A recurrent point mutation in PRKCA is a hallmark of chordoid gliomas
Chordoid glioma is a slow growing diencephalic tumor whose mutational landscape is poorly characterized. Here, the authors perform whole-exome and RNA-sequencing and find that 15 of 16 chordoid glioma cases studied harbor the same PRKCA mutation which results in enhanced proliferation.
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2018
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oai:doaj.org-article:47f7d121d4304c4ca98cb2dbb0a6edde2021-12-02T16:49:38ZA recurrent point mutation in PRKCA is a hallmark of chordoid gliomas10.1038/s41467-018-04622-w2041-1723https://doaj.org/article/47f7d121d4304c4ca98cb2dbb0a6edde2018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04622-whttps://doaj.org/toc/2041-1723Chordoid glioma is a slow growing diencephalic tumor whose mutational landscape is poorly characterized. Here, the authors perform whole-exome and RNA-sequencing and find that 15 of 16 chordoid glioma cases studied harbor the same PRKCA mutation which results in enhanced proliferation.Shai RosenbergIva SimeonovaFranck BielleMaite VerreaultBertille BanceIsabelle Le RouxMailys DaniauArun NadaradjaneVincent GleizeSophie ParisYannick MarieMarine GiryMarc PolivkaDominique Figarella-BrangerMarie-Hélène Aubriot-LortonChiara VillaAlexandre VasiljevicEmmanuèle Lechapt-ZalcmanMichel KalamaridesAriane SharifKarima MokhtariStefano Maria PagnottaAntonio IavaroneAnna LasorellaEmmanuelle HuillardMarc SansonNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018) |
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EN |
| topic |
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| spellingShingle |
Science Q Shai Rosenberg Iva Simeonova Franck Bielle Maite Verreault Bertille Bance Isabelle Le Roux Mailys Daniau Arun Nadaradjane Vincent Gleize Sophie Paris Yannick Marie Marine Giry Marc Polivka Dominique Figarella-Branger Marie-Hélène Aubriot-Lorton Chiara Villa Alexandre Vasiljevic Emmanuèle Lechapt-Zalcman Michel Kalamarides Ariane Sharif Karima Mokhtari Stefano Maria Pagnotta Antonio Iavarone Anna Lasorella Emmanuelle Huillard Marc Sanson A recurrent point mutation in PRKCA is a hallmark of chordoid gliomas |
| description |
Chordoid glioma is a slow growing diencephalic tumor whose mutational landscape is poorly characterized. Here, the authors perform whole-exome and RNA-sequencing and find that 15 of 16 chordoid glioma cases studied harbor the same PRKCA mutation which results in enhanced proliferation. |
| format |
article |
| author |
Shai Rosenberg Iva Simeonova Franck Bielle Maite Verreault Bertille Bance Isabelle Le Roux Mailys Daniau Arun Nadaradjane Vincent Gleize Sophie Paris Yannick Marie Marine Giry Marc Polivka Dominique Figarella-Branger Marie-Hélène Aubriot-Lorton Chiara Villa Alexandre Vasiljevic Emmanuèle Lechapt-Zalcman Michel Kalamarides Ariane Sharif Karima Mokhtari Stefano Maria Pagnotta Antonio Iavarone Anna Lasorella Emmanuelle Huillard Marc Sanson |
| author_facet |
Shai Rosenberg Iva Simeonova Franck Bielle Maite Verreault Bertille Bance Isabelle Le Roux Mailys Daniau Arun Nadaradjane Vincent Gleize Sophie Paris Yannick Marie Marine Giry Marc Polivka Dominique Figarella-Branger Marie-Hélène Aubriot-Lorton Chiara Villa Alexandre Vasiljevic Emmanuèle Lechapt-Zalcman Michel Kalamarides Ariane Sharif Karima Mokhtari Stefano Maria Pagnotta Antonio Iavarone Anna Lasorella Emmanuelle Huillard Marc Sanson |
| author_sort |
Shai Rosenberg |
| title |
A recurrent point mutation in PRKCA is a hallmark of chordoid gliomas |
| title_short |
A recurrent point mutation in PRKCA is a hallmark of chordoid gliomas |
| title_full |
A recurrent point mutation in PRKCA is a hallmark of chordoid gliomas |
| title_fullStr |
A recurrent point mutation in PRKCA is a hallmark of chordoid gliomas |
| title_full_unstemmed |
A recurrent point mutation in PRKCA is a hallmark of chordoid gliomas |
| title_sort |
recurrent point mutation in prkca is a hallmark of chordoid gliomas |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/47f7d121d4304c4ca98cb2dbb0a6edde |
| work_keys_str_mv |
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