Oral prodrug of remdesivir parent GS-441524 is efficacious against SARS-CoV-2 in ferrets

Remdesivir is an approved antiviral treatment for COVID-19, but it needs to be administered intravenously. Here, Cox et al. show that GS-621763, a prodrug of remdesivir parent nucleoside GS-441524 has good oral bioavailability and inhibits SARS-CoV-2 and variants of concerns in ferrets.

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Autores principales: Robert M. Cox, Josef D. Wolf, Carolin M. Lieber, Julien Sourimant, Michelle J. Lin, Darius Babusis, Venice DuPont, Julie Chan, Kim T. Barrett, Diane Lye, Rao Kalla, Kwon Chun, Richard L. Mackman, Chengjin Ye, Tomas Cihlar, Luis Martinez-Sobrido, Alexander L. Greninger, John P. Bilello, Richard K. Plemper
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Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/480b9bcf109e47b7bd2093b34d9f4683
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spelling oai:doaj.org-article:480b9bcf109e47b7bd2093b34d9f46832021-11-08T11:10:59ZOral prodrug of remdesivir parent GS-441524 is efficacious against SARS-CoV-2 in ferrets10.1038/s41467-021-26760-42041-1723https://doaj.org/article/480b9bcf109e47b7bd2093b34d9f46832021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26760-4https://doaj.org/toc/2041-1723Remdesivir is an approved antiviral treatment for COVID-19, but it needs to be administered intravenously. Here, Cox et al. show that GS-621763, a prodrug of remdesivir parent nucleoside GS-441524 has good oral bioavailability and inhibits SARS-CoV-2 and variants of concerns in ferrets.Robert M. CoxJosef D. WolfCarolin M. LieberJulien SourimantMichelle J. LinDarius BabusisVenice DuPontJulie ChanKim T. BarrettDiane LyeRao KallaKwon ChunRichard L. MackmanChengjin YeTomas CihlarLuis Martinez-SobridoAlexander L. GreningerJohn P. BilelloRichard K. PlemperNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Robert M. Cox
Josef D. Wolf
Carolin M. Lieber
Julien Sourimant
Michelle J. Lin
Darius Babusis
Venice DuPont
Julie Chan
Kim T. Barrett
Diane Lye
Rao Kalla
Kwon Chun
Richard L. Mackman
Chengjin Ye
Tomas Cihlar
Luis Martinez-Sobrido
Alexander L. Greninger
John P. Bilello
Richard K. Plemper
Oral prodrug of remdesivir parent GS-441524 is efficacious against SARS-CoV-2 in ferrets
description Remdesivir is an approved antiviral treatment for COVID-19, but it needs to be administered intravenously. Here, Cox et al. show that GS-621763, a prodrug of remdesivir parent nucleoside GS-441524 has good oral bioavailability and inhibits SARS-CoV-2 and variants of concerns in ferrets.
format article
author Robert M. Cox
Josef D. Wolf
Carolin M. Lieber
Julien Sourimant
Michelle J. Lin
Darius Babusis
Venice DuPont
Julie Chan
Kim T. Barrett
Diane Lye
Rao Kalla
Kwon Chun
Richard L. Mackman
Chengjin Ye
Tomas Cihlar
Luis Martinez-Sobrido
Alexander L. Greninger
John P. Bilello
Richard K. Plemper
author_facet Robert M. Cox
Josef D. Wolf
Carolin M. Lieber
Julien Sourimant
Michelle J. Lin
Darius Babusis
Venice DuPont
Julie Chan
Kim T. Barrett
Diane Lye
Rao Kalla
Kwon Chun
Richard L. Mackman
Chengjin Ye
Tomas Cihlar
Luis Martinez-Sobrido
Alexander L. Greninger
John P. Bilello
Richard K. Plemper
author_sort Robert M. Cox
title Oral prodrug of remdesivir parent GS-441524 is efficacious against SARS-CoV-2 in ferrets
title_short Oral prodrug of remdesivir parent GS-441524 is efficacious against SARS-CoV-2 in ferrets
title_full Oral prodrug of remdesivir parent GS-441524 is efficacious against SARS-CoV-2 in ferrets
title_fullStr Oral prodrug of remdesivir parent GS-441524 is efficacious against SARS-CoV-2 in ferrets
title_full_unstemmed Oral prodrug of remdesivir parent GS-441524 is efficacious against SARS-CoV-2 in ferrets
title_sort oral prodrug of remdesivir parent gs-441524 is efficacious against sars-cov-2 in ferrets
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/480b9bcf109e47b7bd2093b34d9f4683
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