Genetic signatures for enhanced olfaction in the African mole-rats.

The Olfactory Receptor (OR) superfamily, the largest in the vertebrate genome, is responsible for vertebrate olfaction and is traditionally subdivided into 17 OR families. Recent studies characterising whole-OR subgenomes revealed a 'birth and death' model of evolution for a range of speci...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sofia Stathopoulos, Jacqueline M Bishop, Colleen O'Ryan
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/47fa9f37d62a4fe7af8093dd62fc460f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:47fa9f37d62a4fe7af8093dd62fc460f
record_format	dspace
spelling	oai:doaj.org-article:47fa9f37d62a4fe7af8093dd62fc460f2021-11-18T08:25:07ZGenetic signatures for enhanced olfaction in the African mole-rats.1932-620310.1371/journal.pone.0093336https://doaj.org/article/47fa9f37d62a4fe7af8093dd62fc460f2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24699281/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203The Olfactory Receptor (OR) superfamily, the largest in the vertebrate genome, is responsible for vertebrate olfaction and is traditionally subdivided into 17 OR families. Recent studies characterising whole-OR subgenomes revealed a 'birth and death' model of evolution for a range of species, however little is known about fine-scale evolutionary dynamics within single-OR families. This study reports the first assessment of fine-scale OR evolution and variation in African mole-rats (Bathyergidae), a family of subterranean rodents endemic to sub-Saharan Africa. Because of the selective pressures of life underground, enhanced olfaction is proposed to be fundamental to the evolutionary success of the Bathyergidae, resulting in a highly diversified OR gene-repertoire. Using a PCR-sequencing approach, we analysed variation in the OR7 family across 14 extant bathyergid species, which revealed enhanced levels of functional polymorphisms concentrated across the receptors' ligand-binding region. We propose that mole-rats are able to recognise a broad range of odorants and that this diversity is reflected throughout their OR7 gene repertoire. Using both classic tests and tree-based methods to test for signals of selection, we investigate evolutionary forces across the mole-rat OR7 gene tree. Four well-supported clades emerged in the OR phylogeny, with varying signals of selection; from neutrality to positive and purifying selection. Bathyergid life-history traits and environmental niche-specialisation are explored as possible drivers of adaptive OR evolution, emerging as non-exclusive contributors to the positive selection observed at OR7 genes. Our results reveal unexpected complexity of evolutionary mechanisms acting within a single OR family, providing insightful perspectives into OR evolutionary dynamics.Sofia StathopoulosJacqueline M BishopColleen O'RyanPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 4, p e93336 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sofia Stathopoulos Jacqueline M Bishop Colleen O'Ryan Genetic signatures for enhanced olfaction in the African mole-rats.
description	The Olfactory Receptor (OR) superfamily, the largest in the vertebrate genome, is responsible for vertebrate olfaction and is traditionally subdivided into 17 OR families. Recent studies characterising whole-OR subgenomes revealed a 'birth and death' model of evolution for a range of species, however little is known about fine-scale evolutionary dynamics within single-OR families. This study reports the first assessment of fine-scale OR evolution and variation in African mole-rats (Bathyergidae), a family of subterranean rodents endemic to sub-Saharan Africa. Because of the selective pressures of life underground, enhanced olfaction is proposed to be fundamental to the evolutionary success of the Bathyergidae, resulting in a highly diversified OR gene-repertoire. Using a PCR-sequencing approach, we analysed variation in the OR7 family across 14 extant bathyergid species, which revealed enhanced levels of functional polymorphisms concentrated across the receptors' ligand-binding region. We propose that mole-rats are able to recognise a broad range of odorants and that this diversity is reflected throughout their OR7 gene repertoire. Using both classic tests and tree-based methods to test for signals of selection, we investigate evolutionary forces across the mole-rat OR7 gene tree. Four well-supported clades emerged in the OR phylogeny, with varying signals of selection; from neutrality to positive and purifying selection. Bathyergid life-history traits and environmental niche-specialisation are explored as possible drivers of adaptive OR evolution, emerging as non-exclusive contributors to the positive selection observed at OR7 genes. Our results reveal unexpected complexity of evolutionary mechanisms acting within a single OR family, providing insightful perspectives into OR evolutionary dynamics.
format	article
author	Sofia Stathopoulos Jacqueline M Bishop Colleen O'Ryan
author_facet	Sofia Stathopoulos Jacqueline M Bishop Colleen O'Ryan
author_sort	Sofia Stathopoulos
title	Genetic signatures for enhanced olfaction in the African mole-rats.
title_short	Genetic signatures for enhanced olfaction in the African mole-rats.
title_full	Genetic signatures for enhanced olfaction in the African mole-rats.
title_fullStr	Genetic signatures for enhanced olfaction in the African mole-rats.
title_full_unstemmed	Genetic signatures for enhanced olfaction in the African mole-rats.
title_sort	genetic signatures for enhanced olfaction in the african mole-rats.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/47fa9f37d62a4fe7af8093dd62fc460f
work_keys_str_mv	AT sofiastathopoulos geneticsignaturesforenhancedolfactionintheafricanmolerats AT jacquelinembishop geneticsignaturesforenhancedolfactionintheafricanmolerats AT colleenoryan geneticsignaturesforenhancedolfactionintheafricanmolerats
_version_	1718421798644613120

Genetic signatures for enhanced olfaction in the African mole-rats.

Ejemplares similares