Effects of a leucine and pyridoxine-containing nutraceutical on body weight and composition in obese subjects

Effects of a leucine and pyridoxine-containing nutraceutical on body weight and composition in obese subjects

Michael B Zemel,1,2 Antje Bruckbauer11NuSirt Sciences Inc, 2Nutrition Department, The University of Tennessee, Knoxville, TN, USABackground: We recently demonstrated leucine to modulate energy partitioning between adipose tissue and muscle. Further, leucine exhibits a synergy with B6, resulting in r...

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Autores principales: Zemel MB, Bruckbauer A
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2013
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Specialties of internal medicine
RC581-951
Acceso en línea:https://doaj.org/article/4801ab0558e749e9bbe0dbd8cf629f51
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spelling oai:doaj.org-article:4801ab0558e749e9bbe0dbd8cf629f512021-12-02T06:03:36ZEffects of a leucine and pyridoxine-containing nutraceutical on body weight and composition in obese subjects1178-7007https://doaj.org/article/4801ab0558e749e9bbe0dbd8cf629f512013-08-01T00:00:00Zhttp://www.dovepress.com/effects-of-a-leucine-and-pyridoxine-containing-nutraceutical-on-body-w-a14147https://doaj.org/toc/1178-7007Michael B Zemel,1,2 Antje Bruckbauer11NuSirt Sciences Inc, 2Nutrition Department, The University of Tennessee, Knoxville, TN, USABackground: We recently demonstrated leucine to modulate energy partitioning between adipose tissue and muscle. Further, leucine exhibits a synergy with B6, resulting in reduced adipocyte lipid storage coupled with increased muscle fat oxidation. Accordingly, a nutraceutical (NuShape&trade;) containing 2.25 g leucine and 30 mg B6 increased fat oxidation by > 30 g/day in a 28-day randomized controlled trial. The present study evaluated the long-term efficacy of this combination in modulating body weight and composition.Methods: Two 24-week, placebo-controlled, randomized trials, one with weight maintenance (n = 20) and one hypocaloric (-500 kcal/day; n = 24), were conducted using the nutraceutical Nushape in obese subjects.Results: The supplement resulted in fat loss in the maintenance study (-1.12 &plusmn; 0.36 and -1.82 &plusmn; 0.70 kg at 12 and 24 weeks, P < 0.01 versus placebo) while no change was found in the placebo group. In the hypocaloric study, the supplement group lost up to twice as much weight (6.18 &plusmn; 1.02 versus 3.40 &plusmn; 0.81 kg at 12 weeks and 8.15 &plusmn; 1.33 versus 5.25 &plusmn; 1.13 kg at 24 weeks, P < 0.01) and fat (4.96 &plusmn; 0.61 versus 2.31 &plusmn; 0.53 kg at 12 weeks and 7.00 &plusmn; 0.95 versus 4.22 &plusmn; 0.74 kg at 24 weeks, P < 0.01) than the placebo group.Conclusion: This nutraceutical combination results in significant fat loss in the absence of caloric restriction and markedly enhances weight and fat loss by 50%&ndash;80% over a 24-week period.Keywords: leucine, vitamin B6, pyridoxine, fat loss, weight loss, caloric restriction, adiposity, body compositionZemel MBBruckbauer ADove Medical PressarticleSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol 2013, Iss default, Pp 309-315 (2013)
institution DOAJ
collection DOAJ
language EN
topic Specialties of internal medicine
RC581-951
spellingShingle Specialties of internal medicine
RC581-951
Zemel MB
Bruckbauer A
Effects of a leucine and pyridoxine-containing nutraceutical on body weight and composition in obese subjects
description Michael B Zemel,1,2 Antje Bruckbauer11NuSirt Sciences Inc, 2Nutrition Department, The University of Tennessee, Knoxville, TN, USABackground: We recently demonstrated leucine to modulate energy partitioning between adipose tissue and muscle. Further, leucine exhibits a synergy with B6, resulting in reduced adipocyte lipid storage coupled with increased muscle fat oxidation. Accordingly, a nutraceutical (NuShape&trade;) containing 2.25 g leucine and 30 mg B6 increased fat oxidation by > 30 g/day in a 28-day randomized controlled trial. The present study evaluated the long-term efficacy of this combination in modulating body weight and composition.Methods: Two 24-week, placebo-controlled, randomized trials, one with weight maintenance (n = 20) and one hypocaloric (-500 kcal/day; n = 24), were conducted using the nutraceutical Nushape in obese subjects.Results: The supplement resulted in fat loss in the maintenance study (-1.12 &plusmn; 0.36 and -1.82 &plusmn; 0.70 kg at 12 and 24 weeks, P < 0.01 versus placebo) while no change was found in the placebo group. In the hypocaloric study, the supplement group lost up to twice as much weight (6.18 &plusmn; 1.02 versus 3.40 &plusmn; 0.81 kg at 12 weeks and 8.15 &plusmn; 1.33 versus 5.25 &plusmn; 1.13 kg at 24 weeks, P < 0.01) and fat (4.96 &plusmn; 0.61 versus 2.31 &plusmn; 0.53 kg at 12 weeks and 7.00 &plusmn; 0.95 versus 4.22 &plusmn; 0.74 kg at 24 weeks, P < 0.01) than the placebo group.Conclusion: This nutraceutical combination results in significant fat loss in the absence of caloric restriction and markedly enhances weight and fat loss by 50%&ndash;80% over a 24-week period.Keywords: leucine, vitamin B6, pyridoxine, fat loss, weight loss, caloric restriction, adiposity, body composition
format article
author Zemel MB
Bruckbauer A
author_facet Zemel MB
Bruckbauer A
author_sort Zemel MB
title Effects of a leucine and pyridoxine-containing nutraceutical on body weight and composition in obese subjects
title_short Effects of a leucine and pyridoxine-containing nutraceutical on body weight and composition in obese subjects
title_full Effects of a leucine and pyridoxine-containing nutraceutical on body weight and composition in obese subjects
title_fullStr Effects of a leucine and pyridoxine-containing nutraceutical on body weight and composition in obese subjects
title_full_unstemmed Effects of a leucine and pyridoxine-containing nutraceutical on body weight and composition in obese subjects
title_sort effects of a leucine and pyridoxine-containing nutraceutical on body weight and composition in obese subjects
publisher Dove Medical Press
publishDate 2013
url https://doaj.org/article/4801ab0558e749e9bbe0dbd8cf629f51
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