Deducing the presence of proteins and proteoforms in quantitative proteomics

An accurate quantitation of different proteoforms remains challenging due to incomplete protein sequence coverage in mass spectrometry datasets. Here the authors describe a method to facilitate the discovery of proteoforms that may otherwise not be considered due to incomplete protein coverage or am...

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Autores principales:	Casimir Bamberger, Salvador Martínez-Bartolomé, Miranda Montgomery, Sandra Pankow, John D. Hulleman, Jeffery W. Kelly, John R. Yates
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/47f96cf6a5c54801b5fbbaa897a69399
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spelling	oai:doaj.org-article:47f96cf6a5c54801b5fbbaa897a693992021-12-02T17:31:29ZDeducing the presence of proteins and proteoforms in quantitative proteomics10.1038/s41467-018-04411-52041-1723https://doaj.org/article/47f96cf6a5c54801b5fbbaa897a693992018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04411-5https://doaj.org/toc/2041-1723An accurate quantitation of different proteoforms remains challenging due to incomplete protein sequence coverage in mass spectrometry datasets. Here the authors describe a method to facilitate the discovery of proteoforms that may otherwise not be considered due to incomplete protein coverage or ambiguities in mapping peptides back to proteins.Casimir BambergerSalvador Martínez-BartoloméMiranda MontgomerySandra PankowJohn D. HullemanJeffery W. KellyJohn R. YatesNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Casimir Bamberger Salvador Martínez-Bartolomé Miranda Montgomery Sandra Pankow John D. Hulleman Jeffery W. Kelly John R. Yates Deducing the presence of proteins and proteoforms in quantitative proteomics
description	An accurate quantitation of different proteoforms remains challenging due to incomplete protein sequence coverage in mass spectrometry datasets. Here the authors describe a method to facilitate the discovery of proteoforms that may otherwise not be considered due to incomplete protein coverage or ambiguities in mapping peptides back to proteins.
format	article
author	Casimir Bamberger Salvador Martínez-Bartolomé Miranda Montgomery Sandra Pankow John D. Hulleman Jeffery W. Kelly John R. Yates
author_facet	Casimir Bamberger Salvador Martínez-Bartolomé Miranda Montgomery Sandra Pankow John D. Hulleman Jeffery W. Kelly John R. Yates
author_sort	Casimir Bamberger
title	Deducing the presence of proteins and proteoforms in quantitative proteomics
title_short	Deducing the presence of proteins and proteoforms in quantitative proteomics
title_full	Deducing the presence of proteins and proteoforms in quantitative proteomics
title_fullStr	Deducing the presence of proteins and proteoforms in quantitative proteomics
title_full_unstemmed	Deducing the presence of proteins and proteoforms in quantitative proteomics
title_sort	deducing the presence of proteins and proteoforms in quantitative proteomics
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/47f96cf6a5c54801b5fbbaa897a69399
work_keys_str_mv	AT casimirbamberger deducingthepresenceofproteinsandproteoformsinquantitativeproteomics AT salvadormartinezbartolome deducingthepresenceofproteinsandproteoformsinquantitativeproteomics AT mirandamontgomery deducingthepresenceofproteinsandproteoformsinquantitativeproteomics AT sandrapankow deducingthepresenceofproteinsandproteoformsinquantitativeproteomics AT johndhulleman deducingthepresenceofproteinsandproteoformsinquantitativeproteomics AT jefferywkelly deducingthepresenceofproteinsandproteoformsinquantitativeproteomics AT johnryates deducingthepresenceofproteinsandproteoformsinquantitativeproteomics
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Deducing the presence of proteins and proteoforms in quantitative proteomics

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