glutathion, pcr-rflp, multiplex, type 1 diabetes
format	article
author	Szabo CE Ilieș RF Aioanei CS Catana A Creț V Șerban RS Pop IV
author_facet	Szabo CE Ilieș RF Aioanei CS Catana A Creț V Șerban RS Pop IV
author_sort	Szabo CE
title	The Role Of Adiponectin, TNF-α And Glutathione In The Pathogenesis And Evolution Of Type 1 Diabetes
title_short	The Role Of Adiponectin, TNF-α And Glutathione In The Pathogenesis And Evolution Of Type 1 Diabetes
title_full	The Role Of Adiponectin, TNF-α And Glutathione In The Pathogenesis And Evolution Of Type 1 Diabetes
title_fullStr	The Role Of Adiponectin, TNF-α And Glutathione In The Pathogenesis And Evolution Of Type 1 Diabetes
title_full_unstemmed	The Role Of Adiponectin, TNF-α And Glutathione In The Pathogenesis And Evolution Of Type 1 Diabetes
title_sort	role of adiponectin, tnf-α and glutathione in the pathogenesis and evolution of type 1 diabetes
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/47efec5f7ab54a439faa27d88aecf103
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The Role Of Adiponectin, TNF-α And Glutathione In The Pathogenesis And Evolution Of Type 1 Diabetes

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