Modulation of torque evoked by wide-pulse, high-frequency neuromuscular electrical stimulation and the potential implications for rehabilitation and training

Abstract The effectiveness of neuromuscular electrical stimulation (NMES) for rehabilitation is proportional to the evoked torque. The progressive increase in torque (extra torque) that may develop in response to low intensity wide-pulse high-frequency (WPHF) NMES holds great promise for rehabilitat...

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Autores principales:	Chris Donnelly, Jonathan Stegmüller, Anthony J. Blazevich, Fabienne Crettaz von Roten, Bengt Kayser, Daria Neyroud, Nicolas Place
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/481113a6d63546f08d2cfda7599e560d
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spelling	oai:doaj.org-article:481113a6d63546f08d2cfda7599e560d2021-12-02T13:18:08ZModulation of torque evoked by wide-pulse, high-frequency neuromuscular electrical stimulation and the potential implications for rehabilitation and training10.1038/s41598-021-85645-02045-2322https://doaj.org/article/481113a6d63546f08d2cfda7599e560d2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85645-0https://doaj.org/toc/2045-2322Abstract The effectiveness of neuromuscular electrical stimulation (NMES) for rehabilitation is proportional to the evoked torque. The progressive increase in torque (extra torque) that may develop in response to low intensity wide-pulse high-frequency (WPHF) NMES holds great promise for rehabilitation as it overcomes the main limitation of NMES, namely discomfort. WPHF NMES extra torque is thought to result from reflexively recruited motor units at the spinal level. However, whether WPHF NMES evoked force can be modulated is unknown. Therefore, we examined the effect of two interventions known to change the state of spinal circuitry in opposite ways on evoked torque and motor unit recruitment by WPHF NMES. The interventions were high-frequency transcutaneous electrical nerve stimulation (TENS) and anodal transcutaneous spinal direct current stimulation (tsDCS). We show that TENS performed before a bout of WPHF NMES results in lower evoked torque (median change in torque time-integral: − 56%) indicating that WPHF NMES-evoked torque might be modulated. In contrast, the anodal tsDCS protocol used had no effect on any measured parameter. Our results demonstrate that WPHF NMES extra torque can be modulated and although the TENS intervention blunted extra torque production, the finding that central contribution to WPHF NMES-evoked torques can be modulated opens new avenues for designing interventions to enhance WPHF NMES.Chris DonnellyJonathan StegmüllerAnthony J. BlazevichFabienne Crettaz von RotenBengt KayserDaria NeyroudNicolas PlaceNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chris Donnelly Jonathan Stegmüller Anthony J. Blazevich Fabienne Crettaz von Roten Bengt Kayser Daria Neyroud Nicolas Place Modulation of torque evoked by wide-pulse, high-frequency neuromuscular electrical stimulation and the potential implications for rehabilitation and training
description	Abstract The effectiveness of neuromuscular electrical stimulation (NMES) for rehabilitation is proportional to the evoked torque. The progressive increase in torque (extra torque) that may develop in response to low intensity wide-pulse high-frequency (WPHF) NMES holds great promise for rehabilitation as it overcomes the main limitation of NMES, namely discomfort. WPHF NMES extra torque is thought to result from reflexively recruited motor units at the spinal level. However, whether WPHF NMES evoked force can be modulated is unknown. Therefore, we examined the effect of two interventions known to change the state of spinal circuitry in opposite ways on evoked torque and motor unit recruitment by WPHF NMES. The interventions were high-frequency transcutaneous electrical nerve stimulation (TENS) and anodal transcutaneous spinal direct current stimulation (tsDCS). We show that TENS performed before a bout of WPHF NMES results in lower evoked torque (median change in torque time-integral: − 56%) indicating that WPHF NMES-evoked torque might be modulated. In contrast, the anodal tsDCS protocol used had no effect on any measured parameter. Our results demonstrate that WPHF NMES extra torque can be modulated and although the TENS intervention blunted extra torque production, the finding that central contribution to WPHF NMES-evoked torques can be modulated opens new avenues for designing interventions to enhance WPHF NMES.
format	article
author	Chris Donnelly Jonathan Stegmüller Anthony J. Blazevich Fabienne Crettaz von Roten Bengt Kayser Daria Neyroud Nicolas Place
author_facet	Chris Donnelly Jonathan Stegmüller Anthony J. Blazevich Fabienne Crettaz von Roten Bengt Kayser Daria Neyroud Nicolas Place
author_sort	Chris Donnelly
title	Modulation of torque evoked by wide-pulse, high-frequency neuromuscular electrical stimulation and the potential implications for rehabilitation and training
title_short	Modulation of torque evoked by wide-pulse, high-frequency neuromuscular electrical stimulation and the potential implications for rehabilitation and training
title_full	Modulation of torque evoked by wide-pulse, high-frequency neuromuscular electrical stimulation and the potential implications for rehabilitation and training
title_fullStr	Modulation of torque evoked by wide-pulse, high-frequency neuromuscular electrical stimulation and the potential implications for rehabilitation and training
title_full_unstemmed	Modulation of torque evoked by wide-pulse, high-frequency neuromuscular electrical stimulation and the potential implications for rehabilitation and training
title_sort	modulation of torque evoked by wide-pulse, high-frequency neuromuscular electrical stimulation and the potential implications for rehabilitation and training
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/481113a6d63546f08d2cfda7599e560d
work_keys_str_mv	AT chrisdonnelly modulationoftorqueevokedbywidepulsehighfrequencyneuromuscularelectricalstimulationandthepotentialimplicationsforrehabilitationandtraining AT jonathanstegmuller modulationoftorqueevokedbywidepulsehighfrequencyneuromuscularelectricalstimulationandthepotentialimplicationsforrehabilitationandtraining AT anthonyjblazevich modulationoftorqueevokedbywidepulsehighfrequencyneuromuscularelectricalstimulationandthepotentialimplicationsforrehabilitationandtraining AT fabiennecrettazvonroten modulationoftorqueevokedbywidepulsehighfrequencyneuromuscularelectricalstimulationandthepotentialimplicationsforrehabilitationandtraining AT bengtkayser modulationoftorqueevokedbywidepulsehighfrequencyneuromuscularelectricalstimulationandthepotentialimplicationsforrehabilitationandtraining AT darianeyroud modulationoftorqueevokedbywidepulsehighfrequencyneuromuscularelectricalstimulationandthepotentialimplicationsforrehabilitationandtraining AT nicolasplace modulationoftorqueevokedbywidepulsehighfrequencyneuromuscularelectricalstimulationandthepotentialimplicationsforrehabilitationandtraining
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Modulation of torque evoked by wide-pulse, high-frequency neuromuscular electrical stimulation and the potential implications for rehabilitation and training

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