Nanoplasmonic fiber tip probe detects significant reduction of intracellular Alzheimer’s disease-related oligomers by curcumin

Abstract Considerable evidence shows critical roles of intracellular pathogenic events of Alzheimer’s disease (AD). In particular, intracellular amyloid-β accumulation and oligomerization are early AD pathologic processes, which may lead to changes in inflammatory molecules and other AD-related path...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Feng Liang, Yu Wan, Diane Schaak, Joseph Ward, Xunuo Shen, Rudolph E. Tanzi, Can Zhang, Qimin Quan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/480d2e5f3fb44bce97e032c128dc206f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:480d2e5f3fb44bce97e032c128dc206f
record_format	dspace
spelling	oai:doaj.org-article:480d2e5f3fb44bce97e032c128dc206f2021-12-02T12:32:19ZNanoplasmonic fiber tip probe detects significant reduction of intracellular Alzheimer’s disease-related oligomers by curcumin10.1038/s41598-017-05619-z2045-2322https://doaj.org/article/480d2e5f3fb44bce97e032c128dc206f2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05619-zhttps://doaj.org/toc/2045-2322Abstract Considerable evidence shows critical roles of intracellular pathogenic events of Alzheimer’s disease (AD). In particular, intracellular amyloid-β accumulation and oligomerization are early AD pathologic processes, which may lead to changes in inflammatory molecules and other AD-related pathological components. Curcumin and its analogs have been identified as potential drug candidates for AD. However, the effects of curcumin on intracellular AD pathologic processes remain largely unknown. Here we utilized a recently developed nanoplasmonic fiber tip probe (nFTP) technology and investigated whether curcumin leads to intracellular AD pathologic changes. We showed that our nFTP technology could robustly detect intracellular AD-related protein changes caused by a well-known inflammation inducer and a familial AD mutation. Intriguingly, curcumin remarkably reduced the level of intracellular oligomers while modestly reduced the level of an inflammatory cytokine. Thus, our results provided evidence that curcumin’s mechanism of action in attenuating AD pathology is through a major role of decreasing oligomerization.Feng LiangYu WanDiane SchaakJoseph WardXunuo ShenRudolph E. TanziCan ZhangQimin QuanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Feng Liang Yu Wan Diane Schaak Joseph Ward Xunuo Shen Rudolph E. Tanzi Can Zhang Qimin Quan Nanoplasmonic fiber tip probe detects significant reduction of intracellular Alzheimer’s disease-related oligomers by curcumin
description	Abstract Considerable evidence shows critical roles of intracellular pathogenic events of Alzheimer’s disease (AD). In particular, intracellular amyloid-β accumulation and oligomerization are early AD pathologic processes, which may lead to changes in inflammatory molecules and other AD-related pathological components. Curcumin and its analogs have been identified as potential drug candidates for AD. However, the effects of curcumin on intracellular AD pathologic processes remain largely unknown. Here we utilized a recently developed nanoplasmonic fiber tip probe (nFTP) technology and investigated whether curcumin leads to intracellular AD pathologic changes. We showed that our nFTP technology could robustly detect intracellular AD-related protein changes caused by a well-known inflammation inducer and a familial AD mutation. Intriguingly, curcumin remarkably reduced the level of intracellular oligomers while modestly reduced the level of an inflammatory cytokine. Thus, our results provided evidence that curcumin’s mechanism of action in attenuating AD pathology is through a major role of decreasing oligomerization.
format	article
author	Feng Liang Yu Wan Diane Schaak Joseph Ward Xunuo Shen Rudolph E. Tanzi Can Zhang Qimin Quan
author_facet	Feng Liang Yu Wan Diane Schaak Joseph Ward Xunuo Shen Rudolph E. Tanzi Can Zhang Qimin Quan
author_sort	Feng Liang
title	Nanoplasmonic fiber tip probe detects significant reduction of intracellular Alzheimer’s disease-related oligomers by curcumin
title_short	Nanoplasmonic fiber tip probe detects significant reduction of intracellular Alzheimer’s disease-related oligomers by curcumin
title_full	Nanoplasmonic fiber tip probe detects significant reduction of intracellular Alzheimer’s disease-related oligomers by curcumin
title_fullStr	Nanoplasmonic fiber tip probe detects significant reduction of intracellular Alzheimer’s disease-related oligomers by curcumin
title_full_unstemmed	Nanoplasmonic fiber tip probe detects significant reduction of intracellular Alzheimer’s disease-related oligomers by curcumin
title_sort	nanoplasmonic fiber tip probe detects significant reduction of intracellular alzheimer’s disease-related oligomers by curcumin
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/480d2e5f3fb44bce97e032c128dc206f
work_keys_str_mv	AT fengliang nanoplasmonicfibertipprobedetectssignificantreductionofintracellularalzheimersdiseaserelatedoligomersbycurcumin AT yuwan nanoplasmonicfibertipprobedetectssignificantreductionofintracellularalzheimersdiseaserelatedoligomersbycurcumin AT dianeschaak nanoplasmonicfibertipprobedetectssignificantreductionofintracellularalzheimersdiseaserelatedoligomersbycurcumin AT josephward nanoplasmonicfibertipprobedetectssignificantreductionofintracellularalzheimersdiseaserelatedoligomersbycurcumin AT xunuoshen nanoplasmonicfibertipprobedetectssignificantreductionofintracellularalzheimersdiseaserelatedoligomersbycurcumin AT rudolphetanzi nanoplasmonicfibertipprobedetectssignificantreductionofintracellularalzheimersdiseaserelatedoligomersbycurcumin AT canzhang nanoplasmonicfibertipprobedetectssignificantreductionofintracellularalzheimersdiseaserelatedoligomersbycurcumin AT qiminquan nanoplasmonicfibertipprobedetectssignificantreductionofintracellularalzheimersdiseaserelatedoligomersbycurcumin
_version_	1718394091573608448

Nanoplasmonic fiber tip probe detects significant reduction of intracellular Alzheimer’s disease-related oligomers by curcumin

Ejemplares similares