Two Distinct Mechanisms Govern RpoS-Mediated Repression of Tick-Phase Genes during Mammalian Host Adaptation by <italic toggle="yes">Borrelia burgdorferi</italic>, the Lyme Disease Spirochete

Two Distinct Mechanisms Govern RpoS-Mediated Repression of Tick-Phase Genes during Mammalian Host Adaptation by <italic toggle="yes">Borrelia burgdorferi</italic>, the Lyme Disease Spirochete

ABSTRACT The alternative sigma factor RpoS plays a key role modulating gene expression in Borrelia burgdorferi, the Lyme disease spirochete, by transcribing mammalian host-phase genes and repressing σ70-dependent genes required within the arthropod vector. To identify cis regulatory elements involve...

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Autores principales: Arianna P. Grove, Dionysios Liveris, Radha Iyer, Mary Petzke, Joseph Rudman, Melissa J. Caimano, Justin D. Radolf, Ira Schwartz
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2017
Materias:
Borrelia burgdorferi
Lyme disease
RpoS
sigma factors
transcriptional repression
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/4802d2aa53bd4b2595fcae11847b2786
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