Immunoprofiling of 4-1BB Expression Predicts Outcome in Chronic Lymphocytic Leukemia (CLL)

Recent success of novel therapies has improved treatment of chronic lymphocytic leukemia (CLL) patients, but most of them still require several treatment regimes. To improve treatment choice, prognostic markers suitable for prediction of disease outcome are required. Several molecular/genetic marker...

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Autores principales:	Kübra Kaban, Sarah M. Greiner, Samuel Holzmayer, Claudia Tandler, Sophie Meyer, Clemens Hinterleitner, Helmut R. Salih, Melanie Märklin, Jonas S. Heitmann
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	CLL 4-1BB/4-1BBL GITR/GITRL survival Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/48045c6f277e48eea4ecfe0855fc7d48
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spelling	oai:doaj.org-article:48045c6f277e48eea4ecfe0855fc7d482021-11-25T17:21:07ZImmunoprofiling of 4-1BB Expression Predicts Outcome in Chronic Lymphocytic Leukemia (CLL)10.3390/diagnostics111120412075-4418https://doaj.org/article/48045c6f277e48eea4ecfe0855fc7d482021-11-01T00:00:00Zhttps://www.mdpi.com/2075-4418/11/11/2041https://doaj.org/toc/2075-4418Recent success of novel therapies has improved treatment of chronic lymphocytic leukemia (CLL) patients, but most of them still require several treatment regimes. To improve treatment choice, prognostic markers suitable for prediction of disease outcome are required. Several molecular/genetic markers have been established, but accessibility for the entirety of all patients is limited. We here evaluated the relevance of GITR/4-1BB as well as their ligands for the prognosis of CLL patients. Surface expression of GITR/GITRL and 4-1BB/4-1BBL was correlated with established prognostic markers. Next, we separated our patient population according to GITR/GITRL and 4-1BB/4-1BBL expression in groups with high/low expression levels and performed Kaplan-Meier analyses. Interestingly, no correlation was observed with the defined prognostic markers. Whereas no significant difference between high and low expression of GITR, GITRL and 4-1BBL was observed, high 4-1BB levels on leukemic cells were associated with significantly shorter survival. Thereby we identify 4-1BB as prognostic marker for CLL.Kübra KabanSarah M. GreinerSamuel HolzmayerClaudia TandlerSophie MeyerClemens HinterleitnerHelmut R. SalihMelanie MärklinJonas S. HeitmannMDPI AGarticleCLL4-1BB/4-1BBLGITR/GITRLsurvivalMedicine (General)R5-920ENDiagnostics, Vol 11, Iss 2041, p 2041 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	CLL 4-1BB/4-1BBL GITR/GITRL survival Medicine (General) R5-920
spellingShingle	CLL 4-1BB/4-1BBL GITR/GITRL survival Medicine (General) R5-920 Kübra Kaban Sarah M. Greiner Samuel Holzmayer Claudia Tandler Sophie Meyer Clemens Hinterleitner Helmut R. Salih Melanie Märklin Jonas S. Heitmann Immunoprofiling of 4-1BB Expression Predicts Outcome in Chronic Lymphocytic Leukemia (CLL)
description	Recent success of novel therapies has improved treatment of chronic lymphocytic leukemia (CLL) patients, but most of them still require several treatment regimes. To improve treatment choice, prognostic markers suitable for prediction of disease outcome are required. Several molecular/genetic markers have been established, but accessibility for the entirety of all patients is limited. We here evaluated the relevance of GITR/4-1BB as well as their ligands for the prognosis of CLL patients. Surface expression of GITR/GITRL and 4-1BB/4-1BBL was correlated with established prognostic markers. Next, we separated our patient population according to GITR/GITRL and 4-1BB/4-1BBL expression in groups with high/low expression levels and performed Kaplan-Meier analyses. Interestingly, no correlation was observed with the defined prognostic markers. Whereas no significant difference between high and low expression of GITR, GITRL and 4-1BBL was observed, high 4-1BB levels on leukemic cells were associated with significantly shorter survival. Thereby we identify 4-1BB as prognostic marker for CLL.
format	article
author	Kübra Kaban Sarah M. Greiner Samuel Holzmayer Claudia Tandler Sophie Meyer Clemens Hinterleitner Helmut R. Salih Melanie Märklin Jonas S. Heitmann
author_facet	Kübra Kaban Sarah M. Greiner Samuel Holzmayer Claudia Tandler Sophie Meyer Clemens Hinterleitner Helmut R. Salih Melanie Märklin Jonas S. Heitmann
author_sort	Kübra Kaban
title	Immunoprofiling of 4-1BB Expression Predicts Outcome in Chronic Lymphocytic Leukemia (CLL)
title_short	Immunoprofiling of 4-1BB Expression Predicts Outcome in Chronic Lymphocytic Leukemia (CLL)
title_full	Immunoprofiling of 4-1BB Expression Predicts Outcome in Chronic Lymphocytic Leukemia (CLL)
title_fullStr	Immunoprofiling of 4-1BB Expression Predicts Outcome in Chronic Lymphocytic Leukemia (CLL)
title_full_unstemmed	Immunoprofiling of 4-1BB Expression Predicts Outcome in Chronic Lymphocytic Leukemia (CLL)
title_sort	immunoprofiling of 4-1bb expression predicts outcome in chronic lymphocytic leukemia (cll)
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/48045c6f277e48eea4ecfe0855fc7d48
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Immunoprofiling of 4-1BB Expression Predicts Outcome in Chronic Lymphocytic Leukemia (CLL)

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