Neural correlates of vocal initiation in the VTA/SNc of juvenile male zebra finches

Abstract Initiation and execution of complex learned vocalizations such as human speech and birdsong depend on multiple brain circuits. In songbirds, neurons in the motor cortices and basal ganglia circuitry exhibit preparatory activity before initiation of song, and that activity is thought to play...

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Autores principales:	Shin Yanagihara, Maki Ikebuchi, Chihiro Mori, Ryosuke O. Tachibana, Kazuo Okanoya
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4811938159304d4c85d1a4df511ca5d8
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spelling	oai:doaj.org-article:4811938159304d4c85d1a4df511ca5d82021-11-21T12:18:15ZNeural correlates of vocal initiation in the VTA/SNc of juvenile male zebra finches10.1038/s41598-021-01955-32045-2322https://doaj.org/article/4811938159304d4c85d1a4df511ca5d82021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01955-3https://doaj.org/toc/2045-2322Abstract Initiation and execution of complex learned vocalizations such as human speech and birdsong depend on multiple brain circuits. In songbirds, neurons in the motor cortices and basal ganglia circuitry exhibit preparatory activity before initiation of song, and that activity is thought to play an important role in successful song performance. However, it remains unknown where a start signal for song is represented in the brain and how such a signal would lead to appropriate vocal initiation. To test whether neurons in the midbrain ventral tegmental area (VTA) and substantia nigra pars compacta (SNc) show activity related to song initiation, we carried out extracellular recordings of VTA/SNc single units in singing juvenile male zebra finches. We found that a subset of VTA/SNc units exhibit phasic activity precisely time-locked to the onset of the song bout, and that the activity occurred specifically at the beginning of song. These findings suggest that phasic activity in the VTA/SNc represents a start signal that triggers song vocalization.Shin YanagiharaMaki IkebuchiChihiro MoriRyosuke O. TachibanaKazuo OkanoyaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shin Yanagihara Maki Ikebuchi Chihiro Mori Ryosuke O. Tachibana Kazuo Okanoya Neural correlates of vocal initiation in the VTA/SNc of juvenile male zebra finches
description	Abstract Initiation and execution of complex learned vocalizations such as human speech and birdsong depend on multiple brain circuits. In songbirds, neurons in the motor cortices and basal ganglia circuitry exhibit preparatory activity before initiation of song, and that activity is thought to play an important role in successful song performance. However, it remains unknown where a start signal for song is represented in the brain and how such a signal would lead to appropriate vocal initiation. To test whether neurons in the midbrain ventral tegmental area (VTA) and substantia nigra pars compacta (SNc) show activity related to song initiation, we carried out extracellular recordings of VTA/SNc single units in singing juvenile male zebra finches. We found that a subset of VTA/SNc units exhibit phasic activity precisely time-locked to the onset of the song bout, and that the activity occurred specifically at the beginning of song. These findings suggest that phasic activity in the VTA/SNc represents a start signal that triggers song vocalization.
format	article
author	Shin Yanagihara Maki Ikebuchi Chihiro Mori Ryosuke O. Tachibana Kazuo Okanoya
author_facet	Shin Yanagihara Maki Ikebuchi Chihiro Mori Ryosuke O. Tachibana Kazuo Okanoya
author_sort	Shin Yanagihara
title	Neural correlates of vocal initiation in the VTA/SNc of juvenile male zebra finches
title_short	Neural correlates of vocal initiation in the VTA/SNc of juvenile male zebra finches
title_full	Neural correlates of vocal initiation in the VTA/SNc of juvenile male zebra finches
title_fullStr	Neural correlates of vocal initiation in the VTA/SNc of juvenile male zebra finches
title_full_unstemmed	Neural correlates of vocal initiation in the VTA/SNc of juvenile male zebra finches
title_sort	neural correlates of vocal initiation in the vta/snc of juvenile male zebra finches
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4811938159304d4c85d1a4df511ca5d8
work_keys_str_mv	AT shinyanagihara neuralcorrelatesofvocalinitiationinthevtasncofjuvenilemalezebrafinches AT makiikebuchi neuralcorrelatesofvocalinitiationinthevtasncofjuvenilemalezebrafinches AT chihiromori neuralcorrelatesofvocalinitiationinthevtasncofjuvenilemalezebrafinches AT ryosukeotachibana neuralcorrelatesofvocalinitiationinthevtasncofjuvenilemalezebrafinches AT kazuookanoya neuralcorrelatesofvocalinitiationinthevtasncofjuvenilemalezebrafinches
_version_	1718419061293973504

Neural correlates of vocal initiation in the VTA/SNc of juvenile male zebra finches

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