Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors

Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors

The pathogenic human coronaviruses SARS- and MERS-CoV can cause severe respiratory disease. Here the authors present the 3.1Å cryo-EM structure of the SARS-CoV RNA polymerase nsp12 bound to its essential co-factors nsp7 and nsp8, which is of interest for antiviral drug development.

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Autores principales: Robert N. Kirchdoerfer, Andrew B. Ward
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/4802a022149745f89744160ad423f7d1
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spelling oai:doaj.org-article:4802a022149745f89744160ad423f7d12021-12-02T15:35:39ZStructure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors10.1038/s41467-019-10280-32041-1723https://doaj.org/article/4802a022149745f89744160ad423f7d12019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10280-3https://doaj.org/toc/2041-1723The pathogenic human coronaviruses SARS- and MERS-CoV can cause severe respiratory disease. Here the authors present the 3.1Å cryo-EM structure of the SARS-CoV RNA polymerase nsp12 bound to its essential co-factors nsp7 and nsp8, which is of interest for antiviral drug development.Robert N. KirchdoerferAndrew B. WardNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Robert N. Kirchdoerfer
Andrew B. Ward
Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors
description The pathogenic human coronaviruses SARS- and MERS-CoV can cause severe respiratory disease. Here the authors present the 3.1Å cryo-EM structure of the SARS-CoV RNA polymerase nsp12 bound to its essential co-factors nsp7 and nsp8, which is of interest for antiviral drug development.
format article
author Robert N. Kirchdoerfer
Andrew B. Ward
author_facet Robert N. Kirchdoerfer
Andrew B. Ward
author_sort Robert N. Kirchdoerfer
title Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors
title_short Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors
title_full Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors
title_fullStr Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors
title_full_unstemmed Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors
title_sort structure of the sars-cov nsp12 polymerase bound to nsp7 and nsp8 co-factors
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/4802a022149745f89744160ad423f7d1
work_keys_str_mv AT robertnkirchdoerfer structureofthesarscovnsp12polymeraseboundtonsp7andnsp8cofactors
AT andrewbward structureofthesarscovnsp12polymeraseboundtonsp7andnsp8cofactors
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