Association between tumor necrosis factor-α rs1800629 polymorphism and risk of asthma: a meta-analysis.

<h4>Objective</h4>The purpose of this study was to explore the association between the TNF-α rs1800629 (also refers as -308G/A) polymorphism and asthma susceptibility.<h4>Methods</h4>We searched the Pubmed, Embase, Cochrane Central Register of Controlled Trials (CENTRAL) and...

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Autores principales:	Guangdie Yang, Junjun Chen, Fei Xu, Zhang Bao, Yake Yao, Jianying Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/47f875432fae427daa9b009e99aae255
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spelling	oai:doaj.org-article:47f875432fae427daa9b009e99aae2552021-11-18T08:15:26ZAssociation between tumor necrosis factor-α rs1800629 polymorphism and risk of asthma: a meta-analysis.1932-620310.1371/journal.pone.0099962https://doaj.org/article/47f875432fae427daa9b009e99aae2552014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24936650/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>The purpose of this study was to explore the association between the TNF-α rs1800629 (also refers as -308G/A) polymorphism and asthma susceptibility.<h4>Methods</h4>We searched the Pubmed, Embase, Cochrane Central Register of Controlled Trials (CENTRAL) and Wanfang databases. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to calculate the strength of association.<h4>Results</h4>A total of 34 studies involving 5477 asthma patients and 5962 controls were included in present study. The results indicated that TNF-α rs1800629 polymorphism was significantly associated with asthma risk in a recessive genetic model (OR = 1.46, 95% CI 1.21-1.76, P<0.0001). Subgroup analyses found that the TNF-α rs1800629 polymorphism was significantly associated with asthma risk in West Asians and South Asians (OR = 2.47, 95% CI = 1.48-4.12, P = 0.0005; OR = 1.83, 95% CI = 1.42-2.36, P<0.00001), but not East Asians and Caucasians. Furthermore, significant association also was observed in allergic asthma (OR = 1.51, 95% CI = 1.24-1.83, P<0.0001), adults and children (OR = 1.43, 95 CI% = 1.07-1.91, P = 0.02; OR = 1.57, 95% CI = 1.19-2.06, P = 0.001).<h4>Conclusions</h4>This meta-analysis suggested that the rs1800629 polymorphism in TNF-α was a risk factor for asthma.Guangdie YangJunjun ChenFei XuZhang BaoYake YaoJianying ZhouPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 6, p e99962 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Guangdie Yang Junjun Chen Fei Xu Zhang Bao Yake Yao Jianying Zhou Association between tumor necrosis factor-α rs1800629 polymorphism and risk of asthma: a meta-analysis.
description	<h4>Objective</h4>The purpose of this study was to explore the association between the TNF-α rs1800629 (also refers as -308G/A) polymorphism and asthma susceptibility.<h4>Methods</h4>We searched the Pubmed, Embase, Cochrane Central Register of Controlled Trials (CENTRAL) and Wanfang databases. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to calculate the strength of association.<h4>Results</h4>A total of 34 studies involving 5477 asthma patients and 5962 controls were included in present study. The results indicated that TNF-α rs1800629 polymorphism was significantly associated with asthma risk in a recessive genetic model (OR = 1.46, 95% CI 1.21-1.76, P<0.0001). Subgroup analyses found that the TNF-α rs1800629 polymorphism was significantly associated with asthma risk in West Asians and South Asians (OR = 2.47, 95% CI = 1.48-4.12, P = 0.0005; OR = 1.83, 95% CI = 1.42-2.36, P<0.00001), but not East Asians and Caucasians. Furthermore, significant association also was observed in allergic asthma (OR = 1.51, 95% CI = 1.24-1.83, P<0.0001), adults and children (OR = 1.43, 95 CI% = 1.07-1.91, P = 0.02; OR = 1.57, 95% CI = 1.19-2.06, P = 0.001).<h4>Conclusions</h4>This meta-analysis suggested that the rs1800629 polymorphism in TNF-α was a risk factor for asthma.
format	article
author	Guangdie Yang Junjun Chen Fei Xu Zhang Bao Yake Yao Jianying Zhou
author_facet	Guangdie Yang Junjun Chen Fei Xu Zhang Bao Yake Yao Jianying Zhou
author_sort	Guangdie Yang
title	Association between tumor necrosis factor-α rs1800629 polymorphism and risk of asthma: a meta-analysis.
title_short	Association between tumor necrosis factor-α rs1800629 polymorphism and risk of asthma: a meta-analysis.
title_full	Association between tumor necrosis factor-α rs1800629 polymorphism and risk of asthma: a meta-analysis.
title_fullStr	Association between tumor necrosis factor-α rs1800629 polymorphism and risk of asthma: a meta-analysis.
title_full_unstemmed	Association between tumor necrosis factor-α rs1800629 polymorphism and risk of asthma: a meta-analysis.
title_sort	association between tumor necrosis factor-α rs1800629 polymorphism and risk of asthma: a meta-analysis.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/47f875432fae427daa9b009e99aae255
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Association between tumor necrosis factor-α rs1800629 polymorphism and risk of asthma: a meta-analysis.

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