ATP-dependent membrane remodeling links EHD1 functions to endocytic recycling

The GTPase dynamin catalyzes membrane fission but activity of the dynamin-related ATPase EHD1 is unknown. Here, using in vitro reconstitution assays and molecular dynamics simulations, the authors report that EHD1 hydrolyzes ATP to remodel, causing fission of membrane tubes and that this is necessar...

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Autores principales:	Raunaq Deo, Manish S. Kushwah, Sukrut C. Kamerkar, Nagesh Y. Kadam, Srishti Dar, Kavita Babu, Anand Srivastava, Thomas J. Pucadyil
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4807e2ac29d34fc1af6988f7e983fda3
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spelling	oai:doaj.org-article:4807e2ac29d34fc1af6988f7e983fda32021-12-02T15:34:42ZATP-dependent membrane remodeling links EHD1 functions to endocytic recycling10.1038/s41467-018-07586-z2041-1723https://doaj.org/article/4807e2ac29d34fc1af6988f7e983fda32018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07586-zhttps://doaj.org/toc/2041-1723The GTPase dynamin catalyzes membrane fission but activity of the dynamin-related ATPase EHD1 is unknown. Here, using in vitro reconstitution assays and molecular dynamics simulations, the authors report that EHD1 hydrolyzes ATP to remodel, causing fission of membrane tubes and that this is necessary for endocytic recycling.Raunaq DeoManish S. KushwahSukrut C. KamerkarNagesh Y. KadamSrishti DarKavita BabuAnand SrivastavaThomas J. PucadyilNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Raunaq Deo Manish S. Kushwah Sukrut C. Kamerkar Nagesh Y. Kadam Srishti Dar Kavita Babu Anand Srivastava Thomas J. Pucadyil ATP-dependent membrane remodeling links EHD1 functions to endocytic recycling
description	The GTPase dynamin catalyzes membrane fission but activity of the dynamin-related ATPase EHD1 is unknown. Here, using in vitro reconstitution assays and molecular dynamics simulations, the authors report that EHD1 hydrolyzes ATP to remodel, causing fission of membrane tubes and that this is necessary for endocytic recycling.
format	article
author	Raunaq Deo Manish S. Kushwah Sukrut C. Kamerkar Nagesh Y. Kadam Srishti Dar Kavita Babu Anand Srivastava Thomas J. Pucadyil
author_facet	Raunaq Deo Manish S. Kushwah Sukrut C. Kamerkar Nagesh Y. Kadam Srishti Dar Kavita Babu Anand Srivastava Thomas J. Pucadyil
author_sort	Raunaq Deo
title	ATP-dependent membrane remodeling links EHD1 functions to endocytic recycling
title_short	ATP-dependent membrane remodeling links EHD1 functions to endocytic recycling
title_full	ATP-dependent membrane remodeling links EHD1 functions to endocytic recycling
title_fullStr	ATP-dependent membrane remodeling links EHD1 functions to endocytic recycling
title_full_unstemmed	ATP-dependent membrane remodeling links EHD1 functions to endocytic recycling
title_sort	atp-dependent membrane remodeling links ehd1 functions to endocytic recycling
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/4807e2ac29d34fc1af6988f7e983fda3
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ATP-dependent membrane remodeling links EHD1 functions to endocytic recycling

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