Innate immunity limits protective adaptive immune responses against pre-erythrocytic malaria parasites

Here, Minkah et al. show that, while immunization with replication-competent Plasmodium parasites can confer sterile protection against infection, it also induces a type I interferon response that adversely affects anti-malaria immunity by affecting numbers of protective hepatic CD8 T cells and CD8...

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Autores principales:	Nana K. Minkah, Brandon K. Wilder, Amina A. Sheikh, Thomas Martinson, Lisa Wegmair, Ashley M. Vaughan, Stefan H. I. Kappe
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4803ab594660449eb646c58a1da8b3d4
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spelling	oai:doaj.org-article:4803ab594660449eb646c58a1da8b3d42021-12-02T15:35:12ZInnate immunity limits protective adaptive immune responses against pre-erythrocytic malaria parasites10.1038/s41467-019-11819-02041-1723https://doaj.org/article/4803ab594660449eb646c58a1da8b3d42019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11819-0https://doaj.org/toc/2041-1723Here, Minkah et al. show that, while immunization with replication-competent Plasmodium parasites can confer sterile protection against infection, it also induces a type I interferon response that adversely affects anti-malaria immunity by affecting numbers of protective hepatic CD8 T cells and CD8 T cell function.Nana K. MinkahBrandon K. WilderAmina A. SheikhThomas MartinsonLisa WegmairAshley M. VaughanStefan H. I. KappeNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nana K. Minkah Brandon K. Wilder Amina A. Sheikh Thomas Martinson Lisa Wegmair Ashley M. Vaughan Stefan H. I. Kappe Innate immunity limits protective adaptive immune responses against pre-erythrocytic malaria parasites
description	Here, Minkah et al. show that, while immunization with replication-competent Plasmodium parasites can confer sterile protection against infection, it also induces a type I interferon response that adversely affects anti-malaria immunity by affecting numbers of protective hepatic CD8 T cells and CD8 T cell function.
format	article
author	Nana K. Minkah Brandon K. Wilder Amina A. Sheikh Thomas Martinson Lisa Wegmair Ashley M. Vaughan Stefan H. I. Kappe
author_facet	Nana K. Minkah Brandon K. Wilder Amina A. Sheikh Thomas Martinson Lisa Wegmair Ashley M. Vaughan Stefan H. I. Kappe
author_sort	Nana K. Minkah
title	Innate immunity limits protective adaptive immune responses against pre-erythrocytic malaria parasites
title_short	Innate immunity limits protective adaptive immune responses against pre-erythrocytic malaria parasites
title_full	Innate immunity limits protective adaptive immune responses against pre-erythrocytic malaria parasites
title_fullStr	Innate immunity limits protective adaptive immune responses against pre-erythrocytic malaria parasites
title_full_unstemmed	Innate immunity limits protective adaptive immune responses against pre-erythrocytic malaria parasites
title_sort	innate immunity limits protective adaptive immune responses against pre-erythrocytic malaria parasites
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/4803ab594660449eb646c58a1da8b3d4
work_keys_str_mv	AT nanakminkah innateimmunitylimitsprotectiveadaptiveimmuneresponsesagainstpreerythrocyticmalariaparasites AT brandonkwilder innateimmunitylimitsprotectiveadaptiveimmuneresponsesagainstpreerythrocyticmalariaparasites AT aminaasheikh innateimmunitylimitsprotectiveadaptiveimmuneresponsesagainstpreerythrocyticmalariaparasites AT thomasmartinson innateimmunitylimitsprotectiveadaptiveimmuneresponsesagainstpreerythrocyticmalariaparasites AT lisawegmair innateimmunitylimitsprotectiveadaptiveimmuneresponsesagainstpreerythrocyticmalariaparasites AT ashleymvaughan innateimmunitylimitsprotectiveadaptiveimmuneresponsesagainstpreerythrocyticmalariaparasites AT stefanhikappe innateimmunitylimitsprotectiveadaptiveimmuneresponsesagainstpreerythrocyticmalariaparasites
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Innate immunity limits protective adaptive immune responses against pre-erythrocytic malaria parasites

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