Serum Neutrophil Gelatinase-Associated Lipocalin (NGAL) Could Provide Better Accuracy Than Creatinine in Predicting Acute Kidney Injury Development in Critically Ill Patients

Acute kidney injury (AKI) is one of the most common complications in critically ill patients. In recent years, studies have focused on exploring new biomarkers for the early diagnosis and prognosis of AKI. The aim of this study was to investigate serum prognostic biomarkers (neutrophil gelatinase-as...

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Autores principales:	Edison Jahaj, Alice G. Vassiliou, Maria Pratikaki, Parisis Gallos, Zafeiria Mastora, Ioanna Dimopoulou, Stylianos E. Orfanos, Philippos Orfanos, Pagona Lagiou, Anastasia Kotanidou
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	acute kidney injury biomarkers ICU creatinine prognosis NGAL Medicine R
Acceso en línea:	https://doaj.org/article/480d9a31c26e4d4fac062461ff45c770
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spelling	oai:doaj.org-article:480d9a31c26e4d4fac062461ff45c7702021-11-25T18:02:14ZSerum Neutrophil Gelatinase-Associated Lipocalin (NGAL) Could Provide Better Accuracy Than Creatinine in Predicting Acute Kidney Injury Development in Critically Ill Patients10.3390/jcm102253792077-0383https://doaj.org/article/480d9a31c26e4d4fac062461ff45c7702021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5379https://doaj.org/toc/2077-0383Acute kidney injury (AKI) is one of the most common complications in critically ill patients. In recent years, studies have focused on exploring new biomarkers for the early diagnosis and prognosis of AKI. The aim of this study was to investigate serum prognostic biomarkers (neutrophil gelatinase-associated lipocalin, NGAL, and creatinine) of AKI in critically ill patients. The study included 266 critically ill, initially nonseptic, patients admitted to a multidisciplinary ICU. Serum levels of NGAL and creatinine were measured at ICU admission. ROC curves were generated to estimate the prognostic value of the biomarkers, while a logistic regression analysis was performed to assess their association with an increased AKI risk. Patients were divided in two groups based on the development (<i>n</i> = 98) or not (<i>n</i> = 168) of AKI during their ICU stay. Serum NGAL levels at ICU admission were significantly higher in those who subsequently developed AKI compared to those who did not (<i>p</i> < 0.0001). NGAL was shown to be more accurate in predicting AKI development than creatinine; furthermore, NGAL levels were associated with an increased risk of AKI development (1.005 (1.002–1.008), <i>p</i> < 0.0001). In the present study, we were able to demonstrate that increased serum NGAL levels at ICU admission might be predictive of AKI development during ICU hospitalization. Further studies are needed to support NGAL as a prognostic marker of acute kidney injury.Edison JahajAlice G. VassiliouMaria PratikakiParisis GallosZafeiria MastoraIoanna DimopoulouStylianos E. OrfanosPhilippos OrfanosPagona LagiouAnastasia KotanidouMDPI AGarticleacute kidney injurybiomarkersICUcreatinineprognosisNGALMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5379, p 5379 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	acute kidney injury biomarkers ICU creatinine prognosis NGAL Medicine R
spellingShingle	acute kidney injury biomarkers ICU creatinine prognosis NGAL Medicine R Edison Jahaj Alice G. Vassiliou Maria Pratikaki Parisis Gallos Zafeiria Mastora Ioanna Dimopoulou Stylianos E. Orfanos Philippos Orfanos Pagona Lagiou Anastasia Kotanidou Serum Neutrophil Gelatinase-Associated Lipocalin (NGAL) Could Provide Better Accuracy Than Creatinine in Predicting Acute Kidney Injury Development in Critically Ill Patients
description	Acute kidney injury (AKI) is one of the most common complications in critically ill patients. In recent years, studies have focused on exploring new biomarkers for the early diagnosis and prognosis of AKI. The aim of this study was to investigate serum prognostic biomarkers (neutrophil gelatinase-associated lipocalin, NGAL, and creatinine) of AKI in critically ill patients. The study included 266 critically ill, initially nonseptic, patients admitted to a multidisciplinary ICU. Serum levels of NGAL and creatinine were measured at ICU admission. ROC curves were generated to estimate the prognostic value of the biomarkers, while a logistic regression analysis was performed to assess their association with an increased AKI risk. Patients were divided in two groups based on the development (<i>n</i> = 98) or not (<i>n</i> = 168) of AKI during their ICU stay. Serum NGAL levels at ICU admission were significantly higher in those who subsequently developed AKI compared to those who did not (<i>p</i> < 0.0001). NGAL was shown to be more accurate in predicting AKI development than creatinine; furthermore, NGAL levels were associated with an increased risk of AKI development (1.005 (1.002–1.008), <i>p</i> < 0.0001). In the present study, we were able to demonstrate that increased serum NGAL levels at ICU admission might be predictive of AKI development during ICU hospitalization. Further studies are needed to support NGAL as a prognostic marker of acute kidney injury.
format	article
author	Edison Jahaj Alice G. Vassiliou Maria Pratikaki Parisis Gallos Zafeiria Mastora Ioanna Dimopoulou Stylianos E. Orfanos Philippos Orfanos Pagona Lagiou Anastasia Kotanidou
author_facet	Edison Jahaj Alice G. Vassiliou Maria Pratikaki Parisis Gallos Zafeiria Mastora Ioanna Dimopoulou Stylianos E. Orfanos Philippos Orfanos Pagona Lagiou Anastasia Kotanidou
author_sort	Edison Jahaj
title	Serum Neutrophil Gelatinase-Associated Lipocalin (NGAL) Could Provide Better Accuracy Than Creatinine in Predicting Acute Kidney Injury Development in Critically Ill Patients
title_short	Serum Neutrophil Gelatinase-Associated Lipocalin (NGAL) Could Provide Better Accuracy Than Creatinine in Predicting Acute Kidney Injury Development in Critically Ill Patients
title_full	Serum Neutrophil Gelatinase-Associated Lipocalin (NGAL) Could Provide Better Accuracy Than Creatinine in Predicting Acute Kidney Injury Development in Critically Ill Patients
title_fullStr	Serum Neutrophil Gelatinase-Associated Lipocalin (NGAL) Could Provide Better Accuracy Than Creatinine in Predicting Acute Kidney Injury Development in Critically Ill Patients
title_full_unstemmed	Serum Neutrophil Gelatinase-Associated Lipocalin (NGAL) Could Provide Better Accuracy Than Creatinine in Predicting Acute Kidney Injury Development in Critically Ill Patients
title_sort	serum neutrophil gelatinase-associated lipocalin (ngal) could provide better accuracy than creatinine in predicting acute kidney injury development in critically ill patients
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/480d9a31c26e4d4fac062461ff45c770
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Serum Neutrophil Gelatinase-Associated Lipocalin (NGAL) Could Provide Better Accuracy Than Creatinine in Predicting Acute Kidney Injury Development in Critically Ill Patients

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