ATP-dependent membrane remodeling links EHD1 functions to endocytic recycling

The GTPase dynamin catalyzes membrane fission but activity of the dynamin-related ATPase EHD1 is unknown. Here, using in vitro reconstitution assays and molecular dynamics simulations, the authors report that EHD1 hydrolyzes ATP to remodel, causing fission of membrane tubes and that this is necessar...

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Bibliographic Details
Main Authors: Raunaq Deo, Manish S. Kushwah, Sukrut C. Kamerkar, Nagesh Y. Kadam, Srishti Dar, Kavita Babu, Anand Srivastava, Thomas J. Pucadyil
Format: article
Language:EN
Published: Nature Portfolio 2018
Subjects:
Q
Online Access:https://doaj.org/article/4807e2ac29d34fc1af6988f7e983fda3
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Summary:The GTPase dynamin catalyzes membrane fission but activity of the dynamin-related ATPase EHD1 is unknown. Here, using in vitro reconstitution assays and molecular dynamics simulations, the authors report that EHD1 hydrolyzes ATP to remodel, causing fission of membrane tubes and that this is necessary for endocytic recycling.