Barcoding reveals complex clonal behavior in patient-derived xenografts of metastatic triple negative breast cancer

Triple negative breast cancers (TNBC) disseminate and metastasise, but the clonal relationship of metastases to primary tumours is poorly understood. Here, the authors use cellular barcoding of TNBC patient-derived xenografts and track the fate of barcoded clones in primary tumours and their metasta...

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Autores principales:	D. Merino, T. S. Weber, A. Serrano, F. Vaillant, K. Liu, B. Pal, L. Di Stefano, J. Schreuder, D. Lin, Y. Chen, M. L. Asselin-Labat, T. N. Schumacher, D. Cameron, G. K. Smyth, A. T. Papenfuss, G. J. Lindeman, J. E. Visvader, S. H. Naik
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/480b0186e3224c0aa6da16a161fde4d0
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spelling	oai:doaj.org-article:480b0186e3224c0aa6da16a161fde4d02021-12-02T17:01:45ZBarcoding reveals complex clonal behavior in patient-derived xenografts of metastatic triple negative breast cancer10.1038/s41467-019-08595-22041-1723https://doaj.org/article/480b0186e3224c0aa6da16a161fde4d02019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08595-2https://doaj.org/toc/2041-1723Triple negative breast cancers (TNBC) disseminate and metastasise, but the clonal relationship of metastases to primary tumours is poorly understood. Here, the authors use cellular barcoding of TNBC patient-derived xenografts and track the fate of barcoded clones in primary tumours and their metastases, including after resection or chemotherapy.D. MerinoT. S. WeberA. SerranoF. VaillantK. LiuB. PalL. Di StefanoJ. SchreuderD. LinY. ChenM. L. Asselin-LabatT. N. SchumacherD. CameronG. K. SmythA. T. PapenfussG. J. LindemanJ. E. VisvaderS. H. NaikNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q D. Merino T. S. Weber A. Serrano F. Vaillant K. Liu B. Pal L. Di Stefano J. Schreuder D. Lin Y. Chen M. L. Asselin-Labat T. N. Schumacher D. Cameron G. K. Smyth A. T. Papenfuss G. J. Lindeman J. E. Visvader S. H. Naik Barcoding reveals complex clonal behavior in patient-derived xenografts of metastatic triple negative breast cancer
description	Triple negative breast cancers (TNBC) disseminate and metastasise, but the clonal relationship of metastases to primary tumours is poorly understood. Here, the authors use cellular barcoding of TNBC patient-derived xenografts and track the fate of barcoded clones in primary tumours and their metastases, including after resection or chemotherapy.
format	article
author	D. Merino T. S. Weber A. Serrano F. Vaillant K. Liu B. Pal L. Di Stefano J. Schreuder D. Lin Y. Chen M. L. Asselin-Labat T. N. Schumacher D. Cameron G. K. Smyth A. T. Papenfuss G. J. Lindeman J. E. Visvader S. H. Naik
author_facet	D. Merino T. S. Weber A. Serrano F. Vaillant K. Liu B. Pal L. Di Stefano J. Schreuder D. Lin Y. Chen M. L. Asselin-Labat T. N. Schumacher D. Cameron G. K. Smyth A. T. Papenfuss G. J. Lindeman J. E. Visvader S. H. Naik
author_sort	D. Merino
title	Barcoding reveals complex clonal behavior in patient-derived xenografts of metastatic triple negative breast cancer
title_short	Barcoding reveals complex clonal behavior in patient-derived xenografts of metastatic triple negative breast cancer
title_full	Barcoding reveals complex clonal behavior in patient-derived xenografts of metastatic triple negative breast cancer
title_fullStr	Barcoding reveals complex clonal behavior in patient-derived xenografts of metastatic triple negative breast cancer
title_full_unstemmed	Barcoding reveals complex clonal behavior in patient-derived xenografts of metastatic triple negative breast cancer
title_sort	barcoding reveals complex clonal behavior in patient-derived xenografts of metastatic triple negative breast cancer
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/480b0186e3224c0aa6da16a161fde4d0
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Barcoding reveals complex clonal behavior in patient-derived xenografts of metastatic triple negative breast cancer

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