Multi-site, multi-platform comparison of MRI T1 measurement using the system phantom.
Recent innovations in quantitative magnetic resonance imaging (MRI) measurement methods have led to improvements in accuracy, repeatability, and acquisition speed, and have prompted renewed interest to reevaluate the medical value of quantitative T1. The purpose of this study was to determine the bi...
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2021
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oai:doaj.org-article:480832cd44ec45bbb6fb399e7d6eae542021-12-02T20:15:45ZMulti-site, multi-platform comparison of MRI T1 measurement using the system phantom.1932-620310.1371/journal.pone.0252966https://doaj.org/article/480832cd44ec45bbb6fb399e7d6eae542021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0252966https://doaj.org/toc/1932-6203Recent innovations in quantitative magnetic resonance imaging (MRI) measurement methods have led to improvements in accuracy, repeatability, and acquisition speed, and have prompted renewed interest to reevaluate the medical value of quantitative T1. The purpose of this study was to determine the bias and reproducibility of T1 measurements in a variety of MRI systems with an eye toward assessing the feasibility of applying diagnostic threshold T1 measurement across multiple clinical sites. We used the International Society of Magnetic Resonance in Medicine/National Institute of Standards and Technology (ISMRM/NIST) system phantom to assess variations of T1 measurements, using a slow, reference standard inversion recovery sequence and a rapid, commonly-available variable flip angle sequence, across MRI systems at 1.5 tesla (T) (two vendors, with number of MRI systems n = 9) and 3 T (three vendors, n = 18). We compared the T1 measurements from inversion recovery and variable flip angle scans to ISMRM/NIST phantom reference values using Analysis of Variance (ANOVA) to test for statistical differences between T1 measurements grouped according to MRI scanner manufacturers and/or static field strengths. The inversion recovery method had minor over- and under-estimations compared to the NMR-measured T1 values at both 1.5 T and 3 T. Variable flip angle measurements had substantially greater deviations from the NMR-measured T1 values than the inversion recovery measurements. At 3 T, the measured variable flip angle T1 for one vendor is significantly different than the other two vendors for most of the samples throughout the clinically relevant range of T1. There was no consistent pattern of discrepancy between vendors. We suggest establishing rigorous quality control procedures for validating quantitative MRI methods to promote confidence and stability in associated measurement techniques and to enable translation of diagnostic threshold from the research center to the entire clinical community.Kathryn E KeenanZydrunas GimbutasAndrew DienstfreyKarl F StupicMichael A BossStephen E RussekThomas L ChenevertP V PrasadJunyu GuoWilburn E ReddickKim M CecilAmita Shukla-DaveDavid Aramburu NunezAmaresh Shridhar KonarMichael Z LiuSachin R JambawalikarLawrence H SchwartzJie ZhengPeng HuEdward F JacksonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0252966 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Kathryn E Keenan Zydrunas Gimbutas Andrew Dienstfrey Karl F Stupic Michael A Boss Stephen E Russek Thomas L Chenevert P V Prasad Junyu Guo Wilburn E Reddick Kim M Cecil Amita Shukla-Dave David Aramburu Nunez Amaresh Shridhar Konar Michael Z Liu Sachin R Jambawalikar Lawrence H Schwartz Jie Zheng Peng Hu Edward F Jackson Multi-site, multi-platform comparison of MRI T1 measurement using the system phantom. |
| description |
Recent innovations in quantitative magnetic resonance imaging (MRI) measurement methods have led to improvements in accuracy, repeatability, and acquisition speed, and have prompted renewed interest to reevaluate the medical value of quantitative T1. The purpose of this study was to determine the bias and reproducibility of T1 measurements in a variety of MRI systems with an eye toward assessing the feasibility of applying diagnostic threshold T1 measurement across multiple clinical sites. We used the International Society of Magnetic Resonance in Medicine/National Institute of Standards and Technology (ISMRM/NIST) system phantom to assess variations of T1 measurements, using a slow, reference standard inversion recovery sequence and a rapid, commonly-available variable flip angle sequence, across MRI systems at 1.5 tesla (T) (two vendors, with number of MRI systems n = 9) and 3 T (three vendors, n = 18). We compared the T1 measurements from inversion recovery and variable flip angle scans to ISMRM/NIST phantom reference values using Analysis of Variance (ANOVA) to test for statistical differences between T1 measurements grouped according to MRI scanner manufacturers and/or static field strengths. The inversion recovery method had minor over- and under-estimations compared to the NMR-measured T1 values at both 1.5 T and 3 T. Variable flip angle measurements had substantially greater deviations from the NMR-measured T1 values than the inversion recovery measurements. At 3 T, the measured variable flip angle T1 for one vendor is significantly different than the other two vendors for most of the samples throughout the clinically relevant range of T1. There was no consistent pattern of discrepancy between vendors. We suggest establishing rigorous quality control procedures for validating quantitative MRI methods to promote confidence and stability in associated measurement techniques and to enable translation of diagnostic threshold from the research center to the entire clinical community. |
| format |
article |
| author |
Kathryn E Keenan Zydrunas Gimbutas Andrew Dienstfrey Karl F Stupic Michael A Boss Stephen E Russek Thomas L Chenevert P V Prasad Junyu Guo Wilburn E Reddick Kim M Cecil Amita Shukla-Dave David Aramburu Nunez Amaresh Shridhar Konar Michael Z Liu Sachin R Jambawalikar Lawrence H Schwartz Jie Zheng Peng Hu Edward F Jackson |
| author_facet |
Kathryn E Keenan Zydrunas Gimbutas Andrew Dienstfrey Karl F Stupic Michael A Boss Stephen E Russek Thomas L Chenevert P V Prasad Junyu Guo Wilburn E Reddick Kim M Cecil Amita Shukla-Dave David Aramburu Nunez Amaresh Shridhar Konar Michael Z Liu Sachin R Jambawalikar Lawrence H Schwartz Jie Zheng Peng Hu Edward F Jackson |
| author_sort |
Kathryn E Keenan |
| title |
Multi-site, multi-platform comparison of MRI T1 measurement using the system phantom. |
| title_short |
Multi-site, multi-platform comparison of MRI T1 measurement using the system phantom. |
| title_full |
Multi-site, multi-platform comparison of MRI T1 measurement using the system phantom. |
| title_fullStr |
Multi-site, multi-platform comparison of MRI T1 measurement using the system phantom. |
| title_full_unstemmed |
Multi-site, multi-platform comparison of MRI T1 measurement using the system phantom. |
| title_sort |
multi-site, multi-platform comparison of mri t1 measurement using the system phantom. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2021 |
| url |
https://doaj.org/article/480832cd44ec45bbb6fb399e7d6eae54 |
| work_keys_str_mv |
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