Tissue fibrosis and its correlation with malignancy in canine mammary tumors

Background: Fibrosis is present in several pathologies associated with mammary carcinogenesis. Objective: To evaluate and quantify the fibrosis present in malignant and benign mammary neoplasms in bitches. Methods: Eighty-three samples were divided according to histopathological diagnosis into benig...

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Autores principales:	Gabriela N. Toledo, Marcus A. R. Feliciano, Ricardo A. R. Uscategui, Geórgia M. Magalhães, Gabriela M. Madruga, Wilter R. R. Vicente
Formato:	article
Lenguaje:	EN
Publicado:	Universidad de Antioquia 2018
Materias:	biological biomarkers breast cancer dogs histological stain histopathology masson’s trichrome Animal culture SF1-1100
Acceso en línea:	https://doaj.org/article/48066fd9d591459d95fce08fd34554ae
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spelling	oai:doaj.org-article:48066fd9d591459d95fce08fd34554ae2021-12-01T19:35:10ZTissue fibrosis and its correlation with malignancy in canine mammary tumors2256-295810.17533/udea.rccp.v31n4a06https://doaj.org/article/48066fd9d591459d95fce08fd34554ae2018-12-01T00:00:00Zhttps://revistas.udea.edu.co/index.php/rccp/article/view/330536https://doaj.org/toc/2256-2958Background: Fibrosis is present in several pathologies associated with mammary carcinogenesis. Objective: To evaluate and quantify the fibrosis present in malignant and benign mammary neoplasms in bitches. Methods: Eighty-three samples were divided according to histopathological diagnosis into benign (n= 21) and malignant (n= 62) neoplasms. Haematoxylin-eosin and Masson’s trichrome were used to locate the connective tissue, and the extent of fibrosis was assessed with image software. Results: Benign neoplasms were classified into adenomas (cystic, complex, and tubular), benign mixed tumor, and ductal and lobular hyperplasia. Malignant neoplasms were classified as carcinomas (complex, mixed tumor, in situ tubular, tubulopapillary, and solid). Grade I was the most prevalent histopathological class, followed by grade II and III. Fibrosis was classified as severe, moderate, or discrete. No significant (p>0.05) difference was observed for the percentage of fibrosis between malignant and benign group neoplasms. However, difference (p=0.028) was found for fibrosis percentage between histopathological subtypes of tumors. The benign subtype of lobular hyperplasia presented differences between cystic adenoma and benign mixed tumor. The in situ malignant tubular carcinoma subtype presented differences between solid and tubulopapillary carcinoma. Conclusions: Fibrosis in canine mammary tumors can be estimated with Massons’s trichrome staining.Gabriela N. ToledoMarcus A. R. FelicianoRicardo A. R. UscateguiGeórgia M. MagalhãesGabriela M. MadrugaWilter R. R. VicenteUniversidad de Antioquiaarticlebiological biomarkersbreast cancerdogshistological stainhistopathologymasson’s trichromeAnimal cultureSF1-1100ENRevista Colombiana de Ciencias Pecuarias, Vol 31, Iss 4, Pp 295-303 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	biological biomarkers breast cancer dogs histological stain histopathology masson’s trichrome Animal culture SF1-1100
spellingShingle	biological biomarkers breast cancer dogs histological stain histopathology masson’s trichrome Animal culture SF1-1100 Gabriela N. Toledo Marcus A. R. Feliciano Ricardo A. R. Uscategui Geórgia M. Magalhães Gabriela M. Madruga Wilter R. R. Vicente Tissue fibrosis and its correlation with malignancy in canine mammary tumors
description	Background: Fibrosis is present in several pathologies associated with mammary carcinogenesis. Objective: To evaluate and quantify the fibrosis present in malignant and benign mammary neoplasms in bitches. Methods: Eighty-three samples were divided according to histopathological diagnosis into benign (n= 21) and malignant (n= 62) neoplasms. Haematoxylin-eosin and Masson’s trichrome were used to locate the connective tissue, and the extent of fibrosis was assessed with image software. Results: Benign neoplasms were classified into adenomas (cystic, complex, and tubular), benign mixed tumor, and ductal and lobular hyperplasia. Malignant neoplasms were classified as carcinomas (complex, mixed tumor, in situ tubular, tubulopapillary, and solid). Grade I was the most prevalent histopathological class, followed by grade II and III. Fibrosis was classified as severe, moderate, or discrete. No significant (p>0.05) difference was observed for the percentage of fibrosis between malignant and benign group neoplasms. However, difference (p=0.028) was found for fibrosis percentage between histopathological subtypes of tumors. The benign subtype of lobular hyperplasia presented differences between cystic adenoma and benign mixed tumor. The in situ malignant tubular carcinoma subtype presented differences between solid and tubulopapillary carcinoma. Conclusions: Fibrosis in canine mammary tumors can be estimated with Massons’s trichrome staining.
format	article
author	Gabriela N. Toledo Marcus A. R. Feliciano Ricardo A. R. Uscategui Geórgia M. Magalhães Gabriela M. Madruga Wilter R. R. Vicente
author_facet	Gabriela N. Toledo Marcus A. R. Feliciano Ricardo A. R. Uscategui Geórgia M. Magalhães Gabriela M. Madruga Wilter R. R. Vicente
author_sort	Gabriela N. Toledo
title	Tissue fibrosis and its correlation with malignancy in canine mammary tumors
title_short	Tissue fibrosis and its correlation with malignancy in canine mammary tumors
title_full	Tissue fibrosis and its correlation with malignancy in canine mammary tumors
title_fullStr	Tissue fibrosis and its correlation with malignancy in canine mammary tumors
title_full_unstemmed	Tissue fibrosis and its correlation with malignancy in canine mammary tumors
title_sort	tissue fibrosis and its correlation with malignancy in canine mammary tumors
publisher	Universidad de Antioquia
publishDate	2018
url	https://doaj.org/article/48066fd9d591459d95fce08fd34554ae
work_keys_str_mv	AT gabrielantoledo tissuefibrosisanditscorrelationwithmalignancyincaninemammarytumors AT marcusarfeliciano tissuefibrosisanditscorrelationwithmalignancyincaninemammarytumors AT ricardoaruscategui tissuefibrosisanditscorrelationwithmalignancyincaninemammarytumors AT georgiammagalhaes tissuefibrosisanditscorrelationwithmalignancyincaninemammarytumors AT gabrielammadruga tissuefibrosisanditscorrelationwithmalignancyincaninemammarytumors AT wilterrrvicente tissuefibrosisanditscorrelationwithmalignancyincaninemammarytumors
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Tissue fibrosis and its correlation with malignancy in canine mammary tumors

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