Morphological variables associated with ruptured basilar tip aneurysms

Abstract Morphological factors of intracranial aneurysms and the surrounding vasculature could affect aneurysm rupture risk in a location specific manner. Our goal was to identify image-based morphological parameters that correlated with ruptured basilar tip aneurysms. Three-dimensional morphologica...

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Autores principales:	Jian Zhang, Anil Can, Pui Man Rosalind Lai, Srinivasan Mukundan, Victor M. Castro, Dmitriy Dligach, Sean Finan, Vivian S. Gainer, Nancy A. Shadick, Guergana Savova, Shawn N. Murphy, Tianxi Cai, Scott T. Weiss, Rose Du
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/47fc2061ff114857bd023f840f264691
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spelling	oai:doaj.org-article:47fc2061ff114857bd023f840f2646912021-12-02T13:23:50ZMorphological variables associated with ruptured basilar tip aneurysms10.1038/s41598-021-81364-82045-2322https://doaj.org/article/47fc2061ff114857bd023f840f2646912021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81364-8https://doaj.org/toc/2045-2322Abstract Morphological factors of intracranial aneurysms and the surrounding vasculature could affect aneurysm rupture risk in a location specific manner. Our goal was to identify image-based morphological parameters that correlated with ruptured basilar tip aneurysms. Three-dimensional morphological parameters obtained from CT-angiography (CTA) or digital subtraction angiography (DSA) from 200 patients with basilar tip aneurysms diagnosed at the Brigham and Women’s Hospital and Massachusetts General Hospital between 1990 and 2016 were evaluated. We examined aneurysm wall irregularity, the presence of daughter domes, hypoplastic, aplastic or fetal PCoAs, vertebral dominance, maximum height, perpendicular height, width, neck diameter, aspect and size ratio, height/width ratio, and diameters and angles of surrounding parent and daughter vessels. Univariable and multivariable statistical analyses were performed to determine statistical significance. In multivariable analysis, presence of a daughter dome, aspect ratio, and larger flow angle were significantly associated with rupture status. We also introduced two new variables, diameter size ratio and parent-daughter angle ratio, which were both significantly inversely associated with ruptured basilar tip aneurysms. Notably, multivariable analyses also showed that larger diameter size ratio was associated with higher Hunt-Hess score while smaller flow angle was associated with higher Fisher grade. These easily measurable parameters, including a new parameter that is unlikely to be affected by the formation of the aneurysm, could aid in screening strategies in high-risk patients with basilar tip aneurysms. One should note, however, that the changes in parameters related to aneurysm morphology may be secondary to aneurysm rupture rather than causal.Jian ZhangAnil CanPui Man Rosalind LaiSrinivasan MukundanVictor M. CastroDmitriy DligachSean FinanVivian S. GainerNancy A. ShadickGuergana SavovaShawn N. MurphyTianxi CaiScott T. WeissRose DuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jian Zhang Anil Can Pui Man Rosalind Lai Srinivasan Mukundan Victor M. Castro Dmitriy Dligach Sean Finan Vivian S. Gainer Nancy A. Shadick Guergana Savova Shawn N. Murphy Tianxi Cai Scott T. Weiss Rose Du Morphological variables associated with ruptured basilar tip aneurysms
description	Abstract Morphological factors of intracranial aneurysms and the surrounding vasculature could affect aneurysm rupture risk in a location specific manner. Our goal was to identify image-based morphological parameters that correlated with ruptured basilar tip aneurysms. Three-dimensional morphological parameters obtained from CT-angiography (CTA) or digital subtraction angiography (DSA) from 200 patients with basilar tip aneurysms diagnosed at the Brigham and Women’s Hospital and Massachusetts General Hospital between 1990 and 2016 were evaluated. We examined aneurysm wall irregularity, the presence of daughter domes, hypoplastic, aplastic or fetal PCoAs, vertebral dominance, maximum height, perpendicular height, width, neck diameter, aspect and size ratio, height/width ratio, and diameters and angles of surrounding parent and daughter vessels. Univariable and multivariable statistical analyses were performed to determine statistical significance. In multivariable analysis, presence of a daughter dome, aspect ratio, and larger flow angle were significantly associated with rupture status. We also introduced two new variables, diameter size ratio and parent-daughter angle ratio, which were both significantly inversely associated with ruptured basilar tip aneurysms. Notably, multivariable analyses also showed that larger diameter size ratio was associated with higher Hunt-Hess score while smaller flow angle was associated with higher Fisher grade. These easily measurable parameters, including a new parameter that is unlikely to be affected by the formation of the aneurysm, could aid in screening strategies in high-risk patients with basilar tip aneurysms. One should note, however, that the changes in parameters related to aneurysm morphology may be secondary to aneurysm rupture rather than causal.
format	article
author	Jian Zhang Anil Can Pui Man Rosalind Lai Srinivasan Mukundan Victor M. Castro Dmitriy Dligach Sean Finan Vivian S. Gainer Nancy A. Shadick Guergana Savova Shawn N. Murphy Tianxi Cai Scott T. Weiss Rose Du
author_facet	Jian Zhang Anil Can Pui Man Rosalind Lai Srinivasan Mukundan Victor M. Castro Dmitriy Dligach Sean Finan Vivian S. Gainer Nancy A. Shadick Guergana Savova Shawn N. Murphy Tianxi Cai Scott T. Weiss Rose Du
author_sort	Jian Zhang
title	Morphological variables associated with ruptured basilar tip aneurysms
title_short	Morphological variables associated with ruptured basilar tip aneurysms
title_full	Morphological variables associated with ruptured basilar tip aneurysms
title_fullStr	Morphological variables associated with ruptured basilar tip aneurysms
title_full_unstemmed	Morphological variables associated with ruptured basilar tip aneurysms
title_sort	morphological variables associated with ruptured basilar tip aneurysms
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/47fc2061ff114857bd023f840f264691
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Morphological variables associated with ruptured basilar tip aneurysms

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