Usefulness of computed tomography-measured psoas muscle thickness per height for predicting mortality in patients undergoing hemodialysis

Abstract Computed tomography (CT)-measured psoas muscle thickness standardized for height (PMTH) has emerged as a promising predictor of mortality. The study aimed to investigate whether PMTH could accurately predict mortality in patients undergoing hemodialysis. We examined 207 patients (mean age:...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Takahiro Yajima, Maiko Arao, Kumiko Yajima, Hiroshi Takahashi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/480a7dd5cced4dc497f7f9087095cf45
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:480a7dd5cced4dc497f7f9087095cf45
record_format	dspace
spelling	oai:doaj.org-article:480a7dd5cced4dc497f7f9087095cf452021-12-02T18:14:08ZUsefulness of computed tomography-measured psoas muscle thickness per height for predicting mortality in patients undergoing hemodialysis10.1038/s41598-021-98613-52045-2322https://doaj.org/article/480a7dd5cced4dc497f7f9087095cf452021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98613-5https://doaj.org/toc/2045-2322Abstract Computed tomography (CT)-measured psoas muscle thickness standardized for height (PMTH) has emerged as a promising predictor of mortality. The study aimed to investigate whether PMTH could accurately predict mortality in patients undergoing hemodialysis. We examined 207 patients (mean age: 63.1 years; men: 66.2%) undergoing hemodialysis for more than 6 months in hospital affiliated clinic. PMTH was calculated at the L3 vertebra level using CT. Patients were divided according to the PMTH cut-off points: 8.44 mm/m in women and 8.85 mm/m in men; thereafter, they were combined into low and high PMTH groups. PMTH was independently correlated with the simplified creatinine index (β = 0.213, P = 0.021) and geriatric nutritional risk index (β = 0.295, P < 0.0001) in multivariate regression analysis. During a median follow-up of 3.7 (1.8–6.4) years, 76 patients died, including 41 from cardiovascular causes. In the multivariate Cox regression analysis, low PMTH (adjusted hazard ratio, 2.48; 95% confidence interval, 1.36–4.70) was independently associated with an increased risk of all-cause mortality. The addition of binary PMTH groups to the baseline risk model tended to improve net reclassification improvement (0.460, p = 0.060). In conclusion, PMTH may be an indicator of protein energy wasting and a useful tool for predicting mortality in patients undergoing hemodialysis.Takahiro YajimaMaiko AraoKumiko YajimaHiroshi TakahashiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Takahiro Yajima Maiko Arao Kumiko Yajima Hiroshi Takahashi Usefulness of computed tomography-measured psoas muscle thickness per height for predicting mortality in patients undergoing hemodialysis
description	Abstract Computed tomography (CT)-measured psoas muscle thickness standardized for height (PMTH) has emerged as a promising predictor of mortality. The study aimed to investigate whether PMTH could accurately predict mortality in patients undergoing hemodialysis. We examined 207 patients (mean age: 63.1 years; men: 66.2%) undergoing hemodialysis for more than 6 months in hospital affiliated clinic. PMTH was calculated at the L3 vertebra level using CT. Patients were divided according to the PMTH cut-off points: 8.44 mm/m in women and 8.85 mm/m in men; thereafter, they were combined into low and high PMTH groups. PMTH was independently correlated with the simplified creatinine index (β = 0.213, P = 0.021) and geriatric nutritional risk index (β = 0.295, P < 0.0001) in multivariate regression analysis. During a median follow-up of 3.7 (1.8–6.4) years, 76 patients died, including 41 from cardiovascular causes. In the multivariate Cox regression analysis, low PMTH (adjusted hazard ratio, 2.48; 95% confidence interval, 1.36–4.70) was independently associated with an increased risk of all-cause mortality. The addition of binary PMTH groups to the baseline risk model tended to improve net reclassification improvement (0.460, p = 0.060). In conclusion, PMTH may be an indicator of protein energy wasting and a useful tool for predicting mortality in patients undergoing hemodialysis.
format	article
author	Takahiro Yajima Maiko Arao Kumiko Yajima Hiroshi Takahashi
author_facet	Takahiro Yajima Maiko Arao Kumiko Yajima Hiroshi Takahashi
author_sort	Takahiro Yajima
title	Usefulness of computed tomography-measured psoas muscle thickness per height for predicting mortality in patients undergoing hemodialysis
title_short	Usefulness of computed tomography-measured psoas muscle thickness per height for predicting mortality in patients undergoing hemodialysis
title_full	Usefulness of computed tomography-measured psoas muscle thickness per height for predicting mortality in patients undergoing hemodialysis
title_fullStr	Usefulness of computed tomography-measured psoas muscle thickness per height for predicting mortality in patients undergoing hemodialysis
title_full_unstemmed	Usefulness of computed tomography-measured psoas muscle thickness per height for predicting mortality in patients undergoing hemodialysis
title_sort	usefulness of computed tomography-measured psoas muscle thickness per height for predicting mortality in patients undergoing hemodialysis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/480a7dd5cced4dc497f7f9087095cf45
work_keys_str_mv	AT takahiroyajima usefulnessofcomputedtomographymeasuredpsoasmusclethicknessperheightforpredictingmortalityinpatientsundergoinghemodialysis AT maikoarao usefulnessofcomputedtomographymeasuredpsoasmusclethicknessperheightforpredictingmortalityinpatientsundergoinghemodialysis AT kumikoyajima usefulnessofcomputedtomographymeasuredpsoasmusclethicknessperheightforpredictingmortalityinpatientsundergoinghemodialysis AT hiroshitakahashi usefulnessofcomputedtomographymeasuredpsoasmusclethicknessperheightforpredictingmortalityinpatientsundergoinghemodialysis
_version_	1718378449171644416

Usefulness of computed tomography-measured psoas muscle thickness per height for predicting mortality in patients undergoing hemodialysis

Ejemplares similares