Oral prodrug of remdesivir parent GS-441524 is efficacious against SARS-CoV-2 in ferrets
Remdesivir is an approved antiviral treatment for COVID-19, but it needs to be administered intravenously. Here, Cox et al. show that GS-621763, a prodrug of remdesivir parent nucleoside GS-441524 has good oral bioavailability and inhibits SARS-CoV-2 and variants of concerns in ferrets.
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Nature Portfolio
2021
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oai:doaj.org-article:480b9bcf109e47b7bd2093b34d9f46832021-11-08T11:10:59ZOral prodrug of remdesivir parent GS-441524 is efficacious against SARS-CoV-2 in ferrets10.1038/s41467-021-26760-42041-1723https://doaj.org/article/480b9bcf109e47b7bd2093b34d9f46832021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26760-4https://doaj.org/toc/2041-1723Remdesivir is an approved antiviral treatment for COVID-19, but it needs to be administered intravenously. Here, Cox et al. show that GS-621763, a prodrug of remdesivir parent nucleoside GS-441524 has good oral bioavailability and inhibits SARS-CoV-2 and variants of concerns in ferrets.Robert M. CoxJosef D. WolfCarolin M. LieberJulien SourimantMichelle J. LinDarius BabusisVenice DuPontJulie ChanKim T. BarrettDiane LyeRao KallaKwon ChunRichard L. MackmanChengjin YeTomas CihlarLuis Martinez-SobridoAlexander L. GreningerJohn P. BilelloRichard K. PlemperNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021) |
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Science Q Robert M. Cox Josef D. Wolf Carolin M. Lieber Julien Sourimant Michelle J. Lin Darius Babusis Venice DuPont Julie Chan Kim T. Barrett Diane Lye Rao Kalla Kwon Chun Richard L. Mackman Chengjin Ye Tomas Cihlar Luis Martinez-Sobrido Alexander L. Greninger John P. Bilello Richard K. Plemper Oral prodrug of remdesivir parent GS-441524 is efficacious against SARS-CoV-2 in ferrets |
description |
Remdesivir is an approved antiviral treatment for COVID-19, but it needs to be administered intravenously. Here, Cox et al. show that GS-621763, a prodrug of remdesivir parent nucleoside GS-441524 has good oral bioavailability and inhibits SARS-CoV-2 and variants of concerns in ferrets. |
format |
article |
author |
Robert M. Cox Josef D. Wolf Carolin M. Lieber Julien Sourimant Michelle J. Lin Darius Babusis Venice DuPont Julie Chan Kim T. Barrett Diane Lye Rao Kalla Kwon Chun Richard L. Mackman Chengjin Ye Tomas Cihlar Luis Martinez-Sobrido Alexander L. Greninger John P. Bilello Richard K. Plemper |
author_facet |
Robert M. Cox Josef D. Wolf Carolin M. Lieber Julien Sourimant Michelle J. Lin Darius Babusis Venice DuPont Julie Chan Kim T. Barrett Diane Lye Rao Kalla Kwon Chun Richard L. Mackman Chengjin Ye Tomas Cihlar Luis Martinez-Sobrido Alexander L. Greninger John P. Bilello Richard K. Plemper |
author_sort |
Robert M. Cox |
title |
Oral prodrug of remdesivir parent GS-441524 is efficacious against SARS-CoV-2 in ferrets |
title_short |
Oral prodrug of remdesivir parent GS-441524 is efficacious against SARS-CoV-2 in ferrets |
title_full |
Oral prodrug of remdesivir parent GS-441524 is efficacious against SARS-CoV-2 in ferrets |
title_fullStr |
Oral prodrug of remdesivir parent GS-441524 is efficacious against SARS-CoV-2 in ferrets |
title_full_unstemmed |
Oral prodrug of remdesivir parent GS-441524 is efficacious against SARS-CoV-2 in ferrets |
title_sort |
oral prodrug of remdesivir parent gs-441524 is efficacious against sars-cov-2 in ferrets |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/480b9bcf109e47b7bd2093b34d9f4683 |
work_keys_str_mv |
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