tmem33 is essential for VEGF-mediated endothelial calcium oscillations and angiogenesis

Calcium signalling downstream of VEGF is essential for VEGF-induced angiogenesis. Here Savage et al. show that Transmembrane Protein 33 (TMEM33) is required for angiogenesis and the endothelial calcium response to VEGF, revealing a function for TMEM33 in multicellular organisms.

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Autores principales:	Aaron M. Savage, Sathishkumar Kurusamy, Yan Chen, Zhen Jiang, Karishma Chhabria, Ryan B. MacDonald, Hyejeong R. Kim, Heather L. Wilson, Fredericus J. M. van Eeden, Angel L. Armesilla, Timothy J. A. Chico, Robert N. Wilkinson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/47f0ef6f17ce4a149e51a23dc2a30f3c
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spelling	oai:doaj.org-article:47f0ef6f17ce4a149e51a23dc2a30f3c2021-12-02T14:38:44Ztmem33 is essential for VEGF-mediated endothelial calcium oscillations and angiogenesis10.1038/s41467-019-08590-72041-1723https://doaj.org/article/47f0ef6f17ce4a149e51a23dc2a30f3c2019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08590-7https://doaj.org/toc/2041-1723Calcium signalling downstream of VEGF is essential for VEGF-induced angiogenesis. Here Savage et al. show that Transmembrane Protein 33 (TMEM33) is required for angiogenesis and the endothelial calcium response to VEGF, revealing a function for TMEM33 in multicellular organisms.Aaron M. SavageSathishkumar KurusamyYan ChenZhen JiangKarishma ChhabriaRyan B. MacDonaldHyejeong R. KimHeather L. WilsonFredericus J. M. van EedenAngel L. ArmesillaTimothy J. A. ChicoRobert N. WilkinsonNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Aaron M. Savage Sathishkumar Kurusamy Yan Chen Zhen Jiang Karishma Chhabria Ryan B. MacDonald Hyejeong R. Kim Heather L. Wilson Fredericus J. M. van Eeden Angel L. Armesilla Timothy J. A. Chico Robert N. Wilkinson tmem33 is essential for VEGF-mediated endothelial calcium oscillations and angiogenesis
description	Calcium signalling downstream of VEGF is essential for VEGF-induced angiogenesis. Here Savage et al. show that Transmembrane Protein 33 (TMEM33) is required for angiogenesis and the endothelial calcium response to VEGF, revealing a function for TMEM33 in multicellular organisms.
format	article
author	Aaron M. Savage Sathishkumar Kurusamy Yan Chen Zhen Jiang Karishma Chhabria Ryan B. MacDonald Hyejeong R. Kim Heather L. Wilson Fredericus J. M. van Eeden Angel L. Armesilla Timothy J. A. Chico Robert N. Wilkinson
author_facet	Aaron M. Savage Sathishkumar Kurusamy Yan Chen Zhen Jiang Karishma Chhabria Ryan B. MacDonald Hyejeong R. Kim Heather L. Wilson Fredericus J. M. van Eeden Angel L. Armesilla Timothy J. A. Chico Robert N. Wilkinson
author_sort	Aaron M. Savage
title	tmem33 is essential for VEGF-mediated endothelial calcium oscillations and angiogenesis
title_short	tmem33 is essential for VEGF-mediated endothelial calcium oscillations and angiogenesis
title_full	tmem33 is essential for VEGF-mediated endothelial calcium oscillations and angiogenesis
title_fullStr	tmem33 is essential for VEGF-mediated endothelial calcium oscillations and angiogenesis
title_full_unstemmed	tmem33 is essential for VEGF-mediated endothelial calcium oscillations and angiogenesis
title_sort	tmem33 is essential for vegf-mediated endothelial calcium oscillations and angiogenesis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/47f0ef6f17ce4a149e51a23dc2a30f3c
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tmem33 is essential for VEGF-mediated endothelial calcium oscillations and angiogenesis

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