Imbalanced Dermic Microbiome Aggravates Inflammation in Toenail Paronychia

The commensal microbiome influences skin immunity, but its function in toenail health remains unclear. Paronychia is one of the most common inflammatory toenail diseases, but antibiotic treatment is seldom effective in clinical cases. In this study, we performed 16S rRNA sequencing to investigate th...

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Autores principales:	Ying Li, Han Ma, Liang Xue, Huizhen Chen, Rui Pang, Yanyan Shang, Juan Luo, Xinqiang Xie, Jumei Zhang, Yu Ding, Moutong Chen, Juan Wang, Qingping Wu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	dermis microbiome paronychia inflammation anaerobic microbes Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/47fefc17f6e74b25bfa82d28ca5eb1bc
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spelling	oai:doaj.org-article:47fefc17f6e74b25bfa82d28ca5eb1bc2021-12-03T04:44:45ZImbalanced Dermic Microbiome Aggravates Inflammation in Toenail Paronychia2235-298810.3389/fcimb.2021.781927https://doaj.org/article/47fefc17f6e74b25bfa82d28ca5eb1bc2021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcimb.2021.781927/fullhttps://doaj.org/toc/2235-2988The commensal microbiome influences skin immunity, but its function in toenail health remains unclear. Paronychia is one of the most common inflammatory toenail diseases, but antibiotic treatment is seldom effective in clinical cases. In this study, we performed 16S rRNA sequencing to investigate the characteristics of microbes associated with paronychia in order to identify the key microorganisms involved in inflammation. Seventy dermic samples were collected from patients with paronychia and the differences in dermic microbiota were analyzed in patients with different inflammation severities. Distinct clustering of dermal microbiota was observed in the dermis with different inflammation severities. A higher relative abundance of anaerobic microorganisms such as Parvimona, Prevotella, and Peptoniphilus was observed in severe paronychia, whereas Lactobacillus disappeared with disease progression. Co-occurring network analysis suggested that the disturbance of the dermic microbiome and attenuation of antagonism by Lactobacillus against anaerobic pathogens may aggravate inflammation in paronychia. Functional analysis showed that dermic microbiome disturbance may worsen microbial metabolism and tissue repair in the skin. In conclusion, we revealed that an increased abundance of anaerobic microorganisms and loss of Lactobacillus in the dermis may promote paronychia progression and microbiological imbalance may aggravate inflammation in patients with paronychia.Ying LiHan MaLiang XueHuizhen ChenHuizhen ChenRui PangYanyan ShangYanyan ShangJuan LuoXinqiang XieJumei ZhangYu DingMoutong ChenJuan WangQingping WuFrontiers Media S.A.articledermismicrobiomeparonychiainflammationanaerobic microbesMicrobiologyQR1-502ENFrontiers in Cellular and Infection Microbiology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	dermis microbiome paronychia inflammation anaerobic microbes Microbiology QR1-502
spellingShingle	dermis microbiome paronychia inflammation anaerobic microbes Microbiology QR1-502 Ying Li Han Ma Liang Xue Huizhen Chen Huizhen Chen Rui Pang Yanyan Shang Yanyan Shang Juan Luo Xinqiang Xie Jumei Zhang Yu Ding Moutong Chen Juan Wang Qingping Wu Imbalanced Dermic Microbiome Aggravates Inflammation in Toenail Paronychia
description	The commensal microbiome influences skin immunity, but its function in toenail health remains unclear. Paronychia is one of the most common inflammatory toenail diseases, but antibiotic treatment is seldom effective in clinical cases. In this study, we performed 16S rRNA sequencing to investigate the characteristics of microbes associated with paronychia in order to identify the key microorganisms involved in inflammation. Seventy dermic samples were collected from patients with paronychia and the differences in dermic microbiota were analyzed in patients with different inflammation severities. Distinct clustering of dermal microbiota was observed in the dermis with different inflammation severities. A higher relative abundance of anaerobic microorganisms such as Parvimona, Prevotella, and Peptoniphilus was observed in severe paronychia, whereas Lactobacillus disappeared with disease progression. Co-occurring network analysis suggested that the disturbance of the dermic microbiome and attenuation of antagonism by Lactobacillus against anaerobic pathogens may aggravate inflammation in paronychia. Functional analysis showed that dermic microbiome disturbance may worsen microbial metabolism and tissue repair in the skin. In conclusion, we revealed that an increased abundance of anaerobic microorganisms and loss of Lactobacillus in the dermis may promote paronychia progression and microbiological imbalance may aggravate inflammation in patients with paronychia.
format	article
author	Ying Li Han Ma Liang Xue Huizhen Chen Huizhen Chen Rui Pang Yanyan Shang Yanyan Shang Juan Luo Xinqiang Xie Jumei Zhang Yu Ding Moutong Chen Juan Wang Qingping Wu
author_facet	Ying Li Han Ma Liang Xue Huizhen Chen Huizhen Chen Rui Pang Yanyan Shang Yanyan Shang Juan Luo Xinqiang Xie Jumei Zhang Yu Ding Moutong Chen Juan Wang Qingping Wu
author_sort	Ying Li
title	Imbalanced Dermic Microbiome Aggravates Inflammation in Toenail Paronychia
title_short	Imbalanced Dermic Microbiome Aggravates Inflammation in Toenail Paronychia
title_full	Imbalanced Dermic Microbiome Aggravates Inflammation in Toenail Paronychia
title_fullStr	Imbalanced Dermic Microbiome Aggravates Inflammation in Toenail Paronychia
title_full_unstemmed	Imbalanced Dermic Microbiome Aggravates Inflammation in Toenail Paronychia
title_sort	imbalanced dermic microbiome aggravates inflammation in toenail paronychia
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/47fefc17f6e74b25bfa82d28ca5eb1bc
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Imbalanced Dermic Microbiome Aggravates Inflammation in Toenail Paronychia

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